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Хецикло п инструкция по применению

СОДЕРЖАНИЕ
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17 августа 2019
  • Способ применения
  • Побочные действия
  • Противопоказания
  • Беременность
  • Взаимодействие с другими лекарственными средствами
  • Передозировка
  • Условия хранения
  • Форма выпуска
  • Состав
  • Дополнительно

Аскофен-П — комбинированный препарат, действие которого определяется компонентами, входящими в его состав.
Ацетилсалициловая кислота оказывает обезболивающее, жаропонижающее, противовоспалительное действие, связанное с подавлением циклооксигеназ 1 и 2, регулирующих синтез простагландинов; тормозит агрегацию тромбоцитов.
Кофеин повышает рефлекторную возбудимость спинного мозга, возбуждает дыхательный и сосудодвигательный центры, расширяет кровеносные сосуды скелетных мышц, головного мозга, сердца, почек, снижает агрегацию тромбоцитов; уменьшает сонливость, чувство усталости, повышает умственную и физическую работоспособность.
Парацетамол оказывает жаропонижающее, обезболивающее действие.

Показаниия к применению:
Аскофен-П применяется у взрослых при умеренно или слабо выраженном болевом синдроме (головная, зубная боль, невралгия, миалгия, грудной корешковый синдром, люмбаго, артралгия, альгодисменорея, мигрень), у взрослых и детей старше 15 лет для снижения повышенной температуры тела, при «простудных» и других инфекционно-воспалительных заболеваниях.

Содержание

Способ применения

Препарат Аскофен-П применяют внутрь после еды по 1-2 таблетки 2-3 раза в день. Максимальная суточная доза — 6 таблеток. Перерыв между приемами препарата должен быть не менее 4 часов. Для уменьшения раздражающего действия на желудочно-кишечный тракт препарат следует принимать после еды, запивая водой, молоком, щелочной минеральной водой.
При нарушении функции почек или печени перерыв между приемами — не менее 6 часов.
Препарат не следует принимать более чем 5 дней при назначении в качестве обезболивающего средства и более 3 дней в качестве жаропонижающего. Другие дозировки и схемы применения устанавливает врач.

Побочные действия

Анорексия, тошнота, рвота, гастралгия, диарея, эрозивно-язвенные поражения желудочно-кишечного тракта, желудочно-кишечные кровотечения, печеночная и/или почечная недостаточность, повышение артериального давления, тахикардия.
Аллергические реакции: кожная сыпь, отек Квинке, бронхоспазм.
При длительном приеме — головокружение, головная боль, нарушения зрения, шум в ушах, снижение агрегации тромбоцитов, гипокоагуляция, геморрагический синдром (носовое кровотечение, кровоточивость десен, пурпура и др.), поражение почек с папиллярным некрозом; глухота; синдром Стивенса-Джонсона, токсический эпидермальный некролиз (синдром Лайелла), синдром Рейя у детей (метаболический ацидоз нарушения со стороны нервной системы и психики, рвота, нарушения функции печени).

Противопоказания

Противопоказаниями к применению препарата Аскофен-П являются:
• повышенная чувствительность к ацетилсалициловой кислоте или другим нестероидным противовоспалительным препаратам (НПВП) или ксантинам; повышенная чувствительность к другим компонентам препарата;
• эрозивно-язвенные поражения желудочно-кишечного тракта (в фазе обострения), желудочно-кишечное кровотечение;
• выраженные нарушения функции печени или почек;
• астма, индуцированная приемом ацетилсалициловой кислоты, салицилатов и других нестероидных противовоспалительных средств;
• геморрагические диатезы (болезнь Виллебранда, гемофилии, телеангиоэктазии, гипопротромбинемия, тромбоцитопения, тромбоцитопеническая пурпура);
• расслаивающаяся аневризма аорты;
• дефицит глюкозо-6-фосфатдегидрогеназы;
• портальная гипертензия, дефицит витамина К;
• повышенная возбудимость, нарушение сна, тревожные расстройства (агорафобия, панические расстройства);
• органические заболевания сердечно-сосудистой системы (острый инфаркт миокарда, тяжелое течение ишемической болезни сердца, артериальная гипертензия), пароксизмальная тахикардия, частая желудочковая экстрасистолия;
• глаукома;
• хирургические вмешательства, сопровождающиеся кровотечением;
• дети до 15 лет.
С осторожностью – гиперурикемия, уратный нефролитиаз, подагра, язвенная болезнь желудка и/или двенадцатиперстной кишки (в анамнезе), сердечная недостаточность тяжелой степени.

Беременность

Противопоказано применение препарата Аскофен-П при беременности в I и III триместре, во втором триместре беременности возможен разовый прием препарата в рекомендуемых дозах только в том случае, если ожидаемая польза для матери не будет превышать потенциальный риск для плода.
При необходимости применения препарата в период лактации следует прекратить грудное вскармливание.

Взаимодействие с другими лекарственными средствами

Уменьшает эффективность спиронолактона, фуросемида, гипотензивных препаратов, противоподагрических средств, способствующих выведению мочевой кислоты.
Усиливает побочные действия глюкокортикостероидов, производных сульфонилмочевины, метотрексата, ненаркотических анальгетиков и нестероидных противовоспалительных препаратов.
Следует избегать комбинации препарата с барбитуратами, противоэпилептическими средствами, зидовудином, рифампицином и алкогольсодержащими напитками (увеличивает риск гепатотоксического эффекта).
Под воздействием парацетамола время выведения хлорамфеникола увеличивается в 5 раз. Кофеин ускоряет всасывание эрготамина.
Салициламид, и др. стимуляторы микросомального окисления способствуют образованию токсичных метаболитов парацетамола, влияющих на функцию печени. Метоклопрамид ускоряет всасывание парацетамола. При повторном приеме парацетамол может усилить действие антикоагулянтов (производных дикумарина).

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Передозировка

Симптомы передозировки препарата Аскофен-П: тошнота, рвота, боли в желудке, потливость, бледность кожных покровов, тахикардия.
При легких интоксикациях — звон в ушах; тяжелая интоксикация – сонливость, коллапс, судороги, бронхоспазм, затрудненное дыхание, анурия, кровотечение. По мере усиления интоксикации — прогрессирующий паралич дыхания и разобщение окислительного фосфорилирования, вызывающее респираторный ацидоз. При подозрении на отравление необходимо немедленно обратиться за врачебной помощью.
Лечение: пострадавшему следует сделать промывание желудка и назначить адсорбенты (активированный уголь).

Условия хранения

При температуре не выше 25 оС, в сухом, защищенном от света месте.
Хранить в недоступном для детей месте.

Форма выпуска

Аскофен-П — таблетки.
10 таблеток в контурной безъячейковой или ячейковой упаковке.
1, 2 или 3 контурные ячейковые упаковки с инструкцией по применению в пачке из картона. Контурные ячейковые или безъячейковые упаковки с равным количеством инструкций по применению в групповой упаковке.

Состав

1 таблетка Аскофен-П содержит активные вещества: ацетилсалициловая кислота 200 мг, парацетамол 200 мг, кофеин 40 мг.
Вспомогательные вещества: крахмал картофельный, повидон (поливинилпирролидон низкомолекулярный медицинский), стеариновая кислота, тальк, кальция стеарат, силиконовая эмульсия КЭ-10-12, вазелиновое масло ВГМ-30М.

Описание актуально на 10.07.2014

  • Латинское название: Ascophenum-P
  • Код АТХ: N02BA71
  • Действующее вещество: Ацетилсалициловая кислота + Кофеин + Парацетамол (Acetylsalicylic ac >

Состав Аскофен-П

Каждая таблетка включает с состав активные компоненты: парацетамол 200 мг, ацетилсалициловую кислоту 200 мг, кофеин 40 мг.

Вспомогательные вещества: стеариновую кислоту, повидон, крахмал картофельный, тальк, кальция стеарат, силиконовую эмульсию и вазелиновое масло.

Форма выпуска

Выпускается Аскофен-П в виде таблеток светлого оттенка, плоскоцилиндрической формы без особого запаха. В аптеках лекарство реализуется в упаковках по 10 штук.

Фармакологическое действие

Препарат обладает комбинированным действием, объединяющим нестероидный противовоспалительный, анальгезирующий ненаркотический и психостимулирующий эффект.

Фармакодинамика и фармакокинетика

Комбинированный препарат, эффективность которого обеспечивают составляющие его компоненты.

Ацетилсалициловая кислота оказывает заметное обезболивающее, жаропонижающее и противовоспалительное действие, затормаживает агрегацию тромбоцитов.

Парацетамол также проявляет жаропонижающий и обезболивающий эффект.

Кофеин способствует повышению рефлекторной возбудимости спинного мозга, возбуждению дыхательной и сосудодвигательной функций, расширению кровеносных сосудов, мышц, сердца, головного мозга, почек, снижению агрегации тромбоцитов. Кроме того, приём кофеина помогает снизить сонливость и усталости, повысить работоспособность и так далее.

В результате приёма внутрь всасывается почти 90% препарата. При этом максимальная концентрация веществ в сыворотке достигается в разное время: парацетамола – в течение часа, кофеина – 2,5 ч, ацетилсалициловой кислоты – 1-2 ч.

Из организма почти 80% кислоты активных веществ выводится при помощи почек.

Показания к применению Аскофен-П

  • болевой синдром средней степени различной этиологии, например: головная или зубная боль,мигрени, невралгия, миалгия, артралгия и так далее;
  • лихорадочные состояния, вызванные простудными и ревматическими болезнями.

Аскофен-П при беременности

Следует заметить, что данный препарат не рекомендуется к приёму при беременности, особенно в I и III триместре. Допускается разовое применение лекарства во 2-м триместре беременности, но если точно установлено, что это не причинит вред плоду.

Как известно, приём препарата в I триместре может вызвать порок развития плода в виде расщепления верхнего нёба, вызванное тератогенным влиянием ацетилсалициловой кислоты.

В III триместре – сохраняется вероятность торможения родовой деятельности, закрытие артериального протока у будущего малыша, вызывающее гиперплазию сосудов в лёгких и гипертензию в сосудах кровообращения.

Противопоказания к применению

  • непереносимость препарата или его составляющих;
  • различные поражения ЖКТ;
  • нарушения в работе печени или почек;
  • отклонения в деятельности дыхательной системы, например, при астме;
  • расслаивающаяся аневризма аорты;
  • некоторые расстройства нервной и сердечно-сосудистой системы;
  • возраст менее 15 лет;
  • лактация, беременность и так далее.

Побочные эффекты

При лечении данным препаратом могут возникать разнообразные проблемы в деятельности ЖКТ в виде: анорексии, тошноты, рвоты, гастралгии, диареи, эрозивно-язвенных повреждений, кровотечений. Также не исключено развитие: печеночной или почечной недостаточности, тахикардии и повышение артериального давления.

Длительный приём лекарства вызывает: головокружение, шум в ушах, головную боль, гипокоагуляцию, разнообразные нежелательные синдромы и нарушения деятельности печени.

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Таблетки Аскофен, инструкция по применению (Способ и дозировка)

Как указывает инструкция по применению Аскофен-П, данные таблетки назначают для приёма после еды 2-3 раза в сутки в количестве 1-2 штуки. При этом максимальное суточное дозирование не должно превышать 6 штук, а перерыв быть меньше 4 часов.

Учитывая показания к применению Аскофена, нужно соблюдать некоторые особенности приёма:

  • запивать таблетки лучше молоком, обычной тёплой или минеральной водой;
  • пациентам с нарушениями функций почек или печени нужно увеличить перерыв между приёмом лекарства – от 6 часов.

Кроме этого, курс обезболивающей терапии не должен превышать 5 дней и лечение жара – больше 3 дней. В других случаях длительность лечения и дозировка определяется врачом.

Передозировка

При передозировке может проявиться:

  • тошнота, рвота, болевые ощущения в ЖКТ;
  • потливость, бледность кожи;
  • тахикардия;
  • звон в ушах;
  • сонливость, коллапс, судорожное состояние;
  • бронхоспазм, проблемы с дыханием и так далее.

Если возникает подозрение на отравление, то нужно срочно вызвать врачебную помощь. Обычно пострадавшему промывают желудок и назначают адсорбенты.

Взаимодействие

Одновременное лечение с Аскофен-П приводит к усилению действия гепарина, резерпина, непрямых антикоагулянтов, стероидных гормонов и некоторых гипогликемических средств. Также вероятно понижение эффективности фуросемида, спиронолактона, гипотензивных и противоподагрических препаратов, которые помогают выводить мочевую кислоту из организма.

Отмечено усиление побочных действий глюкокортикостероидов, метотрексата, производных сульфонилмочевины, а также нестероидных противовоспалительных средств и ненаркотических анальгетиков.

Не рекомендуется комбинировать данное лекарство с барбитуратами, противоэпилептическими препаратами, зидовудином, рифампицином и спиртосодержащими напитками, потому что сохраняется вероятность развития гепатотоксического эффекта.

Влияние парацетамола увеличивает период выведения хлорамфеникола почти в 5 раз. Что касается кофеина, то он способствует ускорению всасывания эрготамина.

Комбинированная терапия с Салициламидом и прочими стимуляторами микросомального окисления способствуют выработке токсичных метаболитов парацетамола, негативно влияющих на функции печени.

Одновременный приём с Метоклопрамидом усиливает всасывание парацетамола. Повторное применение способно повысить эффект антикоагулянтов.

Особые указания

Продолжительное лечение данным препаратом требует контроля периферической крови и функций печени.

Ацетилсалициловая кислота обладает антиагрегатным действием, по этой причине пациенты перед проведением хирургического вмешательства должны сразу предупреждать врачей о том, что они принимают этот препарат. Низкие дозировки ацетилсалициловой кислоты сокращают выведение мочевой кислоты, что нередко провоцирует приступ подагры.

Условия продажи

Данные таблетки отпускают без рецепта.

Условия хранения

Лекарство нужно хранить в достаточно сухом и тёмном месте при температуре до 25 °С.

Срок годности

Препарат годен 2 года.

Аналоги

Подобным действием также обладают препараты: Орафен, Флексен, Дикловит, Артрозилен, Бофен и другие.

Алкоголь и Аскофен-П

При лечении данным препаратом запрещено употребление любых алкогольсодержащих напитков, так как они повышают риск развития кровотечений в ЖКТ.

Отзывы об Аскофен-П

Как показывают многочисленные отзывы пациентов, оставленные на различных форумах, данный препарат является отличным, недорогим и действенным комбинированным средством. Многие пользователи давно принимают таблетки Аскофен, от чего лечебный эффект не становится ниже, так как они пользуются ими периодически.

При этом некоторые пациенты спрашивают, от чего Аскофен-П помогает лучше всего и как часто можно его использовать? На это специалисты отвечают, что таблетки обладают равноценным обезболивающим, жаропонижающим и противовоспалительным действием. Однако когда эти нежелательные симптомы быстро не устраняются, то нужно обратиться к врачу.

Кроме того, существует немало особенностей и противопоказаний к приёму данного лекарства. Например, Аскофен Дарница способен больше других форм обострить проявление астмы, вызывая развитие сильнейших аллергических реакций.

Аскофен повышает или понижает давление?

Данный препарат нередко принимают люди, страдающие артериальной гипотонией, то есть пониженным давлением, с целью избавления от данного недуга. При этом они утверждают, что подобное лечение было им рекомендовано врачом. Большинство пациентов довольны производимым эффектом.

Конечно, данная комбинация веществ включает малую дозировку кофеина, не способную оказывать стимулирующего влияния на ЦНС, но нормализующую тонус сосудов мозга и ускоряющую кровоток. Поэтому пациентам с повышенным давлением нужно с осторожностью принимать эти таблетки, а людям с пониженным давлением всё же не злоупотреблять подобной терапией.

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Цена Аскофен-П, где купить

Данное лекарство доступно практически всем пациентам, так как в российских аптеках его цена составляет от 14 руб.

Почему жадные аптеки скрывали средство мощнее Экзодерила в 39 раз? Им оказался советский густой.

Инструкция по применению

Международное наименование

Групповая принадлежность

Описание действующего вещества (МНН)

Лекарственная форма

Фармакологическое действие

Комбинированный препарат. АСК обладает жаропонижающим и противовоспалительным действием, ослабляет боль, особенно вызванную воспалительным процессом, а также умеренно угнетает агрегацию тромбоцитов и тромбообразование, улучшает микроциркуляцию в очаге воспаления.

Кофеин повышает рефлекторную возбудимость спинного мозга, возбуждает дыхательный и сосудодвигательный центры, расширяет кровеносные сосуды скелетных мышц, головного мозга, сердца, почек, снижает агрегацию тромбоцитов; уменьшает сонливость, чувство усталости, повышает умственную и физическую работоспособность. В данной комбинации кофеин в малой дозе практически не оказывает стимулирующего действия на ЦНС, однако способствует нормализации тонуса сосудов мозга и ускорению кровотока.

Парацетамол обладает анальгетическим, жаропонижающим и крайне слабым противовоспалительным действием, что связано с его влиянием на центр терморегуляции в гипоталамусе и слабовыраженной способностью ингибировать синтез Pg в периферических тканях.

Показания

Противопоказания

Побочные действия

Гастралгия, тошнота, рвота, гепатотоксичность, нефротоксичность, эрозивно-язвенные поражения ЖКТ, аллергические реакции, тахикардия, повышение АД, бронхоспазм.

При длительном применении – головокружение, головная боль, нарушения зрения, шум в ушах, снижение агрегации тромбоцитов, гипокоагуляция, геморрагический синдром (носовое кровотечение, кровоточивость десен, пурпура и др.), поражение почек с папиллярным некрозом; глухота; злокачественная экссудативная эритема (синдром Стивенса-Джонсона), токсический эпидермальный некролиз (синдром Лайелла), синдром Рейе у детей (гиперпирексия, метаболический ацидоз, нарушения со стороны нервной системы и психики, рвота, нарушения функции печени).

Применение и дозировка

Внутрь (во время или после еды), по 1 таблетке каждые 4 ч, при болевом синдроме – 1-2 таблетки; средняя суточная доза – 3-4 таблетки, максимальная суточная доза – 8 таблеток. Курс лечения – не более 7-10 дней.

Препарат не следует принимать более 5 дней в качестве анальгезирующего ЛС и более 3 дней – жаропонижающего (без назначения и наблюдения врача). Др. дозировки и схемы применения устанавливаются врачом.

Особые указания

Детям нельзя назначать ЛС, содержащие АСК, поскольку в случае вирусной инфекции они способны увеличить риск возникновения синдрома Рейе. Симптомами синдрома Рейе являются продолжительная рвота, острая энцефалопатия, увеличение печени.

При продолжительном применении препарата необходим контроль периферической крови и функционального состояния печени.

Поскольку АСК замедляет свертывание крови, то пациент, если ему предстоит хирургическое вмешательство, должен заранее предупредить врача о приеме препарата.

Пациентам с повышенной чувствительностью или с астмоидными реакциями на салицилаты или их производные АСК можно назначать только с соблюдением специальных мер предосторожности (в условиях службы неотложной помощи).

АСК в низких дозах уменьшает выведение мочевой кислоты. У пациентов с соответствующей предрасположенностью это может в ряде случаев спровоцировать приступ подагры.

Во время лечения следует отказаться от употребления этанола (повышение риска желудочно-кишечного кровотечения).

АСК обладает тератогенным влиянием; при применении в I триместре приводит к пороку развития – расщеплению верхнего неба; в III триместре – к торможению родовой деятельности (ингибирование синтеза Pg), к закрытию артериального протока у плода, что вызывает гиперплазию легочных сосудов и гипертензию в сосудах малого круга кровообращения. Выделяется с грудным молоком, что повышает риск возникновения кровотечений у ребенка вследствие нарушения функции тромбоцитов.

Взаимодействие

Усиливает действие гепарина, непрямых антикоагулянтов, резерпина, стероидных гормонов и гипогликемических ЛС.

Одновременное назначение с др. НПВП, метотрексатом увеличивает риск развития побочных эффектов.

Уменьшает эффективность спиронолактона, фуросемида, гипотензивных ЛС, а также противоподагрических ЛС, способствующих выведению мочевой кислоты.

Барбитураты, рифампицин, салициламид, противоэпилептические ЛС и др. стимуляторы микросомального окисления способствуют образованию токсичных метаболитов парацетамола, влияющих на функцию печени.

Метоклопрамид ускоряет всасывание парацетамола.

Под воздействием парацетамола время выведения хлорамфеникола увеличивается в 5 раз. При повторном приеме парацетамол может усилить действие антикоагулянтов (производных дикумарина). Одновременный прием парацетамола и этанола повышает риск развития гепатотоксических эффектов.

Кофеин ускоряет всасывание эрготамина.

Даже самая убитая печень очищается этим средством!

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