- Фармакокинетика
- Показания к применению
- Способ применения
- Побочные действия
- Противопоказания
- Беременность
- Взаимодействие с другими лекарственными средствами
- Передозировка
- Условия хранения
- Форма выпуска
- Состав
- Дополнительно
Троксевазин Нео — комбинированный препарат для наружного применения. Действие обусловлено входящими в его состав ингредиентами:
Троксерутин — ангиопротекторное средство. Обладает Р-витаминной активностью: оказывает венотонизирующее, венопротекторное, противоотечное, противовоспалительное, противосвертывающее и антиоксидантное действие. Уменьшает проницаемость и ломкость капиляров, повышает их тонус. Увеличивает плотность сосудистой стенки. Способствует нормализации микроциркуляции и трофики тканей, уменьшает застойные явления.
Гепарин — антикоагулянт прямого действия, естественный противосвертывающий фактор организма. Препятствует тромбообразованию, активирует фибринолитические свойства крови, улучшает местный кровоток. Оказывает противовоспалительное действие, способствует регенерации соединительной ткани за счет угнетения активности гиалуронидазы.
Декспантенол — провитамин В5 — в коже превращается в пантотеновую кислоту, входящую в состав кофермента А, который играет важную роль в процессах ацетилирования и окисления. Улучшая обменные процессы, декспантенол способствует регенерации поврежденных тканей; улучшает всасывание гепарина.
Фармакокинетика
При местном применении активные вещества быстро абсорбируются кожей.
Гепарин накапливается в верхних слоях и активно связывается с протеинами кожи. При наружном применении незначительное количество гепарина проникает в системный кровоток, не оказывая системного действия, не вызывая каких-либо изменений параметров свертывания крови. Не проникает через плацентарный барьер.
Декспантенол проникает во все слои кожи и превращается в пантотеновую кислоту, связывается с белками плазмы (главным образом с бета-глобулином и альбумином). Пантотеновая кислота не подвергается в организме метаболизму и выводится в неизмененном виде.
Троксерутин через 30 минут обнаруживается в дерме, а через 2-5 часов в подкожной жировой клетчатке. Проникновение троксерутина в системный кровоток клинически незначимо.
Показания к применению
Показаниями к применению препарата Троксевазин Нео являются: варикозная болезнь; хроническая венозная недостаточность с такими симптомами как: отечность и боли в ногах; чувство тяжести, налитости, усталости ног; сосудистые звездочки и сеточки, судороги, парестезии; тромбофлебит; перифлебит; варикозный дерматит; боли и отеки травматического характера (при ушибах, растяжениях, травмах).
Способ применения
При необходимости гель можно наносить под бинты или эластичные чулки.
Успех лечения препаратом в большой степени зависит от его регулярного применения в течение длительного времени. Курс лечения составляет 2-3 недели. Необходимость более длительного лечения определяет лечащий врач.
Повторный курс лечения рекомендуется проводить 2-3 раза в год.
Рекомендуется сочетать с приемом капсул Троксевазин® для усиления воздействия.
Побочные действия
Аллергические реакции: кожная сыпь, зуд (в месте нанесения препарата).
Противопоказания
Противопоказаниями к применению препарата Троксевазин Нео являются: открытые инфицированные раны или раны с обильной экссудацией в месте нанесения; повышенная чувствительность к компонентам препарата; возраст младше 18 лет (опыт применения отсутствует).
Беременность
Троксевазин Нео разрешен к применению при беременности и в период лактации (грудного вскармливания).
Взаимодействие с другими лекарственными средствами
Взаимодействия препарата Троксевазин Нео с другими лекарственными средствами не выявлено.
Передозировка
Передозировка препарата Троксевазин Нео маловероятна в связи с малой системной абсорбцией активных компонентов геля.
Условия хранения
При температуре не выше 25 °С. Хранить в недоступном для детей месте!
Форма выпуска
Троксевазин Нео — гель для наружного применения.
По 40 г препарата в мембранную алюминиевую тубу или в мембранную ламинатную тубу.
Состав
1 г геля Троксевазин Нео содержит активные вещества: троксерутин 20 мг, декспантенол 50 мг, гепарин натрия 1,7 мг (соответствует 300 ME).
Вспомогательные вещества: карбомер 7 мг, пропиленгликоль 100 мг, метилпарагидроксибензоат 0,8 мг, пропилпарагидроксибензоат 0,2 мг, троламин 4,2 мг, вода очищенная до 1 г.
Описание актуально на 16.09.2015
- Латинское название: Troxevasin Neo
- Код АТХ: C05CA54
- Действующее вещество: Декспантенол (Dexpanthenol), Гепарин натрия (Heparin sodium), Троксерутин (Troxerutin)
- Производитель: ACTAVIS GROUP (Исландия)
Состав
В составе 1 грамма средства гель Троксевазин Нео содержится 20 мг троксерутина, 1,7 мг гепарина натрия, 50 мг декспантенола.
Дополнительные вещества: троламин, пропиленгликоль, карбомер, пропилпарагидроксибензоат, метилпарагидроксибензоат, вода.
Форма выпуска
Желтоватый прозрачный гель.
- 40 граммов геля в алюминиевой тубе — 1 туба в пачке из картона.
- 40 или 100 граммов геля в пластиковой тубе — 1 туба в пачке из картона.
Фармакологическое действие
Местное антитромботическое, венотонизирующее, ангиопротекторное и регенеративное действие.
Фармакодинамика и фармакокинетика
Фармакодинамика
Поликомпонентный препарат для местного применения.
Троксерутин является ангиопротекторным средством. Демонстрирует Р-витаминную активность: имеет венопротекторное, венотонизирующее, противовоспалительное, противоотечное, антиоксидантное и противосвертывающее действие. Снижает проницаемость и ломкость мелких сосудов, усиливает их тонус. Повышает плотность стенки сосудов. Способствует нормализации перфузии и трофики тканей, купирует застойные процессы.
Гепарин относится к антикоагулянтам прямого типа, естественный антисвертывающий фактор. Тормозит тромбообразование, стимулирует фибринолитические показатели крови, улучшает локальный кровоток. Имеет противовоспалительное действие, улучшает восстановление соединительной ткани ввиду ингибирования гиалуронидазы.
Декспантенол в клетках кожи трансформируется в пантотеновую кислоту, являющуюся составной частью кофермента А, который регулирует в процессы окисления и ацетилирования. Улучшая метаболизм, декспантенол способствует восстановлению тканей, которые повреждены; стимулирует абсорбцию гепарина.
Фармакокинетика
При локальном применении все вышеперечисленные действующие вещества активно абсорбируются кожей.
Троксерутин спустя уже полчаса обнаруживается в дерме, а спустя 3-5 часов — в подкожной жировой клетчатке. В системный кровоток Троксерутин почти не проникает.
Гепарин обычно накапливается в поверхностных слоях и активно реагирует с белками кожи. При местном применении только незначительный объем гепарина проникает в кровоток, не вызывая системного действия, не оказывая изменений показателей свертывания крови. Сквозь плацентарный барьер не проникает.
Декспантенол активно проникает в клетки кожи и трансформируется в пантотеновую кислоту, реагирует с белками плазмы (бета-глобулином и альбумином). В свою очередь пантотеновая кислота в организме не метаболизируется и выводится в первоначальном виде.
Показания к применению
- Тромбофлебит.
- Варикозная болезнь.
- Перифлебит.
- Венозная недостаточность хронического типа с сопутствующими болями в ногах, отечностью, чувством тяжести и усталости ног, судорогами, сосудистыми звездочками, парестезиями.
- Варикозный дерматит.
- Отеки и боли посттравматического характера (при растяжениях, ушибах, травмах).
Противопоказания
- Открытые зараженные раны или раны с сильной экссудацией в области нанесения.
- Гиперчувствительность к составляющим препарата.
- Возраст до 18 лет.
Побочные действия
Реакции аллергического типа: сыпь, зуд.
Инструкция по применению Троксевазин Нео (Способ и дозировка)
Троксевазин Нео применяют исключительно наружно. Тонкий слой препарата наносят на нужную область до двух раз в день (утром и вечером), распределяя его равномерно по коже втирающими движениями до окончательного впитывания. В случае необходимости гель разрешено наносить под эластичные чулки и бинты.
Эффект от лечения препаратом главным образом зависит от его регулярного использования в течение продолжительного времени. Курс терапии составляет обычно 2-3 недели. Нуждаемость в более продолжительном лечении определяет врач.
Дополнительные курсы терапии рекомендуется проводить до 3 раз в год.
Передозировка
Маловероятна из-за с незначительного системного всасывания активных составляющих геля.
Взаимодействие
Взаимодействия средства Троксевазин Нео с иными лекарственными препаратами не выявлено.
Условия продажи
Условия хранения
Хранить при комнатной температуре. Беречь от детей.
Срок годности
Особые указания
Необходимо избегать попадания лекарства на слизистые оболочки, в глаза и на открытые раны.
Троксевазин Нео нельзя использовать в офтальмологии, а также вводить интравагинального или ректального.
При приеме препарата не наблюдалось отрицательного влияния на способность вождения автотранспорта.
Аналоги
Венабос, Гепариновая мазь, Венолайф, Гепатромбин, Долобене, Тромблесс Плюс.
Детям
Препарат не предназначен для лечения детей.
При беременности и лактации
Препарат может использоваться в указанные периоды без ограничений.
Отзывы о Троксевазин Нео
Отзывы о геле свидетельствуют о высокой эффективности препарата при использовании по вышеперечисленным показаниям. Случаи возникновения побочных явлений крайне редки.
Цена Троксевазин Нео, где купить
Цена препарата (40 грамм) в России составляет приблизительно 280-335 рублей.
Комбинированное веностимулирующее лекарственное средство. Применение: варикоз, тромбофлебит, геморрой. Цена от 312 руб.
Аналоги: Троксерутин, Гепариновая мазь, Долобене, Тромбо АСС. Подробнее об аналогах, ценах на них, и являются ли они заменителями, вы сможете узнать в конце этой статьи.
Сегодня поговорим о геле Троксевазин Нео. Что за средство, как действует на организм? Какие имеет показания и противопоказания? Как и в каких дозах используется? Чем можно заменить?
Что за гель
Венозная недостаточность в последнее время значительно помолодела. На борьбу с проявлениями варикоза направлено большое количество лекарственных препаратов местного и общего действия.
Одним из таких средств является мазь Троксевазин и ее улучшенная копия Троксевазин Нео.
В отличие от Троксевазина, медикамент обладает пролонгированным действием, в его составе присутствует комплекс активных веществ.
Гель предназначен для устранения неприятных симптомов варикозного расширения вен легкой и средней степени тяжести.
Применяется исключительно наружно, не относится к стероидным производным, и не характеризуется завышенной стоимостью.
Действующее вещество и состав
Содержит комплекс действующих веществ, которые сочетаясь друг с другом, дают видимый и длительный эффект.
В 1 г крема содержится большее количество декспантенола, на втором месте – троксерутин, последнее место принадлежит гепарину натрия.
В составе присутствуют вспомогательные элементы, придающие мази желтоватый оттенок и специфический (ненавязчивый) запах. 1 г мази представлен:
- 300 МЕ гепарина;
- 20 мг троксерутина;
- 50 мг декспантенола;
- пропиленгликолем;
- троламином;
- карбомером;
- метилпарагидроксибензоатом;
- очищенной водой.
Фармакодинамика и фармакокинетика
Фармакологические свойства:
- ангиопротектор;
- противовоспалительное;
- веностимулирующее;
- антитромбозное;
- регенеративное.
Терапевтический эффект обуславливается присутствием большого количества действующих и вспомогательных компонентов.
Троксерутин оказывает выраженное ангиотпротекторное действия, а дополняясь гепарином – предотвращает скопление форменных элементов и нитей фибрина в просвете сосуда.
В месте нанесения оказывает антиоксидантный и противосвертывающий эффект.
Регенеративные свойства оказывает декспантенол, которые ускоряет процесс заживления микротрещин в венозных сосудах.
Выпятившиеся и воспаленные вены под действие геля скрываются, процессы тромбообразования затормаживаются, а при комплексной терапии – прекращают свое существование.
Воспаленная область при соприкосновении с лекарственным препаратом подвергается невыраженному биохимическому процессу:
- декспантенол снимает воспаление,
- гепарин разгоняет кровь,
- троксерутин улучшает состояние сосудистой стенки, устраняя ее спазм и восстанавливая кровоснабжение.
Фармакокинетика
Усвоение препарата происходит в несколько этапов. Активные компоненты в незначительном количестве проникают в кровь.
Печеночному метаболизму подвергается только декспантенол. Троксерутин накапливается в подкожно-жировой клетчатке, а гепарин – в поверхностных слоях эпидермиса.
Все компоненты вступают в реакцию с протеинами, период полувыведения составляет не более 18 часов.
За счет способности к накоплению в слоях дермы и стенки кровеносных сосудов эффект усиливается и продлевается.
Выводится декспантенол посредством мочевыделительной системы. Остальные компоненты полностью расщепляются.
Показания
- травмы в виде ушибов, растяжений, гематом (обычный Троксевазин не применяется в подобных случаях);
- отечность по причине усталости, перегруженности и в результате травм без повреждения сустава или кости;
- венозная недостаточность в стадии хронизации;
- варикоз первого и второго типа;
- образование сосудистых звездочек;
- тяжесть в ногах.
Целенаправленно мазь применяется для лечения тромбофлебита, перифлебита и варикозного дерматита.
Троксевазин нео применяется для устранения симптомов и лечения воспаленных геморроидальных узлов (геморрой), при пигментации и деформации венозных сосудов нижних (реже верхних) конечностей.
Противопоказания
- лицам, не достигшим восемнадцатилетнего возраста;
- женщинам «в положении» на ранних сроках;
- при наличии открытых инфицированных или воспаленных ран.
Ограничением к применению является повышенная чувствительность кожных покровов к любому веществу, входящему в состав медикамента.
Способ применения и дозировка
Мазь используется наружно. Пораженная область, больной участок или локализация места тяжести смазывается тонким слоем медикамента.
Для равномерного всасывания препарат растирается до полного впитывания.
Средство можно наносить под компрессионное белье или специальные чулки, утягивающие выступающие вены.
Применяется дважды в день после пробуждения, но после посещения душа, и перед отходом ко сну (после гигиенических процедур).
Для достижения выраженного эффекта, лечение длится 2-3 недели, повторяясь трижды в год.
При тяжелых нарушениях венозной системы терапия добавляется приемом пероральных средств с подобным эффектом: Троксевазин в капсулах.
Побочные эффекты
Возникновение побочных действий не исключено.
Проявляются симптомы в виде местного зуда и жжения.
Реже отмечаются папулезные высыпания, покраснение кожи и раздражение слизистой анального отверстия.
При наличии симптомов использование средства следует прекратить и обратиться за консультацией к терапевту или ангиохирургу.
В детском возрасте, при беременности и ГВ
В педиатрии не применяется, так как у препарата узкая специфичность, и детский возраст относится к противопоказаниям к использованию препарата.
Во время ожидания малыша мазь не рекомендуют использовать на ранних сроках гестации.
2 и 3 триместры беременности, а также лактационный период не являются основаниями к прекращению ангиопротекторной терапии.
Средство можно наносить как на кожные покровы, так и на слизистую ануса для смягчения геморроя.
Особые указания
Не следует допускать попадания геля на открытые раневые поверхности (за исключением трофических язв, возникших на фоне тромбофлебита).
При нанесении лекарственного средства не касаться слизистых оболочек рта и глаз.
В лечении геморроя допускается поверхностное нанесение крема в малых количествах. Вводить ректально Троксевазин Нео категорически запрещено.
При получении травм и ушибов малолетними детьми не допускается терапия ЛС.
При возникновении дискомфортных или болевых ощущений применение препарата прекратить, и обратиться за квалифицированной помощью.
Передозировка
По причине низкой системной абсорбции развитие признаков или симптомов передозировки исключено.
Возникновение местных изменений в виде дискомфорта или жжения связано с развитием побочных действий.
Аналоги
Аналоги подбираются с учетом показаний к применению. Основной заменитель – Троксевазин крем и капсулы для приема внутрь.
Троксерутин и гепариновая мазь – дешевые аналоги (средняя стоимость не более 60 рублей за 40 г крема).
Препараты идентичны по составу, фармакологическому принципу действия и показаниями к применению.
Похожим эффектом обладают мази нестероидного происхождения: Венолайф, Долобене, Тромбо АСС, Венорутон.
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