- 3 Июня, 2019
- Кардиология
- Смирнова Александра
При заболеваниях и патологическом изменении сердечно-сосудистой системы, сопровождающихся повреждением миокарда и ишемическими острыми нарушениями, а кроме того, дисфункцией мозгового кровообращения, помогает «Идринол». В составе этого лекарства есть активный ингредиент в виде мельдония, который знаменит своим свойством высвобождения энергии на клеточном уровне, что позволяет ускорять метаболизм и избегать застойного процесса в тканях. Для каких целей применяют этот препарат, как правильно его нужно использовать и какие меры осторожности требуется соблюдать, разберемся далее.
Форма выпуска
Выпуск препарата «Идринол» осуществляют в форме раствора, предназначенного для инъекций. Помимо этого, медикамент продается в виде капсул. В обеих лекарственных вариантах главным действующим веществом выступает особое соединение в виде дигидрата мельдония.
Раствор для уколов
Итак, «Идринол» выпускается в виде прозрачного раствора, который подходит для парабульбарного и внутривенного способа введения. В одной лекарственной ампуле содержится 500 миллиграмм дигидрата мельдония, а также вода, необходимая для инъекций. Каждая ампула упаковывается в картонные контурные пачки по пять или десять штук в каждой. Инструкция по применению к уколам «Идринол» также вложена в упаковку.
Капсулы
Помимо инъекций представленное фармацевтическое средство может продаваться в виде капсул. Действующее вещество у них такое же, что и в растворе. Согласно инструкции по применению, таблетка «Идринол» содержит 250 миллиграмм активного компонента. А вспомогательными ингредиентами выступают картофельный крахмал наряду с диоксидом кремния коллоидным и стеаратом кальция. Состав оболочки капсулы делается из диоксида титана и желатина. Сами пилюли имеют белый цвет.
Фармакологическое воздействие препарата
В соответствии с инструкцией по применению к «Идринолу», мельдоний, который является главным компонентом средства, выступает искусственным аналогом особого вещества под названием бутиробетан, присутствующего во всех клетках организма человека. Данное вещество выполняет ряд важнейших функций. Оно подавляет продуцирование карнитина наряду с переносом некоторых жирных кислот через мембраны клеток. Это ведет к снижению в них активированных форм биологических жидкостей, не подвергшихся процессам окисления.
При разных нарушениях кровообращения активный ингредиент «Идринола» позволяет устранить последствие ишемии благодаря восстановлению баланса между поступлением в ткани кислорода и его употреблением клетками. Активное вещество оказывает выраженное сосудорасширяющее воздействие. Кроме этого, оно повышает скорость обменных процессов и предотвращает формирование атеросклеротических бляшек на сосудистых стенках.
Как указывает инструкция по применению «Идринола», активное вещество рассматриваемого препарата способствует улучшению сократительных функций миокарда сердца, в связи с этим снижается количество приступов стенокардии и повышается общая толерантность человеческого организма к различным нагрузкам. Действующий компонент способствует улучшению сократительных функций. При инфаркте миокарда применение «Идринола» позволяет замедлять формирование некрозов, препятствуя появлению обширного очага повреждения органа.
Благодаря улучшению текучести крови действующий компонент этого медикамента способствует улучшению качества питания некротизированных участков мозга при остром либо хроническом сбое церебрального кровоснабжения. Помимо этого понижается выраженность отечного синдрома, который часто наблюдается у пациентов при инсульте.
В результате сложных биохимических реакций ткани, которые поражены ишемическими процессами, начинают насыщаться кислородом и питательными компонентами намного лучше благодаря перенаправлению к ним кровотока. За счет этого ишемический приступ в головном мозге протекает с менее разрушительными последствиями, чем на фоне инсульта, который своевременно не был купирован. Лекарство оказывает положительный эффект и при лечении сосудистых заболеваний глазного дна.
Фармакокинетика
Как нам сообщает инструкция по применению, «Идринол» прекрасно всасывается в кровь и достигает своей максимальной концентрации, как правило, уже в первые десять-пятнадцать минут после употребления. Метаболизируется лекарство спустя три часа в печени с последующим формированием двух малоактивных метаболитов, которые в дальнейшем будут выведены почками через шесть часов.
Преимущества
«Идринол» относят к группе фармацевтических лекарств, которые улучшают кровообращение наряду с метаболизмом и энергообеспечением на клеточном уровне. Его действующий компонент мельдоний может благоприятно отражаться на всей кровеносной системе человека. Помимо этого описываемое лекарство обладает набором следующих положительных терапевтических свойств:
- Нормализация процесса поглощения и высвобождения в клетке кислорода.
- Восстановление дисбаланса транспортировки аденозинтрифосфорных кислот.
- Усиление гликолиза, протекающего без дополнительной траты кислорода.
- Замедление синтеза карнитина, что дает возможность снижать застойный процесс в клетках, вызванный лишним накапливанием жирных неокисленных кислот.
Все вышеперечисленные процессы на микроуровне обеспечивают заметный результат:
- Стабилизация самочувствия пациентов, при этом у них отмечается прилив сил наряду с увеличением жизненной энергии.
- Нормализация мозговой активности в сочетании с улучшением памяти и концентрации внимания.
- Налаживается давление.
При применении «Идринола» в процессе реабилитации и устранения последствий инфаркта препарат может предотвратить некротические патологии сердца. На фоне этого процесс восстановления в значительной мере сокращается. Помимо всего прочего, представленный медикамент используется при терапии хронического алкоголизма, что позволяет пациентам избавляться от осложнений процесса, а также нормализует все нейрогуморальные реакции в организме.
Показания к назначению уколов
Согласно инструкции по применению уколов «Идринол», рассматриваемый фармацевтический препарат используется в форме инъекций при лечении следующих патологий и состояний:
- На фоне хронической усталости, перенапряжения, потери жизненных сил (в особенности среди спортсменов и людей, работа которых связана с большими физическими нагрузками).
- Нарушение работоспособности сердца из-за ишемической болезни в виде стенокардии, инфаркта, кардиомиопатии.
- Заболевания, которые вызваны патологическим сбоем мозгового кровоснабжения. Речь идет об инсультах, цереброваскулярной недостаточности и т. п.
- Нарушение питания глазных мышц и патологий глаза в форме тромбоза венозной сетчатки, ретинопатии, кровоизлияний внутри зрительного органа и так далее.
В составе комплексного лечения данный препарат используют в роли вспомогательного средства при терапии хронической формы алкоголизма. Это также подтверждает инструкция по применению к «Идринолу». Он действует таким образом, что увеличивает кровяной приток к мозгу, а также высвобождает энергию непосредственно на клеточном уровне. Это и помогает снимать синдром апатии и хронической усталости у пациентов.
Показания к использованию капсул
В области неврологии в рамках комплексного лечения данный медикамент в капсулах назначается больным при ишемическом и геморрагическом инсульте в восстановительном периоде. Показанием («Идринол» можно употреблять только после консультации врача) также является преходящее нарушение мозгового кровообращения. В сфере кардиологии в составе комплексной терапии эти капсулы применяют от стенокардии, хронической недостаточности сердца и дисгормональной кардиомиопатии.
Помимо всего прочего, «Идринол» в капсулах назначается при пониженной работоспособности, на фоне физического перенапряжения, а также в рамках послеоперационного периода для ускорения реабилитации. Наличие абстинентного алкогольного синдрома также предполагает использование данной лекарственной формы в комбинации со специфическим лечением.
Инструкция по применению таблеток «Идринол» и ампул
Учитывая то, что воздействием препарата предполагается освобождение дополнительной энергии, что вызывает возбудимость, его использовать лучше в первой половине дня. Дозировка с продолжительностью курса напрямую зависит от заболевания и особенностей организма пациента. В рамках терапии «Идринолом» во внимание должны приниматься следующие рекомендации:
- Необходимое количество препарата назначается врачом.
- При пониженной работоспособности и увеличенной физической и нейрогуморальной нагрузке используется по 5 миллиграмм раствора внутривенно однократно в сутки. Общая длительность курса лечения при этом не должна превышать двух недель.
- В рамках комплексной терапии для борьбы с сердечно-сосудистыми заболеваниями используется от 3 до 5 миллилитров внутривенно. Это количество лекарства разделяют на два приема (по утрам и вечерам). Курс составляет от десяти до четырнадцати суток.
- При нарушении мозгового кровообращения медикамент «Идринол» в ампулах вводится по 5 миллилитров в вену за один раз, продолжительность составляет не более десяти дней, после чего требуется сделать перерыв минимум на один месяц.
- Наличие заболеваний глаз требует парабульбарного ввода препарата (то есть в область под нижнее веко), объем — от 0,5 до 1,5 миллилитра, продолжительность равна десяти дням.
- В целях ликвидации последствий терапии хронического алкоголизма используется «Идринол» внутримышечно по 5-7 миллилитров вещества внутривенно длительностью в одну неделю.
Подобрать оптимальное дозирование способен только врач с учетом состояния прогрессирования патологии, а также индивидуальных особенностей каждого пациента. Самолечение способно за собой повлечь целый ряд негативных побочных проявлений.
Прием препарата при диабете
Пациентам, которые страдают диабетом второго типа, лечение «Идринолом» может назначаться в дозировке 250 миллиграмм в сутки. При данном диагнозе рассматриваемый медикамент используют только в составе комплексного лечения для улучшения процесса метаболизма в организме.
«Идринол»: до еды или после принимать?
Употребление пищи никакого влияния на скорость процесса всасывания активных ингредиентов препарата не оказывает. В связи с этим он принимается вне зависимости от питания.
Лекарственное взаимодействие
С большой осторожностью сочетают это лекарство с препаратами в виде «Нифедипина», «Нитроглицерина» и гипертензивных средств. Рассматриваемый медикамент может хорошо сочетаться с антикоагулянтами, диуретиками, спазмолитиками, бронхолитиками. Это лекарство способно усилить активность сердечных гликозидов.
Применение лекарства «Идринол» допускается и с успокоительными фармацевтическими средствами, например с «Персеном». Описываемый препарат повышает эффективность сердечных гликозидов. С осторожностью следует комбинировать его прием с альфа-адреноблокаторами, с периферическими вазодилататорами, так как такое сочетание способно провоцировать тахикардию наряду со снижением давления.
Побочные действия
Обычно описываемое лекарство очень хорошо переносится всеми пациентами и лишь в отдельных случаях (что крайне редко) может вызывать следующие побочные реакции:
- Появление тахикардии и скачков давления.
- Возникновение психомоторного перевозбуждения, бессонницы, агрессии.
- Наличие аллергических реакций в виде крапивницы, ангионевротического отека, анафилаксии.
- Расстройство кишечника в форме диареи.
- Возможные побочные проявления наподобие бессонницы и агрессии.
Чтобы понизить риск от возможных негативных реакций, первоначальное употребление данного препарата производится в медицинском учреждении под строгим контролем врачей. При аллергии на те или иные медицинские препараты в анамнезе терапию начинают лишь после того, как будет сделана аллергопроба, которая показывает отсутствие ярко выраженной несовместимости с препаратом.
Помимо всего прочего, побочные проявления могут отмечаться на фоне самостоятельного увеличения дозировки и превышения суточной нормы. При этом может отмечаться скачкообразное изменение показателей давления наряду с тахикардией и дискомфортом в сердце, а также сильной головной болью в затылочной доле. Лечение в данном случае понадобится симптоматическое, оно должно заключаться в скорейшем понижении концентрации в крови мельдония (капельницы с физиологическим раствором).
Противопоказания
Нельзя применять инъекции «Идринола» в процессе лечения при следующих заболеваниях:
- Наличие у пациента онкологического новообразования.
- Нарушения венозного оттока.
- Повышенное внутричерепное давление.
- Детский возраст до восемнадцати лет.
С большой осторожностью и исключительно под контролем врача инъекции с «Идринолом» вводятся пациентам, которые страдают нарушением функционирования почек, а также при недостаточности печени.
При беременности
Сведений о возможном воздействии «Идринола» на развитие плода на сегодняшний день нет, поэтому его применение в период беременности крайне нежелательно. Также еще не было выявлено, всасывается ли активный компонент лекарства в грудное молоко. В связи с этим в том случае, если существует необходимость его употребления в период лактации, малыш переводится на искусственное вскармливание.
Особые указания
С большой осторожностью применяется рассматриваемое средство при заболевании печени и почек, в особенности если его надо использовать в течение продолжительного времени. Многолетний опыт терапии нестабильной стенокардии и острого инфаркта в кардиологических отделениях демонстрирует, что мельдоний средством первого ряда при наличии острого коронарного синдрома не является.
Условия и срок хранения
Ампулы и капсулы с данным препаратом хранятся в целостном виде при температуре воздуха не более двадцати градусов. Их нужно беречь от детей, а кроме того, от попадания солнечных прямых лучей. Срок годности медикамента составляет тридцать шесть месяцев с даты изготовления. Препарат отпускают в аптеках строго по докторскому рецепту.
Стоимость одной упаковки, состоящей из пяти ампул, составляет от ста шестидесяти до ста восьмидесяти рублей. За капсулы необходимо заплатить около ста рублей.
Аналоги медикамента
Аналогами «Идринола» являются «Милдронат» наряду с «Кардионатом», «Ангиокардилом», «Мельфором», «Медатерном» и «Мидолатом». Подбирать замену должен врач.
Далее познакомимся с мнениями потребителей и узнаем, что они рассказывают об этом медикаменте.
Отзывы
Пациенты, которые используют «Идринол» и аналоги в рамках терапии, сообщают, что их высокая эффективность, как правило, отмечается уже после первого применения. В комментариях люди пишут, что описываемый нами медикамент позволяет нормализовать артериальное и внутричерепное давление, устраняя последствия ишемического заболевания, а также медикамент хорошо справляется с различными глазными патологиями, усиливая кровоснабжение зрительных органов.
Помимо заявленного лекарственного воздействия это фармацевтическое средство заметно повышает жизненный тонус, давая людям дополнительную энергию, а также позволяя справляться с нейрогуморальным расстройством.
Таким образом, в том случае, если строго следовать инструкции и указаниям доктора, препарат «Идринол» может послужить отличным медикаментозным средством при сердечно-сосудистых патологиях и нарушениях кровообращения в мозге. Лекарство является действенным не только в роли лечебного средства, но и в качестве профилактики различных расстройств и физического переутомления.
При болезнях и патологических изменениях сердечно-сосудистой системы, которые сопровождаются повреждением миокарда сердца и острыми ишемическими нарушениями, а также дисфункциями мозгового кровообращения, поможет Идринол.
Этот препарат содержит в себе активный препарат – мельдоний, знаменитый своими свойствами высвобождать энергию на клеточном уровне, позволяя ускорить метаболизм и избежать застойных процессов в тканях.
Для каких целей используется Идринол, как правильно использовать и какие меры предосторожности нужно соблюдать, разберем далее.
Инструкция по применению
Идринол относится к группе фармацевтических препаратов, улучшающих кровообращение, метаболизм и энергообеспечение на клеточном уровне.
Его активный компонент – мельдоний, способен благоприятно влиять на всю кровеносную систему:
Нормализует процесс поглощения и высвобождения кислорода в клетке.- Восстанавливает дисбаланс транспортировки аденозинтрифосфорной кислоты.
- Усиливает гликолиз, протекающий без дополнительных затрат кислорода.
- Замедляет синтез карнитина, что позволяет снизить застойные процессы в клетках, вызванные излишним накапливанием неокисленных жирных кислот.
Нормализует процесс поглощения и высвобождения кислорода в клетке.Все эти процессы на микроуровне дают такой результат, который заметен снаружи:
- улучшается самочувствие, отмечается прилив сил и увеличение жизненной энергии;
- нормализуется мозговая активность, улучшается память и концентрация внимания;
- нормализуется давление.
При использовании Идринола в реабилитации и ликвидации последствий инфаркта миокарда, препарат способен предотвращать некротические формирования сердца. При этом процесс реабилитации значительно сокращается.
Также Идринол используют при лечении хронического алкоголизма, позволяя пациенту избавиться от осложнений процесса, а также нормализовать все нейрогуморальные процессы.
Идринол хорошо всасывается в кровь, достигая максимальной концентрации в первые 10-15 минут после приема препарата.
Метаболизируется через 2-3 часа в печени, с образованием двух метаболитов (малоактивные), которые в дальнейшем выводятся почками через 5-6 часов.
Показания к применению
Препарат используют при лечении следующих заболеваний и патологических состояний:
- хроническая усталость, перенапряжение, потеря жизненных сил (особенно у спортсменов и людей, чья работа связана с повышенными физическими нагрузками);
- нарушения работоспособности сердца на фоне ишемической болезни: стенокардия, инфаркт, кардиомиопатия;
- заболевания, вызванные патологическими нарушениями мозгового кровоснабжения: инсульт, цереброваскулярная недостаточность;
- нарушения питания глазной мышцы и следующих заболеваний глаза: тромбоз венозной сетчатки, ретинопатия, внутриглазные кровоизлияния.
В составе комплексной терапии препарат используется в качестве вспомогательного средства при лечении хронического алкоголизма, увеличивая приток крови к мозгу, а также высвобождая энергию на клеточном уровне. Это помогает снять синдром хронической усталости и апатии.
Способ
Поскольку действие препарата предполагает высвобождение дополнительной энергии, что ведет за собой возбудимость, его применение лучше осуществлять в первой половине дня.
Дозировка и продолжительность курса приема напрямую зависит от заболевания и особенностей организма пациента:
- тахикардия и скачки давления;
- психомоторное перевозбуждение, бессонница, агрессия;
- аллергические реакции: крапивница, ангионевротический отек, анафилаксия;
- расстройства кишечника в виде диареи.
- онкологические новообразования;
- нарушение венозного оттока и повышенного внутричерепного давления;
- детский возраст до 18 лет.
- активное вещество: мельдония дигидрат – 100 мг, что соответствует содержанию мельдония безводного – 80,21 мг;
- дополнительный компонент: вода для инъекций.
- кардиопротекторное действие;
- активация гуморального и тканевого иммунитета;
- уменьшение симптомов умственного и физического перенапряжения;
- повышение работоспособности.
- физическое перенапряжение (в том числе у спортсменов);
- сниженная работоспособность;
- тромбоз центральной вены сетчатки и ее ветвей, гемофтальм и кровоизлияния в сетчатку глаза различной этиологии, ретинопатии различной этиологии (диабетическая, гипертоническая);
- острое нарушение мозгового кровообращения: ишемический инсульт и цереброваскулярная недостаточность (в составе комплексной терапии);
- дисгормональная кардиомиопатия, хроническая сердечная недостаточность;
- ишемическая болезнь сердца: стенокардия, инфаркт миокарда (в составе комплексной терапии);
- синдром абстиненции при хроническом алкоголизме (в сочетании со специфической терапией).
- повышение внутричерепного давления (при нарушении венозного оттока и внутричерепных опухолях);
- гиперчувствительность к компонентам препарата;
- возраст до 18 лет.
- нарушения мозгового кровообращения: в острой фазе – по 500 мг (5 мл раствора) 1 раз в сутки на протяжении 10 дней;
- умственные и физические нагрузки (в т. ч. у спортсменов): по 500 мг 1 раз в сутки в течение 10–14 дней;
- сердечно-сосудистые заболевания: по 500–1000 мг в 1–2 введения курсом 10–14 дней. По рекомендации врача возможно проведение повторных терапевтических курсов (2–3 раза в год);
- абстинентный синдром при хроническом алкоголизме: по 500 мг 2 раза в сутки на протяжении 10–14 дней.
- аллергические реакции: редко – кожные высыпания, гиперемия и зуд кожных покровов, ангионевротический отек; очень редко – эозинофилия;
- со стороны центральной нервной системы: редко – психомоторное возбуждение;
- со стороны сердечно-сосудистой системы: редко – повышение или снижение артериального давления, тахикардия;
- со стороны пищеварительной системы: редко – диспепсические нарушения;
- прочие: очень редко – общая слабость.
Состав и форма выпуска
Идринол выпускают в виде прозрачного раствора, предназначенного для внутривенного и парабульбарного способа введения. В одной ампуле препарата содержится 500 мг мельдоний дигидрата, а также вода для инъекций.
Каждая ампула упакована в контурные картонные упаковки, по 5 или 10 штук в каждой.
Лекарственное взаимодействие
С осторожностью сочетать с такими препаратами, как:
Хорошо сочетается с антикоагулянтами, спазмолитиками, диуретиками, бронхолитиками. Препарат способен усиливать активность сердечных гликозидов.
Побочные действия
Обычно препарат хорошо переносится пациентами, лишь в отдельных случаях (крайне редко) могут проявляться такие побочные реакции, как:
Чтобы снизить риски от возможных побочных реакций, первоначальный прием препарата производят в медицинском учреждении под контролем врачей.
При наличии аллергической реакции на любые мед препараты в анамнезе пациента, лечение начинают только после того, как будет проведена алерго-проба, показавшая отсутствие ярко выраженной аллергической реакции на препарат.
Также побочные реакции могут отмечаться при самостоятельном увеличении дозировки и превышении суточной нормы.
При этом отмечается скачкообразное изменение давления, тахикардия и боль в сердце, а также сильная головная боль в затылочной доле.
Лечение – симптоматическое, заключается в скорейшем снижении концентрации мельдония в крови (капельницы с физраствором).
Противопоказания
Нельзя использовать Идринол в терапии при наличии таких заболеваний, как:
С особой осторожностью и под чутким контролем специалистов инъекции с Идринолом вводят пациентам, с нарушениями функционирования почек и при печеночной недостаточности.
При беременности
Данных о возможном влиянии Идринола на развитие плода нет, поэтому его использование в период беременности нежелательно.
Также не выявлено, всасывается ли мельдоний в грудное молоко, если есть необходимость его приема в период лактации, ребенка переводят на искусственное вскармливание.
Условия и сроки хранения
Ампулы хранят в целостном виде, при температуре не более 25°С. Беречь от детей и от попадания прямых солнечных лучей. Срок годности – 36 месяцев с даты изготовления.
Препарат отпускается в аптеках строго по рецепту врача.
Стоимость упаковки из 5 ампул в России составляет 160-180 рублей.
В украинских аптеках препарат можно приобрести за 200-250 гривен.
Аналоги
Препараты, оказывающие аналогическое Идринолу воздействие на организм, являются:
Отзывы
Пациенты, использующие Идринол в терапии, утверждают, что его высокая эффективность отмечается после первого приема.
Он позволяет нормализовать внутричерепное и артериальное давление, устраняет последствия ишемической болезни, а также хорошо справляется с глазными заболеваниями, усиливая глазное кровоснабжение.
Итоги
Помимо основного лекарственного воздействия, Идринол повышает жизненный тонус, дает дополнительную энергию, а также позволяет справиться с нейрогуморальными расстройствами.
Таким образом, если следовать инструкции и указаниям врача, Идринол может стать отличным лекарственным средством при сердечно-сосудистых патологиях и нарушении кровообращения в мозге.
Эффективен не только в качестве лекарственного средства, но и как профилактика нейрогуморальных расстройств и физического переутомления.
Идринол: инструкция по применению и отзывы
Латинское название: Idrinol
Действующее вещество: Мельдоний
Производитель: ЗАО «ФармФирма «Сотекс» (Россия)
Актуализация описания и фото: 18.10.2018
Цены в аптеках: от 98 руб.
Идринол – метаболическое средство.
Форма выпуска и состав
Лекарственная форма – раствор для внутривенного и парабульбарного введения: прозрачная бесцветная жидкость (по 5 мл в ампулах из бесцветного стекла, по 5 ампул в контурных ячейковых упаковках, 1 или 2 упаковки в картонной пачке).
В 1 мл раствора содержатся:
Фармакологические свойства
Фармакодинамика
Мельдоний является структурным аналогом гамма-бутиробетаина – вещества, которое присутствует в каждой клетке человеческого организма.
Мельдоний активирует гликолиз, который протекает без дополнительного потребления кислорода, препятствует накоплению в клетках активированных форм неокисленных жирных кислот – производных ацилкарнитина и ацилкоэнзима A, снижает транспорт длинноцепочечных жирных кислот через оболочки клеток, подавляет гамма-бугиробетаингидроксигеназу, уменьшает синтез карнитина. В условиях ишемии предупреждает нарушение транспорта аденозинтрифосфорной кислоты (АТФ), восстанавливает равновесие процессов доставки кислорода и его потребления в клетках.
Вследствие снижения концентрации карнитина начинает усиленно синтезироваться гамма-бутиробетаин, обладающий вазодилатирующим свойством.
Механизм действия определяет многообразие фармакологических эффектов мельдония, таких как:
При сердечной недостаточности Идринол увеличивает толерантность к физической нагрузке, улучшает сократимость миокарда, снижает частоту приступов стенокардий.
В случае острого ишемического повреждения миокарда препарат замедляет образование зоны некроза, а также сокращает реабилитационный период.
При ишемических нарушениях мозгового кровообращения (как острых, так и хронических) улучшает циркуляцию крови в очаге ишемии.
Мельдоний эффективен при сосудистых патологиях глазного дна.
У больных хроническим алкоголизмом препарат устраняет функциональные нарушения нервной системы в период абстиненции.
Фармакокинетика
Максимальная концентрация препарата в плазме крови обнаруживается сразу же после введения.
Мельдоний метаболизируется с образованием двух основных метаболитов, которые выводятся почками. Период полувыведения – от 3 до 6 часов.
Показания к применению
Противопоказания
С осторожностью: заболевания почек и/или печени.
Инструкция по применению Идринола: способ и дозировка
Раствор предназначен для внутривенного и парабульбарного (через кожный покров в область нижнего века) введения.
Парабульбарно препарат применяется для лечения офтальмопатологий, в том числе в составе комбинированной терапии: по 50 мг (0,5 мл раствора) в течение 10 дней.
По остальным показаниям Идринол назначают внутривенно. В связи с вероятностью возникновения возбуждающего эффекта вводить раствор рекомендуется в первой половине дня.
Режимы дозирования в зависимости от заболевания:
Побочные действия
Передозировка
В случае превышения рекомендуемой дозы возможно снижение артериального давления, сопровождающееся общей слабостью, головокружением, головной болью и тахикардией. Лечение симптоматическое.
Особые указания
Идринол не является препаратом выбора для лечения острого коронарного синдрома.
Влияние на способность к управлению автотранспортом и сложными механизмами
Сообщения о случаях негативного влияния препарата на психомоторные и когнитивные функции не поступали.
Применение при беременности и лактации
Информация о безопасности применения мельдония во время беременности отсутствует. Во избежание неблагоприятного воздействия препарата на плод его не назначают беременным женщинам.
Выделяется ли мельдоний с грудным молоком, неизвестно. При необходимости проведения лечения во время лактации грудное вскармливание рекомендуется прекратить.
Применение в детском возрасте
Из-за отсутствия данных об эффективности и безопасности применения Идринола в возрасте до 18 лет, препарат не используют для лечения детей и подростков.
При нарушениях функции почек
Препарат следует с осторожностью применять при заболеваниях почек.
При нарушениях функции печени
Препарат следует с осторожностью применять при заболеваниях печени.
Лекарственное взаимодействие
Согласно инструкции, Идринол можно сочетать со следующими лекарственными средствами: бронхолитики, антикоагулянты, диуретики, антиагреганты, антиангинальные и антиаритмические препараты.
Мельдоний усиливает эффект сердечных гликозидов.
Следует соблюдать осторожность при одновременном применении периферических вазодилататоров, гипотензивных средств, нифедипина, нитроглицерина, альфа-адреноблокаторов, поскольку при подобных комбинациях возможно развитие артериальной гипотензии и умеренной тахикардии.
Аналоги
Аналогами Идринола являются: Ангиокардил, Вазомаг, Кардионат, Мидолат, Милдроксин, Мельдоний, Милдронат.
Сроки и условия хранения
Срок годности – 3 года.
Хранить препарат в недоступном для детей месте при температуре до 25 °С. Не допускать замораживания.
Условия отпуска из аптек
Отпускается по рецепту.
Отзывы о Идриноле
Метаболические средства обычно применяются в составе комплексной терапии, при которой состояние больного улучшается в целом, поэтому сделать вывод об эффективности конкретно мельдония несколько сложно. Согласно отзывам о Идриноле от пациентов, получавших его при стенокардии, препарат значительно снижает частоту приступов боли в сердце и аритмии, уменьшает потребность в нитроглицерине. Спортсмены отмечают повышение выносливости физической нагрузки, а лица, перенесшие инсульт – улучшение памяти и зрения.
Также Идринол характеризуется хорошей переносимостью и отсутствием побочных эффектов.
Цена на Идринол в аптеках
Цена на Идринол за 5 ампул в упаковке составляет 149–190 руб., за 10 ампул в упаковке – 284–317 руб.
Идринол: цены в интернет-аптеках
ИДРИНОЛ 100мг/мл 5мл 5 шт. раствор для инъекций ампулы
Идринол 100 мг/мл раствор для внутривенного и парабульбарного введения 5 мл 5 шт.
Идринол р-р д/ин 100мг/мл амп 5мл №5*
Идринол р-р д/ин 100мг/мл амп 5мл №5
Идринол р-р в/в и парабульб. введ. 100мг/мл 5мл n5
Идринол 250 мг капсулы 40 шт.
Идринол капс. 250мг №40
Идринол раствор для инъекций 10% 5 мл 5 амп
ИДРИНОЛ 250мг 40 шт. капсулы
ИДРИНОЛ 100мг/мл 5мл 10 шт. раствор для инъекций ампулы
Идринол капсулы 250 мг n40
Идринол 100 мг/мл раствор для внутривенного и парабульбарного введения 5 мл 10 шт.
Идринол р-р в/в и парабульб. введ. 100мг/мл 5мл n10
Идринол р-р д/ин 100мг/мл амп 5мл №10*
Идринол р-р д/ин 100мг/мл амп 5мл №10
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Образование: Ростовский государственный медицинский университет, специальность «Лечебное дело».
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