Троксерутин: инструкция по применению и отзывы
Латинское название: Troxerutin
Код ATX: C05CA04
Действующее вещество: Троксерутин (Troxerutin)
Производитель: ОАО “Биохимик”, Российская Федерация Sopharma AD, Адифарм ЭАТ, Болгария ЧАО ФФ “Дарница”, ПАО “Химзавод “Красная звезда”, Украина
Актуализация описания и фото: 19.10.2018
Цены в аптеках: от 30 руб.
Троксерутин – венопротекторный и венотонизирующий препарат.
Форма выпуска и состав
Лекарственные формы выпуска:
- капсулы: желатиновые твердые, размер №0, желтого цвета; содержимое капсул – порошок с гранулами или частицами различных размеров, спрессованных в цилиндры, распадающиеся при нажатии, от желтого до желто-зеленого, зеленовато-желтого или желто-коричневого цвета (по 10, 15, 20 шт. в контурных ячейковых упаковках из поливинилхлоридной пленки и алюминиевой фольги или по 30, 50, 60, 90, 100 шт. в полимерных банках; в пачке из картона: 1 банка; 3, 5, 6 контурных ячейковых упаковок по 10 шт.; 2, 4, 6 контурных ячейковых упаковок по 15 шт.; 3, 5 контурных ячейковых упаковок по 20 шт.);
- гель для наружного применения 2%: прозрачный, однородный, от желтого до желто-зеленого или светло-коричневого цвета (по 20, 25, 30, 40, 50, 60, 70, 80, 90 или 100 г в банках из оранжевого стекла, в полимерных банках или в алюминиевых тубах; 1 банка/туба в пачке из картона).
Состав 1 капсулы:
- активное вещество: троксерутин – 300 мг;
- вспомогательные вещества: микрокристаллическая целлюлоза – 44,1 мг, тальк – 9,25 мг, карбоксиметилкрахмал натрия [гликолят крахмал натрия (тип А), примоджель] – 9,25 мг, повидон (пласдон К90, коллидон 90F) – 3,7 мг;
- оболочка капсулы: оксид железа желтый краситель, диоксид титана, желатин.
Состав 100 мг геля:
- активное вещество: троксерутин – 2 мг;
- вспомогательный вещества: гидроксид натрия 30% – 0,7 мг; карбомер 940 – 0,6 мг; хлорид бензалкония – 0,0575 мг; эдетат динатрия – 0,05 мг; очищенная вода – до 100 мг.
Фармакологические свойства
Фармакодинамика
Биофлавоноид полусинтетический (производное рутина) класса бензопиранов, имеет Р-витаминную активность, осуществляет ангиопротекторное, венотонизирующее, противоотечное и противовоспалительное действие, понижает ломкость и проницаемость капилляров.
Фармакодинамические функции биофлавоноида троксерутина связаны с его участием в ингибировании и окислительно-восстановительных процессах гиалуронидазы. Удерживая гиалуронидазу, троксерутин нормализует гиалуроновую кислоту клеточных оболочек и снижает их проницаемость. Обладает антиоксидантной активностью, в результате чего не допускает окисления аскорбиновой кислоты, липидов и адреналина. Снижает ломкость и проницаемость капилляров, препятствует повреждению базальной мембраны эндотелиальных клеток при воздействии на нее различных элементов. Троксерутин повышает плотность стенки сосудов, снижает диапедез клеток крови и экссудацию жидкой части плазмы. Понижает экссудативное воспаление в сосудистой стенке, снижая адгезию тромбоцитов к ее поверхности. Замедляет агрегацию и повышает показатель деформации эритроцитов.
Применение троксерутина возможно не только на начальных, но и на поздних стадиях терапии хронической венозной недостаточности. Допускается использование препарата как в виде монотерапии одним из компонентов, так и в комплексной терапии. Троксерутин снижает отечность и ощущение тяжести в ногах, уменьшает интенсивность судорог и боли, улучшает трофику тканей.
Троксерутин послабляет симптомы, связанные с геморроем (экссудация, боль, кровотечение, зуд).
Троксерутин содействует замедлению прогрессирования диабетической ретинопатии, в результате воздействия на резистентность и проницаемость стенок капилляров.
Устранению развития микротромбоза сосудов сетчатки способствует влияние троксерутина на реологические свойства крови.
Фармакокинетика
- капсулы: всасывание из ЖКТ быстрое, максимальная концентрация троксерутина в плазме крови достигается в среднем за 1,5 часа после приема внутрь. Абсорбция – примерно 10–15%, с увеличением дозы препарата повышается биодоступность. Период полувыведения (Т1/2) – примерно 4–8 часов, терапевтическая концентрация вещества сохраняется в течение 8 часов в плазме крови. Второй максимум концентрации троксерутина в плазме крови, вызванный энтерогепатической рециркуляцией наблюдается через 30 часов после приема препарата. Троксерутин частично метаболизируется в печени с образованием глюкуронида и тригидроэтилкверцитина, в основном выводится через кишечник (до 65–70%), в неизмененном виде почками экскретируется меньшая часть лекарственного средства (до 25%);
- гель: действующее вещество при нанесении геля на области поражения быстро проникает через эпидермис, обнаруживается в дерме по прошествии 30 минут, а в подкожной жировой клетчатке через 2–5 часов.
Показания к применению
- поверхностный перифлебит и/или тромбофлебит;
- хроническая венозная недостаточность;
- гематомы мягких тканей и посттравматический отек.
Капсулы применяются в составе комбинированной терапии при перечисленных ниже состояниях/заболеваниях:
- геморрой (для послабления симптомов);
- трофические язвы и/или трофические нарушения при хронической венозной недостаточности;
- посттромботический синдром;
- варикозное расширение вен;
- после удаления и/или склеротерапии варикозно расширенных вен нижних конечностей – в виде вспомогательной терапии;
- диабетическая ретинопатия и ангиопатия.
Дополнительным показанием к применению Троксерутина в форме геля является варикозный дерматит.
Противопоказания
- Детский и подростковый возраст до 18 лет;
- повышенная чувствительность к компонентам препарата.
Дополнительно для капсул:
- I триместр беременности и период лактации;
- язвенная болезнь двенадцатиперстной кишки, желудка, хронический гастрит в стадии обострения.
Дополнительным противопоказанием для Троксерутина в форме геля является нарушение целостности кожных покровов.
При хронической почечной недостаточности применять препарат необходимо с особой осторожностью (при продолжительном применении).
Инструкция по применению Троксерутина: способ и дозировка
Капсулы
Капсулы Троксерутин принимают внутрь, во время приема пищи, их рекомендуется проглатывать целиком, запивая достаточным объемом воды.
Рекомендуемое дозирование: на начальной стадии – 3 раза в день по 1 шт., результат достигается примерно на протяжении 14 дней. Далее прием продолжают в той же дозе или снижают ее до средней терапевтической – 2 раза в день по 1 шт., либо приостанавливают (в этом случае полученный эффект сохраняется в течение не менее 4 недель).
При необходимости можно увеличивать дозу, но только после консультации с лечащим врачом. Курс лечения в среднем составляет 3–4 недели.
Поддерживающая терапия – по 1 шт. 1 раз в день, при диабетической ретинопатии – по 2 шт. 3 раза в день. Курс – 3–4 недели.
Гель Троксерутин применяется наружно.
Столбик геля высотой 4–5 см тонким слоем наносят на пораженные участки кожи и втирают легкими движениями 3–4 раза в день до полного впитывания. Суточная доза не должна превышать 20 см геля.
При необходимости возможно нанесение геля под эластичные чулки или бинты. Длительность лечения – 10 дней.
Побочные действия
Применение капсул может вызвать следующие побочные реакции со стороны систем и органов:
- иммунная система: реакции гиперчувствительности;
- нервная система: головная боль;
- сосудистая система: приливы крови к лицу;
- желудочно-кишечный тракт: боль в желудке, тошнота, рвота, диарея, метеоризм, эрозивно-язвенные поражения желудочно-кишечного тракта;
- кожа и подкожные ткани: кожный зуд, эритема, кожная сыпь.
При нанесении геля в редких случаях были замечены аллергические кожные реакции – экзема, крапивница, дерматит.
Передозировка
Возможны проявления следующих симптомов при системной передозировке троксерутина (прием капсул или случайное проглатывание геля в большом количестве): приливы крови к лицу, тошнота, возбуждение, головная боль.
При наличии данных нежелательных реакций следует промыть желудок и принять активированный уголь (на протяжении часа после приема).
Случаи передозировки геля при его наружном применении не описаны.
Особые указания
При терапии тромбоза глубоких вен или поверхностного тромбофлебита применение капсул Троксерутин не исключает назначения препаратов противотромботического и противовоспалительного действия.
Для лечения отеков, вызванных сопутствующими болезнями почек, печени и сердца, применять капсулы неэффективно.
Не следует превышать рекомендованные дозы и максимальные сроки лечения при самостоятельном применении лекарственного средства.
Если во время применения препарата выраженность симптомов заболевания не снижается или симптоматика отягощается, необходимо незамедлительно обратиться к специалисту.
Гель следует наносить только на неповрежденную поверхность.
Требуется избегать попадания геля в глаза, на слизистые оболочки и открытые раны.
Гель применяют в комплексе с аскорбиновой кислотой для усиления ее эффекта при состояниях, характеризующихся повышенной проницаемостью сосудов (в том числе при гриппе, скарлатине, кори и аллергических реакциях).
При непреднамеренном проглатывании препарата допустимы тошнота, рвота, ощущение жжения в полости рта, слюнотечение. В подобном случае рекомендуется промывание желудка и полости рта, при необходимости – симптоматическое лечение.
При попадании геля в глаза, на слизистые оболочки и открытые раны отмечается местное раздражение – жжение, слезотечение, боль, гиперемия. В этом случае необходимо смыть средство большим объемом изотонического раствора натрия хлорида или дистиллированной воды до значительного уменьшения выраженности или полного исчезновения указанных реакций.
Влияние на способность к управлению автотранспортом и сложными механизмами
Препарат не оказывает влияния на способность управлять транспортными средствами и иными сложными механизмами.
Применение при беременности и лактации
На протяжении I триместра беременности применение Троксерутина противопоказано. Применение препарата во II и III триместрах определяется лечащим врачом и возможно лишь тогда, когда предполагаемая польза для матери превышает потенциальный риск для плода.
Информация о проникновении препарата в грудное молоко отсутствует. Его применение в период лактации не рекомендуется.
Применение в детском возрасте
Согласно инструкции, Троксерутин противопоказан лицам, не достигшим восемнадцатилетнего возраста в связи с недостаточность данных о эффективности и безопасности его применения.
При нарушениях функции почек
Продолжительное применение у пациентов с хронической почечной недостаточностью требует соблюдения особой осторожности.
Лекарственное взаимодействие
При единовременном приеме троксерутина внутрь (капсулы), он усиливает действие аскорбиновой кислоты на проницаемость и резистентность стенки сосудов.
На сегодня нет данных о лекарственном взаимодействии троксерутина в форме геля.
Аналоги
Аналогами Троксерутина являются: Троксевазин, Троксевенол, Троксерутин Ветпром, Троксерутин Врамед, Троксерутин Зентива, Троксерутин-МИК.
Сроки и условия хранения
Хранить в сухом, защищенном от света месте при температуре, не превышающей 25 °С. Беречь от детей.
Срок хранения: капсулы – 3 года; гель для наружного применения 2% – 2 года.
Условия отпуска из аптек
Отпускается без рецепта.
Отзывы о Троксерутине
Согласно отзывам, Троксерутин практически не вызывает побочных эффектов при системном применении (капсулы) и является хорошим недорогим препаратом быстрого действия для облегчения боли в ногах.
Гель удобен в нанесении и не обладает каким-либо специфическим запахом, но в качестве незначительных недостатков отмечают желтоватый оттенок кожи в местах нанесения и незначительную липкость средства.
Цена на Троксерутин в аптеках
Цена на Троксерутин 300 мг (50 капсул в упаковке) составляет примерно 330 рублей.
Цена тубы Троксерутин гель 2%, массой 40 г, составляет примерно 50 рублей.
Троксерутин 2% 25г гель для наружного применения
Биохимик (Россия) Препарат: Троксерутин
Троксерутин врамед 2% 40г гель для наружного применения
Софарма (Болгария) Препарат: Троксерутин
Троксерутин 2% 40г гель для наружного применения
Озон (Россия) Препарат: Троксерутин
Троксерутин 30 шт. капсулы
Озон (Россия) Препарат: Троксерутин
Троксерутин 50 шт. капсулы
Озон (Россия) Препарат: Троксерутин
Троксерутин 2% 40г гель для наружного применения
Зеленая дубрава (Россия) Препарат: Троксерутин
Троксерутин 300мг 50 шт. капсулы
Синтез ОАО (Россия) Препарат: Троксерутин
Троксерутин 2% 40г гель для наружного применения
Тульская ФФ (Россия) Препарат: Троксерутин
Троксерутин 300мг 50 шт. капсулы
Биохимик (Россия) Препарат: Троксерутин
Троксерутин капсулы 100 шт.
Синтез ОАО (Россия) Препарат: Троксерутин
Троксерутин-мик 200мг 50 шт. капсулы
Минскинтеркапс ПРУП (Беларусь) Препарат: Троксерутин-мик
Троксерутин врамед 50 шт. капсулы
Софарма (Болгария) Препарат: Троксерутин врамед
Троксерутин зентива 30 шт. капсулы
Троксерутин зентива 60 шт. капсулы
Троксерутин зентива 90 шт. капсулы
Аналоги по действующему веществу
Троксерутин врамед 50 шт. капсулы
Софарма (Болгария) Препарат: Троксерутин врамед
Троксерутин зентива 30 шт. капсулы
Троксевазин 300мг 50 шт. капсулы
Тева (Болгария) Препарат: Троксевазин
Троксевазин 100 шт. капсулы
Тева (Болгария) Препарат: Троксевазин
Троксерутин вертекс 2% 50г гель для наружного применения
Аналоги из категории Препараты от варикоза
Детралекс 500мг 30 шт. таблетки покрытые пленочной оболочкой
Лаборатория Сервье (Россия) Препарат: Детралекс
Индовазин 45г гель для наружного применения
Тева (Болгария) Препарат: Индовазин
Лиотон 1000 100г гель
Берлин Хеми (Италия) Препарат: Лиотон 1000
Троксевазин 2% 40г гель для наружного применения
Тева (Болгария) Препарат: Троксевазин
Гепарин 25г мазь для наружного применения
Алтайвитамины (Россия) Препарат: Гепарин
Аналоги из категории Лекарства
Детралекс 500мг 60 шт. таблетки покрытые пленочной оболочкой
Лаборатория Сервье (Россия) Препарат: Детралекс
Лиотон 1000 30г гель
Берлин Хеми (Италия) Препарат: Лиотон 1000
Гепарин 25г мазь для наружного применения
Нижфарм (Россия) Препарат: Гепарин
Гепатромбин 300ме+2,5мг+2,5мг/г 40г гель для наружного применения
Докси-хем 500мг 30 шт. капсулы
Инструкция по применению Троксерутин
Состав и форма выпуска
Гель для наружного применения 2% — 1 г.:
- Активное вещество: троксерутин — 20 мг.
40 г — тубы алюминиевые (1) — пачки картонные.
Венотонизирующее и венопротекторное средство.
Троксерутин хорошо всасывается с поверхности кожи при его нанесении в виде геля. Активное вещество проникает в кровеносные сосуды подкожной ткани. При местном применении не вызывает системного действия на органы, так как не наблюдается значительного проникновения троксерутина в общее кровообращение.
Флановоид (производное рутина), обладает Р-витаминной активностью; оказывает венотонизирующее, ангиопротекторное, противовоспалительное и противоотечное действие.
Его фармакодипамические свойства связаны с участием биофлавоноидов троксерутина в окислительно-восстановительных процессах и ингибировании гиалуронидазы. Ингибируя гиалуронидазу, троксерутин стабилизирует гиалуроновую кислоту клеточных оболочек и уменьшает проницаемость и ломкость капилляров, повышает их тонус. Обладает антиоксидантной активностью, в результате чего предотвращает окисление аскорбиновой кислоты, адреналина и липидов. Предотвращает повреждение базальной мембраны эндотелиальных клеток при воздействии на нее различных факторов. Троксерутин снижает экссудативное воспаление в сосудистой стенке, ограничивая прилипание тромбоцитов к ее поверхности. В результате лечения троксерутином исчезает чувство тяжести в ногах, уменьшается отечность тканей, улучшается трофика.
Показания к применению Троксерутин
- хроническая венозная недостаточность;
- варикозное расширение вен;
- поверхностный тромбофлебит, перифлебит и флеботромбоз;
- посттравматический отек мягких тканей, гематома;
- посттромботический синдром.
Противопоказания к применению Троксерутин
- детский возраст до 18 лет;
- гиперчувствительность к троксерутину или любому другому вспомогательному веществу геля.
Троксерутин Применение при беременности и детям
Нет данных о неблагоприятном влиянии на развитие при применении препарата в первые месяцы беременности, поэтому нет противопоказаний его назначения беременным женщинам.
Нет данных об экскреции препарата в грудное молоко, поэтому троксерутин в виде геля можно назначать женщинам в период грудного вскармливания.
Троксерутин Врамед гель не применятся у детей.
Троксерутин Побочные действия
При лечении троксерутином (гель) редко наблюдаются побочные эффекты. При длительном применении возможны покраснение кожи и зуд.
Нет данных о неблагоприятном взаимодействии троксерутина с другими лекарственными средствами.
Дозировка Троксерутин
Гель наносят 2 раза/сут утром и вечером, осторожно втирая его в пораженные участки кожи легкими массирующими движениями. При необходимости гель можно применять в виде компрессов и окклюзивных повязок.
Троксерутин Врамед гель не применятся у детей.
Нет данных о передозировке препарата при его местном применении.
Реакция геля (рН) соответствует таковой кожи, поэтому при наружном применении не вызывает ее раздражения и гиперчувствительности.
Гель не нарушает нормальные физиологические свойства кожи (прохождение через поры, кислотно-щелочное равновесие, проницаемость), так как он создан на водной основе.
Влияние на способность выполнения потенциально опасных видов деятельности, требующих особого внимания и быстроты реакций (управление автомобилем и др. транспортными средствами, работа с движущимися механизмами, работа диспетчера и оператора и т.п.)
Применение препарата не влияет на способность к управлению транспортными средствами и занятию потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Ангиопротектор и корректор микроциркуляции крови. Применение: флебит, венозная недостаточность, варикоз. Цена от 240 руб.
Аналоги: Венолан, Троксевазин, Флеботон.
Что за препарат
Троксерутин капсулы назначают при различных заболеваниях вен. Относиться к необходимым для жизни препаратам.
Данное лекарство относиться к флавонидам. Отличается противовоспалительным, противоотечным, антиоксидантным действием. Входит в список важных и жизненно необходимых лекарств. Назначают пациентам разного возраста.
Капсулы выпускают по 300 мг. Также существует гель для наружного применения.
Перед использованием следует исключить наличие гиперчувствительности и индивидуальной непереносимости компонентов.
Троксерутин капсулы в инструкции по применению содержит необходимую информацию.
Действующее вещество и состав
Главным действующим веществом является троксерутин. Капсулы выпускают по 300 мг. Также существует гель для наружного применения.
Троксерутин состав также имеет вспомогательные компоненты:
- моногидрат лактозы;
- диоксид кремния;
- стеарат магния;
- диоксид титана;
- желатин.
Фармакологические свойства
Препарат Троксерутин оказывает флеботонизирующее действие. Накопление лекарства происходит только в слоях венозных вен. В них возникает максимальная концентрация. В других тканях она не значительная.
Лекарство предотвращает нарушение целостности мембран, которые связанные с окислением. Оказывает выраженное антиоксидантное действие. Производит защиту сосудистого слоя от окисления. Снижает чрезмерную проницаемость капилляров.
Фармакодинамика и фармакокинетика
ЛС имеет свойство повышать рефлюкс артерий и вен. Благодаря этому действию снижается поступление крови к коже, в лежачем положении.
Нормализирует микроциркуляцию крови.
Основное действие препарата предназначено на снижение болевого синдрома и других нарушений, которыми сопровождается венозная недостаточность.
Показания к применению
Капсулы Троксерутин показания к применению:
Рекомендуют принимать при первых признаках варикоза. Оказывает эффективное действие после травм, вывихов, тонуса мышц и судорог. В виде капсул назначают для комплексного лечения язв и различных дерматитов, которые возникли на фоне варикозного расширения вен.
В качестве комплексного лечения применяют при диабетической ретинопатии. Благодаря широкому спектру действий, повышает эластичность сосудов, очищает ткани от токсинов.
Противопоказания
Капсулы Троксерутин подходят не каждому пациенту и имеют определенные противопоказания.
- Запрещено использовать при непереносимости лактозы, галактозы.
- Не назначают детям, возрастом до 15 лет.
- С осторожностью можно принимать пациентам, которые страдают от нарушения функции почек.
Способ применения и дозировка
Стандартная доза приема – 2-3 капсулы в сутки. Курс лечения в основном длится 2-3 недели, пока полностью не исчезнут симптомы заболевания. В качестве поддерживающей терапии Троксерутин принимают по 1 капсуле в день. Профилактика может длиться до 4-х месяцев.
Для усиления эффекта могут дополнительно назначить гель для наружного использования. Также врачи часто назначают комбинированное лечение с применением разных препаратов. Самостоятельно применять строго не рекомендуется. Это может негативно повлиять на состояние здоровья пациента.
В детском возрасте, при беременности и ГВ
Троксерутин при беременности можно принимать за исключением первого триместра. На более поздних сроках лечение возможно при острой необходимости.
Пациент должен находиться под присмотром врача.
Детям старше 15 лет препарат назначают с осторожностью, в крайних случаях.
Побочные эффекты
В большинстве случаев препарат переносится хорошо. Иногда могут возникать такие нежелательные реакции:
- аллергия;
- раздражение кожи, покраснение;
- сыпь на коже;
- дерматит;
- отечности.
Такие проявления в основном исчезают самостоятельно, после прекращения приема лекарства. Компоненты в составе повышают риск развития аллергии. Это касается также замедленной формы. При первых нежелательных проявлениях следует обратиться к врачу.
Особые указания
Троксерутин врамед при длительном использовании может стать причиной развития гиперчувствительности. Если пациент страдает от нарушения функции почек, ему не рекомендуется принимать лекарство длительное время.
При отсутствии результата необходимо прекратить приме препарата и обратиться к специалисту.
Передозировка
Случаи передозировки в медицинской практике встречались очень редко. Если пациент случайно выпил больше капсул, чем разрешается, необходимо принять стандартные мероприятия.
Для этого вызывают рвоту и принимают препараты для симптоматического лечения. При отсутствии облегчения следует обратиться за помощью врачей.
Лекарственное взаимодействие
Данное средство хорошо взаимодействует с препаратами разных групп. Если одновременно применять с аскорбиновой кислотой, то будет усиливаться проницаемость сосудов. Возможно комбинированное лечение с другими медикаментами.
Аналоги
Препарат имеет выраженное действие, поэтому редко нуждается в заменителях.
Принимают только по назначению врача, строго соблюдая дозировку.
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