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Причина возникновения нейротрофической язвы

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17 августа 2019

Термин «трофические язвы» объединяет в себе большую группу язвенных дефектов кожных покровов, которые являются осложнением заболеваний, а также повреждений сосудов и нервов, мягких тканей. Эта патология трудно поддается лечению, часто рецидивирует и может приводить к инвалидизации. В большинстве случаев язвы расположены на нижних конечностях. Трофические язвы венозного происхождения встречаются наиболее часто, данным заболеванием страдают около 2 % населения.

Причины образования язв

Существует множество заболеваний, которые при длительном тяжелом течении могут приводить к нарушению питания нижних конечностей, а в дальнейшем – к возникновению язвенных дефектов. Наиболее частыми являются:

  • хроническая венозная недостаточность (при врожденной патологии вен, варикозной болезни, после тромбоза);
  • болезни артерий (облитерирующий атеросклероз, поражение артерий при сахарном диабете, артериальной гипертензии);
  • нарушение оттока лимфы;
  • заболевания и травмы спинного и головного мозга, периферических нервов;
  • токсические полинейропатии;
  • травмы нижних конечностей с повреждением сосудисто-нервных пучков, мягких тканей (механические, химические, термические, лучевые);
  • инфекционные и паразитарные болезни (туберкулез, лепра, сифилис, лейшманиоз и др.).

Возможно возникновение трофических язв на фоне онкологических, ревматологических заболеваний, болезней крови, почечной, сердечной, печеночной недостаточности и др. В некоторых случаях данную патологию может вызывать несколько факторов, взаимодействующих между собой.

Механизмы образования язв

В основе расстройств питания тканей и образования их дефектов лежит нарушение микроциркуляции вследствие неадекватного оттока или притока крови, повышения давления в венах, нарушения иннервации. В результате этого резко снижается кровоток, развивается гипоксия, ишемия, некроз тканей. Бактериальное обсеменение тканей вызывает инфекционный процесс.

Клиническая картина

Заболевание имеет особенности течения в зависимости от причины появления трофических язв. Остановимся на основных из них.

Трофические язвы венозного характера

При недостаточности вен дефекты кожи располагаются на нижней трети голени (ее внутренней поверхности, реже — на задней и наружной части голени). Размеры язв могут меняться в процессе развития болезни. При длительном течении они могут распространяться на всю поверхность голени, а также вглубь тканей до мышц и надкостницы, в запущенных случаях провоцируя остеомиелит. Язвы болезненные, если они глубокие и обширные, то боль может не сниматься простыми анальгетиками, она уменьшается, если придать конечности возвышенное положение. Отделяемое из язвы может быть гнойным, кровянистым, это зависит от бактериального обсеменения, стадии раневого процесса.

Подтверждает зависимость данных нарушении от венозной недостаточности наличие варикозно расширенных вен, перенесенных глубоких венозных тромбозов.

Трофические язвы артериального характера

Чаще болеют лица мужского пола преклонного возраста. У больных имеются признаки артериальной недостаточности, а именно похолодание конечностей, их онемение, атрофия мышц, перемежающая хромота. Дефекты кожи обычно располагаются на стопе, при этом сохраняется пульсация большеберцовых артерий. Провоцируются эти изменения травматизацией кожи, ношением тесной обуви, переохлаждением. Боль в области язвенных дефектов усиливается при ходьбе, придании конечности возвышенного положения.

Диабетические трофические язвы

Язвенные дефекты располагаются на конечных фалангах пальцев стопы, могут быть очень глубокими и доходить до кости, но болевые ощущения практически отсутствуют. При этом нет признаков сосудистой недостаточности, но есть сахарный диабет.

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Гипертонические трофические язвы

В основе болезни лежит злокачественная артериальная гипертензия с высокими цифрами артериального давления, чаще болеют женщины 40-60 лет. Язвы локализуются на наружной поверхности голеней (спереди или сзади), характерно поражение обеих конечностей. Гипертонические язвы крайне болезненные, болевой синдром настолько выражен, что может приводить к психологическим расстройствам.

Нейротрофические язвы

Язвенные дефекты локализуются в зонах с нарушенной иннервацией, на подошве, пяточной кости, обычно они небольшие, но глубокие (в виде кратера). В зоне повреждения нарушены все виды чувствительности.

Инфекционные трофические язвы

Язвы появляются на фоне низкого иммунитета, чаще у асоциальных больных, в результате инфицированных повреждений кожи, пиодермии, микробной экземы и др. Для них характерно наличие отделяемого гнойного характера и лихорадки у больного. Располагаться язвы могут по всей поверхности голеней или концентрироваться группами, сопровождаются увеличением и болезненностью регионарных лимфоузлов.

Диагностика

Врач устанавливает диагноз на основании типичной клинической картины, объективного обследования. Для уточнения природы язв может назначаться дополнительное обследование. Обязательным является определение пульсации артерий стоп. Больным назначаются лабораторные анализы (общий анализ крови, мочи, анализ крови на сахар и биохимию). Для подтверждения сосудистого характера язв назначается ультразвуковая допплерография, ультразвуковое дуплексное ангиосканирование, рентгенконтрастная флебография. Следует учитывать, что около 15 % всех язв имеют смешанное происхождение.

Лечение

Лечение может проводиться как на дому, так и в стационаре, на это влияет тяжесть процесса. Лечебные мероприятия зависят от причины заболевания, но имеют определенные общие черты.

  1. Всем больным показан покой и постельный режим.
  2. Ежедневный туалет язвы, сухая ватно-марлевая повязка.
  3. Системная антибактериальная терапия (назначаются препараты широкого спектра действия – цефалоспорины, пенициллины).
  4. Неспецифическая противовоспалительная терапия (диклофенак, ревмоксикам, нимесулид, иногда кортикостероиды в низких дозах).
  5. Десенсебилизирующая терапия (тавегил, супрастин, цетиризин и др.).
  6. Местное лечение (многокомпонентные мази с антибиотиками, кортикостероидами, ванночки с антисептиками и др.).
  7. Хирургическое лечение при отсутствии эффекта от медикаментозного или в сочетании с ним.

При венозных язвах обязательным является эластическая компрессия, при отсутствии гнойного процесса, до полного заживления, назначаются дезагреганты (аспирин, клопидогрель, пентоксифиллин), венотоники (детралекс, троксевазин и др.), актовегин и др. Артериальные язвы должны лечиться в отделениях сосудистой хирургии, лечение может быть медикаментозное (дезагреганты, антикоагулянты, простагландины и др.) и хирургическое.

Диабетические язвы лечатся в условиях хирургического стационара, первостепенное значение имеет нормализация уровня глюкозы. При наличии гипертонических язв необходимо лечить артериальную гипертензию.

Физиотерапевтическое лечение

Лечение физическими факторами направлено на улучшение микроциркуляции и регенерации в зоне язвенного дефекта, нормализацию притока и оттока крови, уменьшение воспаления в тканях.

Методы, уменьшающие воспаление:

  • УФО в эритемных дозах;
  • СВЧ и УВЧ-терапия.

Методы, оказывающие бактерицидное действие:

  • лекарственный электрофорез с антибактериальными средствами, протеолитическими ферментами (способствует очищению язвы от омертвевших тканей);
  • местная дарсонвализация;
  • аэроионотерапия местного действия;
  • наружная аэрозольтерапия.

Методы, способствующие расширению сосудов:

  • ультратонотерапия;
  • лекарственный электрофорез с вазодилятаторами (никотиновая кислота, дибазол и др.);
  • инфракрасное облучение;
  • гальванизация.

Методы, способствующие процессам заживления:

  • воздушные ванны;
  • озоновые ванны;
  • гелиотерапия.

Заключение

В заключении хотелось бы отметить, что лечение трофических язв — процесс длительный и крайне сложный, больные должны строго соблюдать рекомендации врача. При длительном течении и отсутствии лечения язвы могут малигнизироваться (становиться злокачественными).

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Программа «Школа здоровья» на тему «Венозные трофические язвы»:

Программа «Будьте здоровы» на тему «Трофические язвы»:

Под трофикой понимают питание тканей, в частности покровов, поэтому всякую язву, развивающуюся вследствие нарушения питания тканей, независимо от причин, вызвавших это нарушение, называют трофической. К этой группе обычно относят долго не заживающие язвы, образовавшиеся после ожогов, отморожений и длительных нагноений.

Нейротрофической язвой, в узком смысле этого слова, следует называть язву, возникающую вследствие нарушения функций симпатической или чувствительной нервной системы.

Поводом, к развитию нейротрофической язвы могут служить повреждения или заболевания центральной нервной системы (опухоли, миэлиты), невриты и механические повреждения периферических нервов. Нейротрофическая язва особенно часто развивается в случаях, когда центральный конец поврежденного нерва продолжительно раздражен: а) бактерийными токсинами; б) давлением рубцовой ткани; в) химическими веществами; г) постоянным сокращением мускулов при сращении с ними поврежденного нерва; д) образованием мелких невром на месте ранения нервов.

Имеются указания, что заболевания и повреждения нервной системы неизбежно сопровождаются вазомоторной реакцией. Она выражается в изменении кровяного давления, сосудистого тонуса и температуры конечности ниже места повреждения. Сужение сосудов, которое наблюдается после кратковременного их расширения, нарушает циркуляцию крови и лимфы, что в свою очередь создает благоприятную почву для развития глубоких деструктивных процессов и трофических расстройств. Первенствующее значение в возникновении и развитии трофических расстройств имеет центральная нервная система. Она может при известных условиях, совершенно независимо от состояния кровоснабжения тканей в области язвы, понизить биологическую активность клеток, нарушить их состав и строение и создать, таким образом, условия для их разрушения. С другой стороны, нервная система может повысить жизнедеятельность клеток и этим усилить их рост и размножение.

Патологоанатомические изменения в периферической нервной системе при трофических язвах могут быть весьма различными. В одних случаях они представляют собой едва распознаваемые под микроскопом токсические невриты, в других — грубые дегенеративные изменения нервных стволов. В дальнейшем последние могут превратиться в соединительнотканные шнуры на месте повреждения, если оно сопровождалось надрывом, ущемлением или полным разрывом того или иного нерва или же повлекло за собой развитие тяжелого неврита.

Свежая нейротрофическая язва покрыта вялыми, бледными, с цианотическим оттенком грануляциями и выделяет значительное количество грязносерого слизисто-гнойного экссудата. Края язвы подрыты или истончены. Ткани по окружности язвы отечные и совершенно безболезненны. Регенерация кожного эпителия отсутствует.

Хроническая язва имеет чаще всего округлую форму, слегка утолщенные края и выделяет ничтожное количество серозно-слизистого экссудата. Зернистость грануляционной ткани незаметна даже при осмотре поверхности язвы под лупой. Болезненность обычно отсутствует, вследствие чего животное выполняет работу, не проявляя никаких болевых ощущений. Хронические нейротрофические язвы у лошадей сопровождаются атрофией кожи в области поражения. Кожа сохраняет подвижность, но становится сухой и очень тонкой (личное наблюдение).

Если очаг раздражения в каком-либо участке проводящих нервных путей поддерживается инородным телом или невритом, то трофическая язва весьма болезненна. Лечение язвы обычными средствами (высушивающие, дезинфицирующие мази, ультрафиолетовое облучение, лампа соллюкс) не приносит пользы.

Нейротрофическая язва имеет наклонность прогрессировать, распространяться по поверхности и в глубину. Она может существовать годами без тенденции к заживлению.

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Лечение. В ветеринарной практике получили наибольшее распространение следующие способы.

Круговое рассечение тканей по окружности язвы. Ткани рассекают на расстоянии 4—12 см по окружности язвы. Джанелидзе считает возможным зашивать рану тотчас же после рассечения тканей, что значительно ускоряет заживление операционной раны и в то же время не снижает терапевтического эффекта в отношении трофической язвы.

По литературным данным, трофические язвы заживают после окаймляющих разрезов в 50% случаев. Благоприятные результаты после этой операции объясняются следующим: 1) вокруг язвы перерезаются симпатические нервные волокна; 2) после кожного разреза наступает гиперемия вследствие травмы и перерезки мелких кожных нервов; 3) перерезаются отходящие от язвы вены, благодаря чему область язвы сразу выключается из зоны венозного обратного тока и получает неизмененную артериальную кровь из капилляров сосудов глубокорасположенных тканей.

Новокаиновый блок по Вишневскому и тканевая терапия.

Лечение трофических язв пересадкой сальника. Применяют гомо- и гетеротрансплантацию свежего и консервированного (на холоду) сальника. Пересадка сальника оказывает очень хорошее действие на старые трофические язвы, не поддававшиеся общепринятым способам лечения. Сальник, свободно пересаженный на поверхность трофической язвы, выполняет роль биологического стимулятора заглохшего регенеративного процесса. Он возбуждает рост грануляций и кожного эпителия и в то же время сохраняет свои пластические свойства. Под его влиянием начинают быстро развиваться на дне язвы здоровые, ярко-красные грануляции, а с периферии и в центре язвы — кожный эпителий.

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Нейротрофическими называются язвы, появление которых связано с нарушением иннервации части тела (чаще всего конечности).

Причины нейротрофических язв

– поражение или травма спинного мозга, нервных стволов. На фоне отсутствия иннервации нарушаются обменные процессы в тканях, что ведет к гипоксии, некробиозу и некрозу.

Симптомы, диагностика

Нейротрофические язвы появляются на участках тела, испытывающих повышенное давление – чаще всего на подошвенной поверхности стоп. Провоцирующим фактором может послужить незначительная травма (ушиб, ссадина), ношение тесной обуви, длительная ходьба, попадание в обувь мелких предметов (камушек), которые часто остаются незамеченными пациентами с пониженной поверхностной и глубокой чувствительностью. Язвы вначале небольших размеров, но им свойственно увеличиваться как в ширину, так и в глубину, вплоть до поражения костей. Отделяемое обычно скудное, характерно наличие вялых грануляций, нарушения процессов эпителизации с краев. Дно и стенки язвы бледные, часто серого оттенка. Характерно отсутствие болей в области язвы.

Лечение нейротрофических язв

Должно проводиться совместно хирургом и невропатологом (нейрохирургом). Обязательно сочетание как местного лечения, так и системной терапии, направленной на улучшение нейротрофических процессов, микроциркуляции крови в пораженной части тела.

Назначают витамины группы В (мильгамма), никотиновую кислоту, препараты, улучшающие микроциркуляцию (трентал), средства, стимулирующие регенерацию тканей (солкосерил). Местно проводят перевязки с различными лечебными средствами, в зависимости от состояния раны. Возможны хирургические методы – шов нерва, невролиз, кожная пластика. В последнее время изучается возможность лечения нейротрофических язв стволовыми клетками.

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