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Кровоток в маточных артериях

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17 августа 2019

После оплодотворения яйцеклетки и развития зародыша в матке образуется плацента, связывающая ребенка и мать единой единой системой кровообращения. Через нее плод получает кислород и питательные вещества, необходимые для формирования и роста. Также она используется для выведения ненужных веществ, которые образуются после различных биохимических реакций.

Содержание

Особенности кровообращения между матерью и ребенком при беременности

Нарушение тока крови плаценты вызывает недостаток питания и кислорода у дитя и становится причиной его гибели. Состояние плацентарно-маточного кровотока требует пристального внимания в ходе беременности. Для оценки его состояния проводится плановая диагностика, принимаются профилактические и терапевтические меры.

Работа кровообращения между матерью и малышом основана на функционировании пупочной артерии, вен, плаценты. Маточные артерии способны сокращаться, перекрывая течение крови из-за толщины мышечного слоя, который они имеют. Такое строение маточных артерии предусмотрено для сокращения кровопотери при менструациях.

При беременности на сроке 4-5 недель во время гестации яйцеклетки мышечный слой в артериях исчезает под действием гормонов. На 16 неделе происходит еще одно преобразование артерий, в ходе которого они открываются для постоянного наполнения кровью.

В артериях происходит:

  • соединение двух потоков разного направления;
  • диффузия веществ, необходимых растущему малышу;
  • обогащение плодового кровотока кислородом и полезными веществами, принесенными материнским кровообращением.

Часть работы кровообращения ложится на артерии и вены пуповины. По артериям кровь поступает к малышу, а по вене возвращается в плаценту. Нарушение плодово-плацентарного тока крови ведет к торможению роста органов ребенка, несет угрозу для его здоровья.

Почему может нарушится кровообращение

Причины фетоплацентарной недостаточности (нарушения циркуляции крови между матерью и ребенком):

  1. Низкая плацентация (прикрепление плаценты к стенке нижним отделам матки или «предлежание»). Тонкий мышечный слой нижнего отдела матки не способен обеспечить достаточное поступление крови к плоду. Если не наблюдается миграции плаценты (продвижения в верхней части матки), ситуация угрожает усугублением патологии.
  2. Поздний токсикоз беременных. Он поражает мелкие сосуды матки, что нарушает процессы циркуляции крови.
  3. Падение уровня гемоглобина или анемия. Это состояние вызывает ускоренное сердцебиение у матери, изменяя нормальное кровообращение в маточно-плацентарном круге.
  4. Несовместимость резус-факторов крови матери и малыша, вызывающая анемию у плода и иммунный конфликт.
  5. Высокое артериальное давление у матери из-за проблем с сердцем, образованием отечности, стрессов.
  6. Патология пуповинных артерий, например, наличие только одной пупочной артерии.
  7. Многоплодная беременность, требующая большего количества питательных веществ.

Способствуют распространению патологии некоторые заболевания матери, в частности:

  • Острые инфекции, возбудители которых способны проникать в плаценту;
  • Порок матки («двурогая» матка, имеющая по середине перегородку, делящую ее на две половины). Развитие плода в протекает только в одной из них. Угрозу представляет фактор сдавливания растущего плода и нарушение кровотока, идущего к нему. В таких ситуациях нередко возникает нарушение маточно-плацентарного кровотока слева 1а степени или справа.
  • Сахарный диабет. Он поражает стенки сосудов матки.
  • Отклонения маточного эпителия (эндометриоз).
  • Маточные опухоли. Размер доброкачественной опухоли (миомы) определяет насколько плод будет страдать от недостаточности кровоснабжения. Чем больше миома, тем выше риск недостаточности. Изменения гормонального фона, спровоцированные беременностью, стимулируют рост новообразований. Наличие этого заболевания требует постоянного контроля маточного кровоснабжения.

Возможные последствия

Серьезные отклонения плацентарного кровотока ведут к порокам развития плода и смертности. Недостаточность кровообращения делится на несколько стадий. Наибольшую опасность представляют отклонения второй и третьей степени.

Ответом на вопрос, опасно ли это, служат статистические данные перинатальной смертности, согласно с которыми патологии кровотока 2 степени — причина гибели 13% младенцев в возрасте старше 22 недель. Третья стадия вызывает гибель в 48% случаях. Сократить эти показатели помогает своевременная терапия и экстренное родоразрешение путем кесарева сечения.

Развитие ребенка в условиях плацентарной недостаточности отражается на его физическом и психическом состоянии в постнатальном периоде.

В чем опасность для будущего ребенка

Главная опасность плацентарной недостаточности для растущей крохи — гипоксия.

Последствия недостатка кислорода:

  • недостаток массы малыша (задержка внутриутробного развития);
  • нарушение процесса образования внутренних органов;
  • сбой в кислотно-щелочном балансе и составе электролитов;
  • развитие гормонального дисбаланса и сбой в гормональной системе;
  • отсутствие «жировых депо».

Тяжелое отклонение плацентарного кровотока и дисфункция плаценты угрожают малышу гибелью, влекут прерывание беременности.

Степени нарушенного кровотока

Существует три стадии отклонения циркуляции крови между малышом и мамой от нормы:

I — изменения на этой стадии не несут серьезной угрозы для дитя и компенсированы, то есть наблюдается отклонение артериального кровотока при сохраненном токе крове в сосудах пуповины и наоборот. Ребенок развивается нормально. Стадия делится на два вида изменений, имеющих свой код:

1а степень — проблемы затрагивают только одну артерию, показатели развития малыша в норме.

1в степень — отклонение кровотока от нормы отмечается в сосудах пуповины. Тип гиподинамии, при котором артерии матки работают в обычном режиме. В этом русле отмечается нормальное количество крови.

Если незначительные проблемы в снабжении плода питанием и кислородом не выявлены вовремя и не получили необходимой терапии, через месяц у беременной могут развиться отклонения плацентарно-маточной гемодинамики второй степени.

II — ухудшение тока крови затрагивает пуповинные и маточные артерии.

III — критическое ухудшение циркуляции крови в маточно-плацентарном круге, риск обратного тока крови в артериях, плацентарного кровотечения.

Такая классификация отклонений гемодинамики при беременности, установленная МКБ, позволяет точно оценить состояние кровотока и составит прогноз на лечение и предстоящее родоразрешение.

Методы диагностики

Для выявления нарушения обменных процессов между дитем и матерью используется несколько видов диагностики, направленных на определение характера проблем и их степени.

К диагностическим методам относятся:

  • анализ крови на уровень хорионического гонадотропина, эстрогена и прогестерона;
  • ультразвуковое исследование;
  • кардиотокография (КТГ);
  • допплерометрия.

Наиболее точно поставить диагноз и установить степень нарушений позволяет допплерография. Этот метод фиксирует даже небольшие отклонения от нормы и полностью безопасен для беременной женщины и ее дитя. Результаты допплерографии позволяют специалистам прогнозировать дальнейшее течение вынашивания плода, выбрать необходимую терапевтическую тактику. На экране аппарата можно увидеть графическое цветное изображение кровотоков.

УЗ-диагностика позволяет определить соответствие размеров крохи и развития органов его возрасту. Планово в процессе вынашивания она проводится трижды на сроке 12, 20 и 32 недели. Этот метод позволят без вреда для дитя и матери оценить соответствие его копчиково-теменного размера сроку беременности, а также развитие его внутренних органов, плацентарную гемодинамику.

Кардиотокография позволяет прослушать сердцебиение ребенка, оценить частоту сердечных сокращений, вариабельность базального уровня частоты. Данные, записываемые прибором, сверяются с таблицей. Согласно с таблицей результатов КТГ присваивается балл. Нормальному развитию малыша соответствует 8-10 баллов кардиотокографии.

Диагностика проводится в плановом порядке, пропускать ее беременным категорически не рекомендуется.

Признаки нарушения может заметить сама беременная женщина, но часто они говорят о серьезной стадии патологии. Насторожить будущую маму может снижение или нарастание активности движений малыша. На осмотре у акушера-гинеколога врач отмечает учащенное сердцебиение плода. Тревожный признак несоответствие размера живота фактическому сроку беременности (кроме случаев обусловленных строением тела женщины).

Лечение нарушений

Тактика лечения определяется степенью патологии, установленной с помощью диагностических методов. Сохранить беременность и нивелировать угрозу для плода можно на стадиях ia — iв. Проблемы плацентарного кровотока 1 б степени поддаются терапии. Угрозы для здоровья и нормального развития крохи нет. Отзывы о результатах терапии этой патологии говорят об улучшении, общей положительной динамике, исключении вероятности перехода ко второй степени.

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Вторая степень отклонения требует постоянного контроля состояния дитя. Терапия на ней считается малоэффективной.

Третья стадия дисфункции требует срочного оперативного родоразрешения.

Терапия патологии нацелена на поддержание давления в сосудах, нормализацию кровотока, снижение тонуса матки, стабилизацию психоэмоционального состояния матери, нормализацию работы сердечно-сосудистой системы.

Медикаментозная терапия:

  1. Улучшить кровоток помогают препараты, синтезированные из крахмалов, способные удерживать в сосудах жидкость. К ним относятся Инфукол, Стабизол.
  2. Актовегин и Пентоксифиллин улучшают процессы микроциркуляции.
  3. Лекарства, снимающие спазм (Нош-Па) сосудов, устраняют гипертонус матки, облегчая процессы микроциркуляции.
  4. Для уменьшения степени гипоксии женщины принимают Манге В6, сернокислая магнезия.
  5. Устранить последствия кислородной недостаточности для малыша помогают витамин Е, Токоферол. Они помогаю вывести продукты распада после гипоксии, улучшить состояние крохи.
  6. Если причиной патологии является миома матки назначается Курантил, снижающий вероятность образования тромбов и положительно влияющий на гемодинамику.
  7. Для восстановления тканевого дыхания используется Кокарбоксилаза.

Курс лечения проводится дважды. Первая терапия назначается в момент обнаружения патологии, последующая на сроке тридцать две — тридцать четыре недели. Если расстройство гемодинамики носит серьезный характер, на этом сроке акушер-гинеколог определяет время и способ родоразрешения. Естественные роды показаны беременной только при проблемах с гемодинамикой первой степени. В остальных случаях рекомендовано экстренное или плановое родоразрешение путем кесарева сечения в зависимости от тяжести отклонений.

Если выявлена 2-3 стадия патологии консервативная медикаментозная терапия не проводится. Осуществляется хирургическое лечение путем родоразрешения. В возрасте плода до 32 недель специалисты оценивают его жизнеспособность и состояние. Новорожденный ребенок помещается в кювез, где неонатологи и другие специалисты контролируют его состояние и дальнейшее развитие.

Все решения о том, как улучшить гемодинамику с помощью медицинских препаратов принимает врач. Самостоятельный бесконтрольный прием препаратов грозит дальнейшим развитием патологии и прерыванием беременности.

Что делать для предупреждения патологии — профилактические меры

Лучшая профилактическая мера патологии гемодинамики между организмом матери и развивающимся ребенком — соблюдение принципов здорового образа жизни. От вредных привычек, которые были у женщины до зачатия, необходимо полностью отказаться.

Важный фактор в здоровом развитии крохи — правильное сбалансированное питание матери, употребление продуктов, богатых витаминами и минералами, а также микроэлементами, улучающими работу сердечно-сосудистой системы.

Беременной женщине нужно следить за количеством употребляемой ею жидкости, а также внимательно относится к состоянию своего здоровья, следить за тем, чтобы не было отеков конечностей,гестоза.

Выполнение простых гимнастических упражнений поможет поддерживать хорошее самочувствие и оптимальную работу всех систем организма будущей мамы.

Имеет значение в предотвращении патологии то, с какой скорость в процессе беременности идет прибавка в весе у женщины. Она должна соответствовать изначальному весу женщины до зачатия, строению ее тела и сроку беременности. Превышать показатели нормы не желательно.

Важнее всех профилактических мер считается своевременная постановка на учет, проведение всех плановых диагностических методик исследования для обнаружения отклонений в кровоснабжении малыша, а также вовремя скорректированная тактика наблюдения беременности и родоразрешения.

Заключение

Состояние кровотока в плаценте и пуповине во время вынашивания плода подлежит обязательном контролю со стороны наблюдающего беременность акушера-гинеколога.

Будущая молодая мама обязана чутко относиться к любым изменениям своего состояния и двигательной активности малыша, не игнорировать плановую диагностику и придерживаться назначенной специалистом тактики лечения, если у нее выявлена стадия 1б проблемы с плацентарным кровоснабжением. Большое значение в разрешении ситуации играет положительный настрой мамы и соблюдение ее принципов здорового образа жизни.

Энциклопедия УЗИ и МРТ

Во время вынашивания ребёнка в организме женщины формируются уникальные взаимоотношения «беременная-плацента-плод». Эта новая структура приводит к появлению отдельной и очень важной системы кровоснабжения. Допплерометрия маточно-плацентарного кровотока необходима для оценки параметров гемодинамики и позволяет, на основании этого, выявить патологию или предположить о возможности ее возникновения.

Суть исследования

Допплерометрия (ДПМ) позволяет в ходе ультразвуковой диагностики оценить показатели движения крови в любом интересующем сосуде. В основу метода положен эффект Допплера, который заключается в формировании сдвига частот при отражении ультразвука от объектов, которые находятся в движении. В их качестве выступают клетки крови, движущиеся по сосудистому руслу. При беременности особый интерес представляет УЗИ ДПМ маточно-плацентарного кровотока. Диагностика основывается на оценке характера тока крови в маточных (левой и правой) и артериях пуповины.

Особенности проведения исследования

Беременной женщине нет различия в применении обычного ультразвукового скрининга и допплерометрической диагностики. Она проводится также трансабдоминально конвексным датчиком при положении беременной лежа на спине или на боку. При полном обследовании длительность диагностики увеличивается.

Оно может проводится и трансвагинально. При этом методе поиск и визуализация интересующих сосудов проще. Но следует учитывать, что получаемые значения могут отличаться от результатов трансабдоминального измерения. Для него указаны табличные нормы и, в случае проведения трансвагинальной допплерометрии, следует ориентироваться на специально разработанные таблицы нормативных параметров.

Показания

УЗИ кровотока при беременности не является обязательным исследованием. Его делают при необходимости и по рекомендации гинеколога.

Причины назначения УЗДГ:

  • Заболевания почек или сердечно-сосудистой системы, анемия у беременной.
  • Сахарный диабет. Данная патология приводит к изменению структуры сосудистой стенки и, как вследствие, нарушению кровотока.
  • Гипертония, а также нестабильное артериальное давление вызывает изменение скоростных значений и объема циркулирующей крови.
  • Системные болезни и каллагенозы.
  • Резус-конфликт между беременной женщиной и ребенком приводит к развитию анемии у плода.
  • Оперированная матка, рубец после кесарево сечения. Прикрепление плаценты в этой области мешает её нормальному функционированию и кровоснабжению.
  • Задержка внутриутробного развития или несоответствие размера плода сроку гестации.
  • Миома матки. Данное образование требует питания и кровоснабжения, что приводит к «обкрадыванию» плацентарного тока.
  • Маловодие или многоводие.
  • Пороки развития плода.
  • Преждевременное созревание или старение плаценты.
  • Удары и травмы живота могут приводить к её отслоению и нарушению кровоснабжения в системе мать-плод.
  • Обвитие пуповиной, патология (два сосуда) требует регулярного контроля кровотока.
  • Срок беременности больше 40 недель.
  • Гестоз приводит к нарушению структуры мелких сосудов и затем усложняется диффузия питательных веществ для плода.

Исследование кровотока в ранние сроки беременности (Ⅰ-Ⅱ триместр) не проводится и не является диагностически важным параметром. До 20 недели происходит формирование плаценты и маточно-плацентарного кровообращения, что делает бессмысленным проведение такой диагностики раньше этого срока.

Противопоказания

Как и обычное УЗИ, допплерометрия не имеет абсолютных ограничений. История применения оба вида диагностики не знают доказанных случаев вредного воздействия на мать и плод. Однако, учитывая тот факт, что использование допплера требует больших мощностей, метод следует ограничить и применять при наличии рекомендаций.

Параметры обследования

В качестве стандартов оценки получаемых результатов выступают следующие показатели:

  • Индекс резистентности (ИР) — рассчитывается по формуле ИР=(С-D)/С, где

С — максимальная скорость в течение систолы

D – скорость к концу диастолы.

  • Пульсационный индекс (ПИ) — рассчитывается по формуле ПИ=(С-D)/M , где

М — среднее значение скорости кровотока.

  • Систоло-диастолическое отношение (СДО) — представляет собой связь максимальной систолической и минимальной в диастолу.

Расчёт параметров и индексов лучше проводить на 3-5 сердечных цикла и затем устанавливать усредненный показатель. Это позволит получить наиболее достоверное и объективное значение. Расчет ИР, ПИ и СДО делают для маточных и артерии пуповины. При расширенной допплерометрии данные параметры оценивают в большем количестве сосудов (средней мозговой артерии, аорте плода и венозном протоке).

Все представленные показатели имеют важное значение. Пульсационный индекс выявляется линейной, а не параболической, как другие параметры, зависимостью от сосудистого сопротивления. Это делает ПИ универсальным и наиболее часто применяемым. Кроме этого, ПИ актуален для оценки кровоснабжения при нулевом и реверсном диастолическом токе.

Нормативные значения в маточных артериях.

Срок беременности, недели Индекс резистентности Систоло-диастолическое отношение Пульсационный индекс
20 0,372-0,703 1,987-1,917 1,03-2,04
21 0,368-0,694 1,985-1,915 0,97-1,98
22 0,365-0,687 1,982-1,914 0,92-1,91
23 0,363-0,684 1,897-1,936 0,85-1,87
24 0,357-0,676 1,895-1,934 0,82-1,78
25 0,355-0,663 1,892-1,835 0,75-1,75
26 0,352-0,653 1,815-1,854 0,72-1,69
27 0,348-0,647 1,813-1,853 0,68-1,66
28 0,348-0,643 1,811-1,851 0,62-1,64
29 0,347-0,636 1,763-1,806 0,55-1,56
30 0,346-0,624 1,762-1,802 0,54-1,54
31 0,346-0,618 1,761-1,812 0,53-1,52
32 0,344-0,614 1,713-1,760 0,51-1,49
33 0,344-0,596 1,725-1,761 0,47-1,47
34 0,341-0,592 1,763-1,755 0,47-1,47
35 0,339-0,586 1,667-1,742 0,45-1,45
36 0,337-0,581 1,664-1,741 0,44-1,45
37 0,334-0,579 1,661-1,721 0,44-1,43
38 0,332-0,577 1,678-1,719 0,41-1,42
39 0,331-0,574 1,676-1,716 0,42-1,41
40 0,326-0,571 1,674-1,714 0,42-1,41
41 0,321-0,565 1,671-1,712 0,41-1,43
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Нормативные значения в пупочной артерии.

Срок беременности, недели ИР СДО ПИ
20 0,632-0,845 3,876-3,958 1,23-1,66
21 0,625-0,832 3,873-3,956 1,17-1,54
22 0,614-0,821 3,871-3,955 1,16-1,53
23 0,606-0,821 3,871-3,952 1,08-1,42
24 0,593-0,814 3,415-3,616 0,97-1,25
25 0,583-0,805 3,411-3,613 0,97-1,34
26 0,584-0,792 3,191-3,273 0,87-1,14
27 0,573-0,791 2,886-2,946 0,87-1,12
28 0,564-0,786 2,885-2,945 0,88-1,22
29 0,551-0,782 2,883-2,944 0,89-1,16
30 0,546-0,775 2,883-2,943 0,75-1,12
31 0,538-0,764 2,881-2,941 0,72-1,08
32 0,526-0,753 2,487-2,526 0,66-1,09
33 0,514-0,747 2,484-2,523 0,58-0,94
34 0,493-0,736 2,482-2,521 0,57-0,92
35 0,482-0,723 2,432-2,456 0,54-1,03
36 0,461-0,716 2,421-2,455 0,52-1,01
37 0,443-0,706 2,414-2,451 0,53-1,02
38 0,431-0,692 2,198-2,225 0,38-1,09
39 0,423-0,681 2,196-2,223 0,36-1,08
40 0,411-0,672 2,193-2,223 0,35-1,07
41 0,406-0,664 2,191-2,221 0,34-1,03

Из-за небольшого диаметра интересующих сосудов, определение скоростных показателей довольно затруднительно. В связи с этим важное значение имеет кривая кровотока. Изображение в маточной артерии в норме (а) и при патологии (б)

стрелка указывает на патологически изменённую картину

Фото в пупочной артерии (на изображении (а) представлен нормальный кровоток, на (б) он же при некорректной настройке аппарата).

динамика в норме на обоих изображениях, несоответствующие настройки аппарата на изображении б (по фильтру частот)

Нарушение маточно-плацентарного кровотока

Для упрощения понимания данной патологии и её степени введена классификация, которая основана на зависимости от уровня сбоя.

  • ⅠА. Обусловлена проблемами в одной маточной артерии. А в остальных сосудах кровоток не изменен.
  • ⅠВ. Вызвана его нарушением в пупочной, на фоне этого изменений в маточных при допплерометрии нет.
  • Ⅱ . Характеризуется сбоями в обеих.
  • Ⅲ . Проблемы выражены значительно, имеется реверсный (обратный) кровоток в маточных и (или) в артериях пуповины.

самая тяжёлая (III) степень нарушения для сосудов пуповины и матки

Правильное выявление степени нарушения кровотока позволяет сделать верный выбор в тактике ведения беременности.

Оценка полученных результатов

Исследование маточных артерий необходимо проводить с двух сторон. В нормальном состоянии существенной разницы в показателях не выявляется. Индекс резистентности с места прикрепления плаценты может быть несколько ниже.

Видео допплерометрии маточных артерий в норме

В процессе роста плода и формирования плаценты требуется усиление кровоснабжения матки и, как следствие, увеличение диаметра маточных артерий и кровотока в 10 раз. Если этого не происходит (на фоне соматической патологии или аномалии), то плод испытывает дефицит кислорода и питательных веществ.

Признаки нарушения кровотока в маточных артериях:

  • снижение диастолической скорости;
  • повышение индекса резистентности;
  • появление дикротической выемки на кривой кровотока.

При расшифровке результатов следует учитывать, что данное нарушение имеет нестабильное течение. Это приводит к тому, что кривая скоростей с разницей в несколько дней между исследованиями может отличаться.

Двустороннее изменение параметров является критерием нарушения маточно-плацентарного кровообращения. Одностороннее же зачастую свидетельствует о развитии гестоза или предрасположенности к нему.

В пуповине находятся две артерии и одна вена. В первых показатели кровотока должны быть идентичны. Критериями нарушения считается превышение СДО, ИР и ПИ больше установленных норм для данного срока беременности. Критическими показателями состояния ребенка является выявление нулевого или реверсного кровотока. Пример диагностики в пупочной артерии на видео.

Артефакты и оптимизация

При проведении допплерометрии и выявлении маточно-плацентарного кровотока исследователь должен быть уверен в точности измерений.

Неверное определение параметров порой обусловлено рядом ошибок, допущенных при диагностике:

  • неправильный выбор области исследования;
  • некорректный угол и контрольный объем при проведении измерений;
  • смещение рассматриваемого сосуда при движении плода.

Для исключения возможности гипердиагностики и упущения патологии необходимо соблюдать ряд правил по оптимизации допплерометрии.

  • Во время проведения измерений беременная женщина должна быть в сположении, перемещения плода минимальными или вовсе отсутствовать. Исследование проводится с учетом дыхательных движений.
  • Цветовое допплеровское картирование помогает в определении направления тока крови в сосудах.
  • Соблюдение максимально острого угла инсонации для уменьшения процента погрешности измерений.
  • Использование предельно возможных значений контрольного объема.
  • Все настройки (периодичность повторения импульсов, частотный фильтр) для каждого пациента должны быть индивидуальны.
  • Измерения же воспроизводимыми, другими словами, одинаковыми при повторном диагностировании.
  • Важно проводить допплерометрию в установленном сегменте: в маточных артериях — перед их разделением на аркуатные, в пупочных — на свободном участке пуповины. В ситуации многоплодной беременности последние проверяют вблизи крепления. При этом параметры сосудистого сопротивления будут иметь завышенные значения, и стандартные таблицы для оценки не подходят.
  • При наличии врожденных аномалий развития половых органов или при многоплодной беременности получаемые значения при допплерометрии отличаются от табличных. Так, например, единственная артерия пуповины будет иметь больший диаметр и показатели сопротивления станут ниже допустимых. В данном случае ключевое значение принадлежит оценке кривых скоростей.

Последствия нарушений маточно-плацентарного кровотока

  • Задержка внутриутробного развития.
  • Низкая масса тела ребенка при рождении.
  • Проблемы в работе сердечно-сосудистой системы (тахи- и брадикардия, аритмия).
  • Изменения гормонального фона.
  • Дисбаланс кислотно-щелочной среды.
  • Угрожающее прерывание беременности.
  • Внутриутробная смерть плода.

Тактика ведения при нарушении МПК

Как и оговаривалось ранее, наблюдение беременной в вышеописанном положении напрямую зависит от уровня.

При сбоях ⅠА степени медикаментозного вмешательства не требуется. Всё сводится к нормализации режима дня и питания женщины. Рекомендуется двигательная активность, прогулки на свежем воздухе, дыхательная гимнастика.

ⅠВ степень требует назначения антигипоксической терапии. К тому же необходим контроль коагулограммы, и при выявлении повышенной свертываемости крови назначаются также кроворазжижающие препараты. Наблюдение за допплерометрией проводят каждые две недели или, по показаниям, чаще.

Ⅱ степень требует стационарного контроля и лечения. За беременной устанавливают круглосуточное наблюдение, проводят антигипоксическую терапию. Допплерометрия делается каждые два дня или ежедневно.

Ⅲ степень является критической и требует скорейшего родоразрешения. Для него используют кесарево сечение, так как естественные роды могут привести к гибели ребенка. При недопустимо малых сроках беременности решения принимаются индивидуально.

Исследование системы кровотока имеет важное значение в своевременном выявлении нарушений питания плода. Оптимально для этого является проведение допплеровского исследования в период второго и третьего скрининга (20-24 и 30-32 недели беременности).

В связи с тем, что цена на допплерометрическое исследование достаточно высока, возможности постоянного контроля кровотока для всех беременных нет. Для этого используют еженедельную запись кардиотокограммы начиная с 30 недели (а в условиях стационарного наблюдения — ежедневная проверка). При наличии явных изменений на КТГ проводят ультразвуковой контроль с оценкой кровообращения в системе «мать-плод».

Беременные женщины и их родные обычно ожидают от УЗИ-обследования одного ответа — каков пол ребенка. Для врача акушера-гинеколога метод исследования необходим, чтобы вовремя выявить нарушение кровотока при беременности, неправильное развитие плода.

От этого зависит план ведения и тактика родоразрешения. Чтобы понять механизмы нарушения, необходимо рассмотреть возможности системы кровообращения между матерью и ребенком.

Структура маточно-плацентарного кровотока

Мать и дитя соединены не только плацентой, но и сложной системой кровеносных сосудов. Поэтому все совместное кровообращение принято делить на уровни, которые не могут существовать изолированно, а работают только в комплексе.

  • Центральным отделом системы считается плацента. Она обеспечивает «всасывание» продуктов из материнской крови через ворсинки, проросшие вглубь стенки матки. При этом не перемешивается кровь матери и ребенка. Несколько рядов специальных клеток образуют гематоплацентарный барьер, являющийся серьезным препятствием для ненужных плоду веществ. Через него отработанная кровь возвращается в венозную систему матери.
  • Вторую часть кровотока составляют ветви маточных артерий. Если до беременности в женском организме они находятся в спавшемся состоянии и называются спиральными, то со срока 1 месяц в них происходит потеря мышечного слоя, способного вызывать спазм. А к четырем месяцам артерии преображаются в полноценные стволы, наполненные кровью и направляющиеся в зону плаценты. Именно этот механизм, полезный для питания плода, может оказаться роковым при маточных кровотечениях: стенки сосудов уже не могут сокращаться.
  • Сосуды в пуповине образуют третий путь кровотока. Здесь проходит 2 артерии и вена. Они связывают ребенка с плацентой и образуют плодово-плацентарный круг. Снижение кровотока на этом уровне наносит наиболее тяжелые поражения плоду.
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Как нарушается плацентарное кровообращение

Плохой кровоток, связанный с плацентой, называют плацентарной недостаточностью. Она может возникнуть на любом сроке беременности в двух формах.

Острая появляется внезапно, даже в родах, не зависит от срока беременности. Плод впадает в состояние гипоксии (кислородной недостаточности), что угрожает ему гибелью.

Основные патологические механизмы этого состояния:

  • преждевременная отслойка плаценты;
  • инфаркт в связи с тромбообразованием.

Хроническая чаще осложняет течение беременности после 13-недельного срока. Симптомы проявляются в третьем триместре. Механизм формирования — раннее старение плаценты из-за отложения фибрина на ворсинах.

Негативные последствия в таких условиях в зависимости от степени нарушения могут привести к неминуемой гибели плода.

Причины нарушения кровотока при беременности

Вызвать нарушение маточно-плацентарного кровотока могут различные причины. К ним относятся общие заболевания матери:

  • патология нейроэндокринной системы (сахарный диабет, болезни щитовидной железы и надпочечников, изменения в области гипоталамуса ствола мозга);
  • заболевания легких (эмфизема, бронхиальная астма);
  • нарушения в сердечно-сосудистой системе, вызванные пороками развития, последствиями гипертензии, склонностью к гипотонии;
  • почечная патология (хронический нефрит, пиелонефрит, особенно в стадии почечной недостаточности;
  • малокровие (анемии), связанные с дефицитом железа, витаминов;
  • состояния, сопровождающиеся повышенной свертываемостью крови, способствуют повышенному тромбообразованию в сосудах плаценты;
  • острые и обострение хронических инфекционных процессов —вызывают соответствующее воспаление в плаценте, отек сосудов и сокращение кровотока, в первом триместре это может закончиться выкидышем.

Патология матки создает локальные условия для неполноценного кровотока:

  • любые изменения слоев матки (миометрия, эндометрия);
  • пороки развития (например, по типу «двурогой», «седловидной» матки);
  • недоразвитие (гипоплазия);
  • опухолевые образования из мышечной ткани (миомы), особенно у первородящей женщины в возрасте старше 35 лет, в более молодом возрасте небольшие миомы позволяют компенсировать кровоток.

К причинам недостаточного кровотока относятся неблагоприятные условия протекающей беременности в случаях:

  • многоплодия;
  • резус-конфликта;
  • гестоза;
  • тазового предлежания плода;
  • патологического предлежания плаценты.

Риск возникновения нарушенного кровотока возникает при:

  • предшествующих абортах;
  • курении, алкоголизме и наркомании матери;
  • постоянной нервозной обстановке, связанной с социальной или бытовой неустроенностью;
  • нарушением правильного питания женщины.

Виды хронической плацентарной недостаточности

В зависимости от развития последствий для плода и способностей организма матери к приспособлению различают 4 формы или стадии хронической плацентарной недостаточности:

  • компенсации — материнский организм вполне защищает плод улучшением кровотока по другим путям, и ребенок не ощущает недостатка в кислороде, развивается нормально, рождается в срок и хорошо развивается;
  • субкомпенсации — мать не в состоянии полностью компенсировать недостаток питания, и плод отстает в развитии, появляется риск осложнений, врожденных пороков;
  • декомпенсации — сопровождается полным нарушением механизмов приспособления, нормальная беременность невозможна, у плода возникают серьезные пороки, несовместимые с жизнеспособностью, очень вероятна гибель во внутриутробном состоянии;
  • критическая — из-за тяжелых изменений в строении плаценты дальнейшее вынашивание плода невозможно, происходит неизбежная гибель, любое лечение неэффективно.

Какие степени нарушения кровотока вызывает плацентарная недостаточность?

Сопоставление клинических проявлений и результатов УЗИ-обследования позволило выделить 3 степени нарушения кровотока между матерью и плодом.

Первая характеризуется минимальными изменениями на маточно-плацентарном уровне, предоставляет «запас» времени около месяца для лечения и полного восстановления без последствий, выделяют 2 разновидности:

  • Iа — снижен только маточно-плацентарный кровоток, при неизмененном плодово-плацентарном. Проявляется отставанием в развитии плода в 90% случаев.
  • Iб — страдает плодово-плацентарное кровообращение, а маточно-плацентарное остается в норме. Задержка формирования и развития плода страдает несколько меньше (в 80% случаев).

Вторая — нарушение происходит как на уровне маточных, так и в пуповинных сосудах, гипоксия может стать гибельной для плода.

Третья — показатели кровообращения находятся на критическом уровне, даже возможно обратное направление кровотока (реверсное).

Для врачей-клиницистов подобная классификация представляет возможность точно определить уровень нарушений, выбрать наиболее приемлемую тактику лечения.

Симптомы нарушения кровотока

Если нарушенный кровоток компенсируется, то женщина не ощущает никаких отклонений, а узнает о них только после обследования.

Выраженные проявления возникают при острой форме и хронической декомпенсации:

  • двигательная активность плода резко возрастает или совершенно исчезает (при сроке в 28 недель нормальное развитие сопровождается десятью шевелениями за сутки), этот симптом требует немедленного обращения к акушеру-гинекологу;
  • медленное увеличение окружности живота, выявляемое при ежемесячном осмотре и измерении в женской консультации (связан с излишним образованием или недостатком околоплодных вод);
  • поздний токсикоз;
  • повышенное артериальное давление;
  • большая прибавка в весе;
  • отеки на голенях;
  • появление белка в моче.

Диагностика

Наиболее полноценную картину кровообращения между маткой и плодом получают при допплерографическом исследовании, которое проводится всем женщинам трижды за срок беременности.

  • измерить кровоток по скорости движения форменных элементов;
  • определить его направление в артериях и венах;
  • зафиксировать изменения до клинических проявлений.

Все изменения регистрируются на мониторе, замеряются специальными датчиками, могут фотографироваться в необходимом формате.

Путем сравнения с нормальными показателями делается вывод о степени патологии. Нарушения могут быть выявлены на любом уровне, в сосудах:

Врач имеет время назначить лечение и проверить его при следующем обследовании.

Разновидностью допплерографии является допплерометрия. Она назначается при:

  • сопутствующей патологии матери;
  • подозрении на преждевременное старение и нарушение плацентарного барьера;
  • признаки много- или маловодия;
  • предварительных данных о внутриутробной задержке развития, формировании врожденных пороков плода;
  • наличии генетических заболеваний в семье;
  • клинических симптомах гипоксии плода.

При обследовании можно выявить:

  • истончение плаценты;
  • увеличение площади разрастания;
  • внутриутробное инфицирование.

Лечение патологии

Возможность сохранить беременность с помощью консервативного лечения остается при степени нарушенного кровотока Iа и б. Вторая степень считается пограничной, третья — требует срочного оперативного родоразрешения.

Лечение учитывает патогенез нарушений. Чтобы добиться результатов необходимо воздействовать на все звенья:

  • При легком нарушении микроциркуляции назначается Хофитол (с минерально-растительным составом), в более выраженных случаях — Актовегин, Петоксифилин.
  • Если выявляется склонность матери к тромбообразованию и нарушению агрегационных свойств крови, то показаны такие препараты, как Курантил, Трентал. Они способны улучшить проходимость крови по сосудам.
  • При обнаружении пониженного артериального давления используют Венофундин, Стабизол, РеоХЕС.
  • Сосудорасширяющие средства – Но-шпа, Эуфиллин в инъекциях –устраняют спастическое сокращение сосудов.
  • Рекомендуется снизить тонус матки с помощью Магнезии, препарата Магне В6, это действует как антигипоксический способ улучшения кровотока.
  • Группа витаминов с антиоксидантным действием устраняет негативные последствия (витамин Е, аскорбиновая кислота).

Лечебные препараты назначаются врачом. Женщине при необходимости предлагают госпитализацию. Это позволяет:

  • обеспечить постельный режим;
  • постоянно наблюдать течение беременности.

Что делать для предупреждения нарушений кровотока?

Гинекологи призывают женщин из групп риска заранее готовить себя к беременности, не допускать внеплановое зачатие.

На фоне уже возникшей беременности рекомендуется:

  • избегать эмоциональных и физических перегрузок;
  • исключить вредные привычки;
  • организовать для беременной полноценное питание;
  • следить за ежедневными прогулками, пребыванием в проветренном помещении;
  • заниматься специальной гимнастикой для беременных, упражнениями из йоги;
  • контролировать массу тела, проводить ежемесячное взвешивание и измерение окружности живота;
  • считается более полезным сон на левом боку, это положение позволяет снизить давление на нижнюю полую вену, которая проходит справа от матки, но в некоторых случаях при застое в почках сон на правом боку улучшает отток от этих важных органов.

Современные методы диагностики и подхода к ведению беременных позволяют предупредить тяжелые степени нарушений. Однако немало возможностей зависит от самой женщины и ее желания иметь здорового наследника.

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