Артериальной гипертензией называют патологическое состояние, характеризующееся регулярным повышением артериального давления, значение которого превышает цифры 140/90 мм рт. ст. Такой диагноз ставится пациенту при условии, если высокое АД наблюдается при трех его измерениях, которые были произведены в разное время и на фоне спокойной обстановки. При этом крайне важно, чтобы перед подобными манипуляциями человек не принимал никаких препаратов, способствующих повышению или, наоборот, понижению давления.
Общая информация о заболевании
У кого чаще всего диагностируют артериальную гипертензию? Согласно утверждениям специалистов такое заболевание наблюдается примерно у 30 % людей пожилого и среднего возраста, хотя развитие подобной патологии не исключено и у подростков. Следует также отметить, что средний показатель заболеваемости женщин и мужчин имеет практически равное соотношение.
Среди всех форм артериальной гипертензии на легкие и умеренные степени приходится около 80 %.
Осложнения, терапия болезни
Артериальная гипертензия – это довольно серьезная медико-социальная проблема. Отсутствие должного и своевременного лечения такой болезни может поспособствовать развитию серьезных и опасных осложнений. В их число входят инсульт и инфаркт миокарда, которые могут стать причиной утраты трудоспособности человека, а также смертельного исхода.
Нельзя не сказать и о том, что злокачественное или продолжительное течение артериальной гипертензии приводит к существенному поражению артериол некоторых органов (например, глаз, мозга, почек и сердца) и нарушению их кровоснабжения.
Можно ли вылечить артериальную гипертензию? Терапия такого заболевания должна быть в первую очередь направлена на нормализацию высокого АД. Однако на этом лечение не заканчивается. Совместно с приемом препаратов, понижающих давление, требуется обязательная коррекция всех имеющихся нарушений, которые развились во внутренних органах.
Специалисты утверждают, что рассматриваемое заболевание часто носит хронический характер. На полное выздоровление в подобных случаях надеяться бесполезно, но правильно подобранное лечение может предотвратить последующее развитие патологии, а также значительно снизить риск возникновения тяжелых осложнений, в том числе гипертонических кризов.
Какое лекарство чаще всего назначают при артериальной гипертензии? Наиболее популярным препаратом при таком заболевании является «Телмисартан». Инструкция по применению, отзывы об этом медикаменте, его состав, побочные действия, противопоказания и прочие сведения представлены далее.
Описание препарата, упаковка, состав и форма выпуска
В какой форме выпускают лекарственное средство «Телмисартан»? Отзывы пациентов сообщают, что в аптечных сетях такой препарат можно встретить в виде круглых и плоскоцилиндрических таблеток белого цвета или с желтоватым оттенком, с риской и фаской.
Активным действующим компонентом этого медикамента является телмисартан. Что касается вспомогательных веществ, то в качестве них в состав таблеток входят:
- меглюмин;
- лактозы моногидрат (или молочный сахар);
- натрия гидроксид;
- кроскармеллоза натрия;
- повидон К25;
- магния стеарат.
Согласно отзывам «Телмисартан» в таблетках продается в аптеках в контурных ячейках, которые помещены в пачки из картона.
Фармакология
Что представляет собой медикамент «Телмисартан» (40 мг)? Отзывы специалистов утверждают, что это антигипертензивное лекарство, которое является антагонистом рецепторов типа АТ1, то есть ангиотензина II. Рассматриваемый препарат имеет высокое сродство с упомянутым подтипом рецепторов. Он избирательно и на протяжении длительного времени связывается с ангиотензином II, после чего активное вещество вытесняет его из связи с АТ1 рецепторами.
Другие особенности
Какие еще свойства присущи препарату «Телмисартан»? Отзывы сообщают, что действующий компонент этого средства никаким образом не влияет на АПФ и ренин, а также не блокирует каналы, которые ответственны за проведение ионов.
Упомянутое лекарство снижает количество альдостерона в крови. Дозировка препарата, равная 80 мг, полностью устраняет повышенное артериальное давление, которое было вызвано ангиотензинном II.
Терапевтические эффект после приема таблетки длится примерно сутки, а затем постепенно уменьшается. Также следует отметить, что значимое действие медикамента ощущается не менее двух дней после начала лечения.
Согласно отзывам «Телмисартан» способен снижать и систолическое, и диастолическое давление. Однако препарат никаким образом не влияет на частоту пульса человека. Также в процессе лечения не было отмечено эффекта привыкания и значимого накопления активного вещества препарата в организме.
Фармакокинетические свойства лекарства
Каким фармакокинетическими особенностями характеризуется медикамент «Телмисартан»? Инструкция и отзывы специалистов сообщают, что при приеме препарата внутрь его действующее вещество довольно быстро абсорбируется из пищеварительного тракта. Его биологическая доступность составляет около 50 %.
При применении препарата одновременно с пищей уменьшение AUC варьируется в пределах 6-9 % (при дозе 40-160 мг соответственно).
Через три часа после приема медикамента концентрация его активного компонента в плазме крови постепенно выравнивается (независимо о того, было ли принято лекарство вместе с едой или же натощак).
Связь телмисартана с плазменными белками составляет около 99,5 %. Метаболизируется это вещество посредством конъюгирования с глюкуроновой кислотой. При этом образуются фармакологически неактивные метаболиты.
Период полувыведения рассматриваемого препарата составляет более 20 часов. Выводится его активное вещество в неизмененном виде через кишечник. Кумулятивное выведение посредством почечной системы составляет около 1 %.
Показания к назначению препарата
В каких случаях назначают такое лекарственное средство, как «Телмисартан»? Отзывы врачей сообщают, что рассматриваемый препарат активно применяется во время лечения артериальной гипертензии. Также оно может быть назначено для профилактики смертности людей от патологий сердечно-сосудистой системы, в том числе после инфаркта, инсульта, болезней периферических сосудов и при гипертрофии левого желудочка.
Запреты к назначению перорального средства
Когда не следует использовать таблетки «Телмисартан»? Отзывы специалистов, а также инструкция по применению этого препарата говорят о следующих противопоказаниях к назначению:
- обструктивные болезни желчевыводящих путей;
- первичный альдостеронизм;
- печеночная недостаточность тяжелой степени;
- тяжелые нарушения функции почек;
- непереносимость больным фруктозы;
- чрезмерная чувствительность пациента к основному веществу или другим компонентам лекарства;
- период беременности;
- несовершеннолетний возраст;
- период грудного вскармливания.
Инструкция по применению
Как следует использовать препарат «Телмисартан» (40 мг)? Отзывы врачей указывают на то, что принимать упомянутые таблетки необходимо внутрь (перорально), независимо от приема пищи.
При диагностировании артериальной гипертензии рассматриваемый медикамент обычно назначают в дозировке 40 мг один раз в день. Однако в некоторых случаях указанная доза может быть уменьшена в два раза (при условии, если лекарство оказалось эффективным в количестве 20 мг).
Если при приеме 40 мг препарата желаемого эффекта достичь так и не удалось, то дозу увеличивают максимум до 80 мг. В этом случае применение всей дозировки осуществляют за один раз.
При коррекции лечения следует учитывать, что максимальный терапевтический эффект достигается не сразу, а по прошествии 1-2 месяца (при условии регулярного приема таблеток).
Чтобы снизить артериальное давление, препарат «Телмисартан» (80 мг), отзывы о котором указаны далее, очень часто назначают совместно с тиазидными диуретиками.
Прием препарата при сердечно-сосудистых заболеваниях
Эффективность таблеток «Телмисартана», применяемых для профилактики смертности у пациентов с проблемами сердечно-сосудистой системы, наблюдается при дозе в 80 мг в день. Отмечается ли аналогичный результат при более низких дозировках в настоящее время неизвестно.
При заболеваниях печени и почек следует обязательно удостовериться, что указанное количество препарата не спровоцирует развитие побочных эффектов со стороны упомянутых органов. Поэтому в подобных случаях рекомендуется начинать лечение с дозы 20 мг в день. Также необходимо учитывать, что для большинства людей с нарушенной работой печени опасна дозировка выше 40 мг в сутки.
Побочные явления
Какие эффекты побочного характера способен вызвать медикамент «Телмисартан 80»? Отзывы специалистов сообщают, что негативные явления на фоне приема рассматриваемого средства наблюдаются крайне редко. Однако в некоторых случаях пациенты все же жалуются на следующие состояния:
- Брадикардия, анемия, одышка, рвота, высокое количество креатинина в крови, нарушения сна, диарея, боль в области спины.
- Депрессивные состояния, диспноэ, вертиго, судороги икр, обмороки, зуд кожи, резкое падение АД, болезненные ощущения в области живота, слабость.
- Диспепсия, высыпания, острая почечная недостаточность, гиперкалиемия, боль в грудной клетке, нарушенная работа почек, повышенное потоотделение.
- Мышечная боль, инфекционные болезни дыхательных и мочевыводящих путей (например, цистит, синусит или фарингит), тахикардия, сепсис, зрительные расстройства, тромбоцитопения, чувство сухости во рту.
- Снижение уровня гемоглобина, дискомфорт в желудке, чувство беспокойства, боли в суставах, падение АД при смене положения тела, нарушенная работа печени, эритема, повышение активности ферментов печени, экзематозная сыпь, повышение уровня мочевой кислоты в крови.
- Боль в сухожилиях, ангионевротический отек, тендинит, токсические высыпания, повышение уровня эозинофилов.
Важно знать!
C особой осторожностью препарат «Телмисартан» назначают при нарушенной работе печени, стенозе аорты, язвенной болезни желудка и 12-перстной кишки (в период обострения), ИБС, заболеваниях органов пищеварения, стенозе митрального клапана, сердечной недостаточности и гипертрофической обструктивной кардиомиопатии.
У людей с уменьшенным ОЦК, а также с гипонатриемией может развиться симптоматическая артериальная гипотензия (в том числе после приема первой таблетки препарата). В связи с этим перед проведением лечения требуется коррекция указанных состояний.
Категорически запрещается применять телмисартан у больных с первичным альдостеронизмом.
Использование препарата возможно в сочетании с тиазидными диуретиками, так как подобная комбинация способствует дополнительному снижению АД.
Препарат от повышенного АД «Телмисартан»: отзывы и аналоги
Аналогами рассматриваемого медикамента являются такие средства, как:
Перед применением указанных лекарств с целью устранения артериальной гипертензии следует иметь в виду, что они обладают своими фармакологическими особенностями, побочными эффектами и противопоказаниями.
Насколько эффективно действует препарат «Телмисартан»? Отзывы пациентов об этом лекарстве встречаются крайне редко. Из тех сообщений, что имеются на сегодняшний день, около 80 % носят положительный характер. Люди, страдающие от регулярного повышения давления, утверждают, что прием упомянутых таблеток позволяет быстро и достаточно мягко его нормализовать. Также пациентов радует тот факт, что данный медикамент крайне редко вызывает побочные явления.
Среди всего многообразия лекарств, с помощью которых можно скорректировать артериальное и внутричерепное давление, сложно отыскать препарат, который дает минимальные побочные реакции. Телмисартан Тева относится к таким средствам. С помощью этого медикамента можно не только нормализовать АД , но и сократить риск развития инсультов и инфарктов до минимума, своевременно подавив стеноз артерии.
Международное непатентованное название
Telmisartan. Торговые наименования:
- Прайтор;
- Телзап;
- Танидол и др.
С помощью Телмисартана Тева можно скорректировать артериальное и внутричерепное давление.
Формы выпуска и состав
Выпускается медикамент в форме таблеток, в которых содержится по 80 или 40 мг активного компонента — телмисартана. Дополнительные ингредиенты:
- магниевый стеарат;
- меглюмин;
- натриевый гидрохлортиазид;
- маннитол;
- повидон;
- гидроксипропилметилцеллюлоза.
Фармакологическое действие
Препарат — антагонист рецепторов ангиотензина ii. Он отличается хорошим лекарственным взаимодействием с Амлодипином, поэтому они нередко комбинируются друг с другом.
Примерно спустя 2,5-3 часа после употребления лекарства наблюдается уменьшение АД. Предельное уменьшение его действия наступает через 4 недели после курса лечения препаратов.
При уменьшении давления этот медикамент не оказывает никакого влияния на сердечный ритм и состояние почечных артерий. Фармацевтическому воздействию подвергается только диастолическое и систолическое АД. Это одна из особенностей действующего вещества.
При уменьшении давления этот медикамент не оказывает никакого влияния на сердечный ритм.
Фармакокинетика
При пероральном приеме медикамент оперативно всасывается из желудочно-кишечного тракта. Препарат обладает 50% биологической доступностью. Метаболизируется лекарство посредством взаимодействия с глюкуроновой кислотой. При этом выделяются неактивные метаболиты.
Показания к применению
Лекарство назначается больным гипертонией. Кроме того, им нередко пользуются профессиональные бодибилдеры из-за регулярного повышения артериального давления.
Курс лечения препаратом позволяет не только стабилизировать давление, но и улучшить самочувствие и стабилизировать работу альдостероновой системы. С применением этого лекарства осуществляется профилактика атеросклероза и инсульта, что связано с его положительным воздействием на функционирование и структуру ГМ (головного мозга).
Этими таблетками нередко пользуются люди, желающие избавиться от лишних килограммов, потому что его действующие вещества обладают метаболическим действием.
Препаратом нередко пользуются люди, желающие избавиться от лишних килограммов.
Противопоказания
Перед использованием медикамента, нужно внимательно изучить ограничения к его приему. Медикамент нежелательно принимать при беременности.
Состоявшимся мамам при его применении необходимо отказаться от грудного вскармливания ребенка.
У лекарства есть и иные противопоказания:
- индивидуальная непереносимость вспомогательных и активных веществ лекарства;
- тяжелое нарушение функции почек;
- тяжелое нарушение функции печени;
- обструкция желчного пузыря.
С осторожностью
Осторожно назначается пациентам с реноваскулярной формой гипертензии или кардиопатией. К относительным противопоказаниям также можно отнести стеноз аортального и митрального клапана, восстановление после трансплантации.
Как принимать Телмисартан
Препарат предназначен для приема внутрь. Дневная дозировка для взрослых — от 20 до 40 мг раз в день. Максимальная суточная доза — 80 мг. Медикамент используется независимо от приема пищи.
Прием препарата при сахарном диабете
У больных сахарным диабетом, которые пользуются этим медикаментом, увеличивается риск развития фатальной формы инфаркта миокарда. Поэтому такие пациенты нуждаются в предварительном диагностическом обследовании.
Побочные действия
При использовании медикаментозного средства могут возникать некоторые побочные проявления, в том числе и развитие синдрома отмены после использования.
Желудочно-кишечный тракт
- вздутие живота;
- понос или запор;
- тошнота и рвота;
- увеличение степени активности печеночных трансаминаз,
Понос — один из побочных эффектов со стороны ЖКТ.
Органы кроветворения
Уменьшение уровня гемоглобина в плазме крови. Редко — анемия.
Центральная нервная система
- головокружения;
- головные боли;
- нарушения сна;
- повышенная раздражительность;
- депрессивные состояния и пр.
Со стороны мочевыделительной системы
- инфекции;
- периферическая отечность;
- гиперкреатининемия и т.д.
Со стороны дыхательной системы
- фарингит;
- нарушение работы легких;
- хронический кашель.
Для побочных реакций со стороны дыхательной системы характерен хронический кашель.
Со стороны костно-мышечной системы
- артралгия;
- миалгия;
- болезненность и дискомфорт в области поясницы.
Со стороны сердечно-сосудистой системы
- болезненные ощущения в груди;
- аритмия и тахикардия;
- уменьшение артериального давления.
Аллергии
- кожный зуд;
- высыпания;
- отек Квинке (редко).
Кожный зуд — одна из возможных побочных реакций на прием препарата.
Особые указания
Нежелательно пользоваться препаратом пациентам при первичной стадии альдостеронизма и тяжелой форме гипотензии. Организм у таких больных невосприимчив к подобным медикаментам.
При корректировке дозы следует учитывать то, что гипотензивное действие лекарства набирает интенсивность спустя 4-7 недель после приема лекарства.
Совместимость с алкоголем
Нежелательно при курсе лечения таблетками пить спиртосодержащие напитки.
Влияние на способность управлять механизмами
Возможность управления сложными механизмами и автомобильным транспортом оценивается на основании индивидуальной реакции организма. Аналогичное касается и деятельности, требующей повышенной концентрации и быстрой психомоторной реакции.
Нежелательно при курсе лечения таблетками пить спиртосодержащие напитки.
Применение при беременности и в период лактации
Препарат не назначается при беременности. При лактации и назначении медикамента следует прекратить кормление грудью.
Назначение Телмисартана детям
Никаких клинических исследований относительно эффективности и безопасности лекарства на детский организм не проводилось.
В инструкции к препарату сказано, что в минимальных дозах им можно пользоваться в возрасте от 6 до 18 лет.
Применение в пожилом возрасте
Пациенты преклонного возраста не нуждаются в корректировке дозы медикамента. Исключением являются лишь больные с сердечной недостаточностью, при артериальной гипертензии и патологиях сердечно-сосудистой системы.
Пациенты преклонного возраста не нуждаются в корректировке дозы медикамента.
Передозировка
Не зафиксировано случаев смертности и тяжелых отрицательных проявлений при превышении дозы лекарства. В редких случаях может наблюдаться усиление дозозависимых побочных действий и повышение сосудистого тонуса. Симптомы передозировки проходят сами через 1-2 дня.
Взаимодействие с другими препаратами
В сочетании препарата с Дигоксином повышается концентрация последнего в кровяной плазме. Нежелательно комбинировать медикамент с диуретиками.
Сочетание лекарства с иными средствами для уменьшения артериального давления может вызвать слишком существенное уменьшение АД.
Сочетание лекарства с иными средствами для уменьшения артериального давления может вызвать слишком существенное уменьшение АД.
В комбинации с кортикостероидами сокращается антигипертензивный эффект препарата. При одновременном назначении ингибиторов АПФ пациенту требуется контроль клинических показателей.
Аналоги
Доступные российские и импортные синонимы лекарства:
Условия отпуска из аптеки
Реализуется лекарство по рецепту.
Цена на Телмисартан
Препарат стоит 6000 рублей за 1 пачку из 98 таблеток.
Условия хранения препарата
Хранить необходимо в защищенном от воды и света месте, куда не смогут добраться домашние животные и маленькие дети.
Срок годности
3 года после производства.
Производитель
Российская фармацевтическая компания "Северная звезда".
Отзывы врачей и пациентов о Телмисартане
В основном о лекарственном средстве отзываются положительно. При появлении побочных действий доктор подбирает замену медикаменту для понижения АД.
Лариса Коровина (кардиолог), 40 лет, Ижевск
Несмотря на высокую стоимость (если сравнивать его и другие российские лекарства), я часто выписываю этот рецепторов антагонист своим пациентам при подагре, гиперазотемии и многих иных болезнях. Побочных действий при его приеме не возникает, а давление нормализуется крайне оперативно.
Виктория Аскерова, 38 лет, Липецк
Телмисартан Плюс назначил кардиолог. Давление нормализовалось примерно через 1-1,5 недели после начала их приема, однако появились сильные головокружения. Пока еще не могу решить, продолжать терапию дальше или заменить средство. Но в моем случае сложно отыскать лекарственный препарат, который одновременно уменьшает артериальное давление и не влияет на функционирование сердечной мышцы. А этот медикамент обладает таким действием.
Алена Коврина, 45 лет, Сочи
Пользовалась медикаментом более года, никаких побочных реакций не наблюдалось, несмотря на множество сопутствующих болезней (от почечных камней до острого гастрита и заболевания органа слуха). АД перестало «скакать» уже через пару недель после начала приема лекарства. Принимаю по 1 пилюле в сутки.
| Вид товара: | Лекарственные средства |
| Действующие вещества: | Телмисартан |
| Производитель: | Северная Звезда, ЗАО |
| Страна происхождения: | Россия |
| Фармакотерапевтическая группа: | ангиотензина II рецепторов антагонист |
| Форма выпуска и упаковка: | Таблетки, 80 мг 28 штук в уп |
| Хранить в сухом месте: | Да |
| Хранить при комнатной температуре 15-25 градусов: | Да |
| Беречь от детей: | Да |
| Хранить в защищенном от света месте: | Да |
| Все аналогичные товары |
Аналогичные товары
КРКА, д.д., Ново место, АО
КРКА, д.д., Ново место, АО
КРКА, д.д., Ново место, АО
Берингер Ингельхайм Эллас А.Е
Берингер Ингельхайм Эллас А.Е
КРКА, д.д., Ново место, АО
Берингер Ингельхайм Эллас А.Е
Лабораториос Ликонса С.А.
Лабораториос Ликонса С.А.
Лабораториос Ликонса С.А.
Лабораториос Ликонса С.А.
Зентива Саалык Юрюнлери Санайи ве Тиджарет А.Ш.
Телмисартан-сз 0,08 n28 табл инструкция по применению
Лекарственная форма
Таблетки белого или почти белого цвета, круглые, плоскоцилиндрические, с фаской и риской.
Состав
активное вещество: телмисартан — 80 мг
вспомогательные вещества: натрия гидроксид — 6,8 мг; повидон-К30 (поливинилпирролидон среднемолекулярный) — 24,0 мг; меглюмин — 24,0 мг; маннитол — 330,4 мг; магния стеарат — 4,8 мг; тальк — 10,0 мг.
Фармакодинамика
Телмисартан — специфический антагонист рецепторов ангиотензина II (тип АТ1), эффективный при приеме внутрь. Обладает высоким сродством к подтипу АТ1 рецепторов ангиотензина II, через которые реализуется действие ангиотензина II. Вытесняет ангиотензин II из связи с рецептором, не обладая действием агониста в отношении этого рецептора.
Телмисартан связывается только с подтипом АТ1 рецепторов ангиотензина II. Связь носит длительный характер. Не обладает сродством к другим рецепторам, в том числе к АТ2 рецептору и другим, менее изученным рецепторам ангиотензина. Функциональное значение этих рецепторов, а также эффект их возможной избыточной стимуляции ангиотензином II, концентрация которого увеличивается при назначении телмисартана, не изучены. Снижает концентрацию альдостерона в крови, не ингибирует ренин в плазме крови и не блокирует ионные каналы. Телмисартан не ингибирует ангиотензинпревращающий фермент (кининаза II) (фермент, который также разрушает брадикинин). Поэтому усиление вызываемых брадикинином побочных эффектов не ожидается.
У пациентов телмисартан в дозе 80 мг полностью блокирует гипертензивное действие ангиотензина II.
Начало антигипертензивного действия отмечается в течение 3-х часов после первого приема телмисартана. Действие препарата сохраняется в течение 24 часов и остается значимым до 48 часов. Выраженный антигипертензивный эффект обычно развивается через 4-8 недель после регулярного приема внутрь.
У пациентов с артериальной гипертензией телмисартан снижает систолическое и диастолическое артериальное давление (АД), не оказывая влияния на частоту сердечных сокращений (ЧСС).
В случае резкой отмены телмисартана АД постепенно возвращается к исходному уровню без развития синдрома "отмены".
Фармакокинетика
При приеме внутрь быстро всасывается из желудочно-кишечного тракта. Биодоступность — 50%. При приеме одновременно с пищей снижение AUC (площадь под кривой "концентрация-время") колеблется от 6% (при дозе 40 мг) до 19% (при дозе 160 мг). Спустя 3 часа после приема концентрация в плазме крови выравнивается, независимо от времени приема пищи. Наблюдается разница в плазменных концентрациях у мужчин и женщин. Сmах (максимальная концентрация) и AUC были приблизительно в 3 и 2 раза, соответственно, выше у женщин по сравнению с мужчинами без значимого влияния на эффективность.
Связь с белками плазмы крови — 99,5%, в основном с альбумином и альфа-1 гликопротеином. Среднее значение видимого объема распределения в равновесной концентрации — 500 л. Метаболизируется путем конъюгирования с глюкуроновой кислотой. Метаболиты фармакологически неактивны. Период полувыведения — более 20 час. Выводится через кишечник в неизмененном виде, выведение почками — менее 2% от принятой дозы. Общий плазменный клиренс высокий (900 мл/мин) по сравнению с "печеночным" кровотоком (около 1500 мл/мин.).
Фармакокинетика телмисартана у пациентов пожилого возраста не отличается от молодых пациентов. Коррекции доз не требуется.
Пациенты с почечной недостаточностью
Изменение дозы у пациентов с почечной недостаточностью не требуется, включая пациентов, находящихся на гемодиализе. Телмисартан не удаляется с помощью гемодиализа.
Пациенты с печеночной недостаточностью
У пациентов с легкими и умеренными нарушениями функции печени (класс А и В по шкале Чайлд-Пью) суточная доза препарата не должна превышать 40 мг.
Применение в педиатрии
Основные показатели фармакокинетики телмисартана у детей в возрасте от 6 до 18 лет, после приема телмисартана в дозе 1 мг/кг или 2 мг/кг в течение 4 недель, в целом, сопоставимы с данными, полученными при лечении взрослых, и подтверждают нелинейность фармакокинетики телмисартана, особенно в отношении Сmах.
Побочные действия
Наблюдаемые случаи побочных эффектов не коррелировали с полом, возрастом или расовой принадлежностью пациентов.
Классификация частоты развития побочных эффектов Всемирной организации здравоохранения (ВОЗ): очень часто ≥1/10, часто от ≥1/100 до
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