Регистрационный номер: ЛП-002517
Торговое название: Флебофа®
Международное непатентованное название (МНН): диосмин
Лекарственная форма: таблетки
Состав на 1 таблетку:
Активное вещество: диосмин в пересчете на безводное вещество – 600 мг;
Вспомогательные вещества: желатин – 50,0 мг, карбоксиметилкрахмал натрия – 40,0 мг, магния стеарат – 10,0 мг, целлюлоза микрокристаллическая — до 1000 мг.
Описание: продолговатые двояковыпуклые таблетки с риской с одной стороны, от серовато-коричневого до серовато-желтого цвета, допускаются вкрапления более светлого и темного оттенков.
Фармакотерапевтическая группа:
Ангиопротекторное средство.
Код ATX: С05СА03
Фармакодинамика
Диосмин относится к группе биофлавоноидов, обладает флеботонизирующим (уменьшает растяжимость вен, повышает тонус вен (дозозависимый эффект), уменьшает венозный застой), улучшает лимфатический дренаж (повышает тонус и частоту сокращения лимфатических капилляров, увеличивает их функциональную плотность, снижает лимфатическое давление), улучшает микроциркуляцию (повышает резистент- ность капилляров (дозозависимый эффект), уменьшает их проницаемость), уменьшает адгезию лейкоцитов к венозной стенке и их миграцию в паравенозные ткани, улучшает диффузию кислорода и перфузию в кожной ткани, обладает противовоспа- лительным действием. Усиливает сосудосуживающее действие адреналина, норадреналина, блокирует выработку свободных радикалов, синтез простагландинов и тромбоксана.
Фармакокинетика
Диосмин быстро всасывается из желудочно-кишечно- го тракта. Обнаруживается в плазме крови через 2 часа после приема. Биодоступность препарата после приема внутрь составляет примерно 40 — 57,9 %. Часть препарата метаболизируется бактериями слепой кишки с образованием гиппуровой и бензойной кислот. Максимальная концентрация в плазме крови достигается через 5 часов после приема. Препарат накапливается во всех слоях стенки полых вен и подкожных вен нижних конечностей, в меньшей степени — в почках, печени и легких и других тканях. Объем распределения препарата составляет 62,1 л. Максимальное избирательное накопление диосмина и/или его метаболитов в стенке венозных сосудов отмечается через 9 часов после приема и сохраняет- ся в течение 96 часов. Диосмин быстро метаболизируется в печени. Основной метаболит — гидроксифенилпропионовая кислота. Метаболиты диосмина выводятся преимущественно почками в форме конъюгатов с глюкуроновой кислотой. 79 % принятого диосмина выводится почками, 11 % — кишечником, 2,4 % — с желчью. Отмечается энтерогепатическая циркуляция препарата. После приема диосмина, меченного радиоактивным изотопом, примерно 86 % препарата выводится почками и кишечником в течение 48 часов.
ПОКАЗАНИЯ К ПРИМЕНЕНИЮ
• Варикозное расширение вен нижних конечностей (устранение симптомов);
• Хроническая лимфовенозная недостаточность нижних конечностей (устранение симптомов);
• Острый геморрой (в комплексной терапии для облегчения симптомов);
• Нарушения микроциркуляции (например, при идиопатических отеках).
ПРОТИВОПОКАЗАНИЯ
• Повышенная чувствительность к компонентам препарата;
• Детский возраст до 18 лет (опыт применения ограничен);
• Беременность (I триместр) и период грудного вскармливания (опыт применения ограничен).
Применение при беременности и в период грудного вскармливания
Опыт применения препарата у беременных ограничен. О каких-либо нежелательных реакциях при применении диосмина у беременных в клинической практике не сообщалось. В экспериментальных исследованиях не было выявлено тератогенного воздействия диосмина на течение беременности, эмбриофетальное и постнатальное развитие. Тем не менее, по соображениям безопасности применение препарата в I триместре беременности противопоказано. При необходимости применения препарата во время II и III триместров беременности рекомендуется предварительно проконсультироваться с врачом.
Во время грудного вскармливания прием препарата не рекомендуется, т.к. отсутствуют данные о проникновении диосмина в грудное молоко.
СПОСОБ ПРИМЕНЕНИЯ И ДОЗЫ
Препарат предназначен для приема внутрь.
При варикозном расширении вен нижних конечностей и хронической лимфовенозной недостаточности
Препарат применяют по 1 таблетке в сутки утром натощак. Продолжительность терапии обычно составляет 2 месяца. При тяжелых формах хронической лимфовенозной недостаточности (отеки, боли, судороги и т.д.) лечение может быть более продолжительным (общая длительность непрерывной терапии не должна превышать трех-четырех месяцев). Курсы лечения препаратом Флебофа® повторяют через 2-3 месяца.
Для лечения хронической лимфовенозной недостаточности во время II и III триместра беременности препарат применяют по 1 таблетке 1 раз в день. Продолжительность терапии не более 30 дней. Необходимо прекратить прием препарата за 2-3 недели до родов.
При обострении геморроя
Препарат применяют по 2-3 таблетки в сутки во время еды в течение 7 дней. Далее при необходимости можно продолжить прием препарата по 1 таблетке 1 раз в день в течение 1-2 месяцев.
При нарушениях микроциркуляции
Препарат применяют по 1 таблетке в сутки утром натощак. Продолжительность терапии обычно составляет 1-2 месяца. Если пропущен один или несколько приемов препарата, необходимо продолжать применение препарата в обычном режиме и в обычной дозе.
Частота побочных эффектов определена в соответствии с классификацией ВОЗ нежелательных лекарственных реакций по частоте возникновения: очень часто — более 1/10, часто — более 1/100 и менее 1/10, нечасто — более 1/1000 и менее 1/100, редко — более 1/10000 и менее 1/1000, очень редко — менее 1/10000, включая единичные случаи; неизвестная частота (определить частоту встречаемости нежелательной реакции по имеющимся данным невозможно).
Со стороны желудочно-кишечного тракта: часто — тошнота, рвота, диарея (понос), диспептические расстройства, изжога, запор; нечасто — колит.
Со стороны центральной нервной системы: редко — головная боль, головокружение.
Со стороны кожи и подкожной жировой клетчатки, редко — кожные высыпания, кожный зуд;
Аллергические реакции: редко — крапивница, неизвестная частота — изолированный отек лица, губ, век; в исключительных случаях — ангионевротический отек (отек Квинке).
Общие расстройства: редко — недомогание.
Если любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу.
Случаи передозировки не описаны. Учитывая широкий терапевтический диапазон диосмина, риск интоксикации при передозировке представляется незначительным. Специфический антидот неизвестен. При передозировке препарата немедленно обратитесь за медицинской помощью!
ВЗАИМОДЕЙСТВИЕ С ДРУГИМИ ЛЕКАРСТВЕННЫМИ СРЕДСТВАМИ
Клинически значимые взаимодействия диосмина с другими лекарственными средствами не описаны.
Лечение острого геморроя проводят в комплексе с другими препаратами. При отсутствии быстрого клинического эффекта рекомендуется проконсульти- роваться с проктологом, при необходимости провести дополнительное обследование и скорректировать проводимую терапию.
При нарушениях венозного кровообращения (варикозное расширение вен нижних конечностей, хроническая лимфовенозная недостаточность нижних конечностей) максимальный эффект лечения обеспечивается сочетанием терапии с изменениями образа жизни: желательно избегать длительного пребывания в вертикальном положении, уменьшить избыточную массу тела. В некоторых случаях улучшению циркуляции крови способствует ношение специальных чулок (компрессионного трикотажа).
Опыт применения диосмина у детей младше 18 лет недостаточен. В случае отсутствия уменьшения или при утяжелении симптомов заболевания обратитесь к врачу! Не превышайте максимальные сроки и рекомендованные дозы препарата без согласования с врачом!
Влияние на способность управлять транспортными средствами и механизмами
Препарат не оказывает влияния на способность управлять транспортными средствами и механизмами.
Таблетки 600 мг.
По 10 таблеток в контурную ячейковую упаковку из пленки поливинилхлоридной и фольги алюминиевой печатной лакированной.
По 10, 20, 30, 40, 50, 60 или 100 таблеток в банку полимерную для лекарственных средств.
Одну банку или 1, 2, 3, 4, 5, 6, 7, 8, 9 или 10 контурных ячейковых упаковок вместе с инструкцией по применению помещают в картонную упаковку (пачку).
Допускается комплектация по 2 или 3 картонные упаковки (пачки) в групповую упаковку (транспортная тара) из картона.
Срок годности 3 года.
Не использовать после истечения срока годности.
Условия хранения
При температуре не выше 25 °С. Хранить в недоступном для детей месте.
Условия отпуска из аптек
Отпускают без рецепта.
Юридический адрес: 445351, Россия, Самарская обл., г. Жигулевск, ул. Песочная, д. 11.
Адрес производства, в том числе для переписки и приема претензий: 445351, Россия, Самарская обл., г. Жигулевск, ул. Гидростроителей, д. 6.
Флебофа: инструкция по применению и отзывы
Латинское название: Phlebopha
Код ATX: C05CA03
Действующее вещество: диосмин (diosmin)
Производитель: Озон, ООО (Россия)
Актуализация описания и фото: 25.10.2018
Цены в аптеках: от 229 руб.
Флебофа – ангиопротекторное средство, оказывающее венотонизирующее действие.
Форма выпуска и состав
Выпускают Флебофу в форме таблеток: двояковыпуклые, продолговатые, на одной из сторон с риской, от серо-коричневого до серо-желтого цвета с возможными вкраплениями более светлого и темного оттенков (10 шт. в контурной ячейковой упаковке, в картонной пачке 1–10 упаковок; 10, 20, 30, 40, 50, 60 или 100 шт. в полимерной банке, в картонной пачке 1 банка; допускается комплектация 2 или 3 картонных пачек в картонную упаковку).
В 1 таблетке содержатся:
- действующее вещество: диосмин – 0,6 г (в пересчете на безводное вещество);
- дополнительные компоненты: карбоксиметилкрахмал натрия, целлюлоза микрокристаллическая, магния стеарат, желатин.
Фармакологические свойства
Фармакодинамика
Диосмин – производное бензопирона; входит в группу биофлавоноидов, оказывает флеботонизирующее и венопротекторное действие, уменьшает проницаемость сосудистой стенки. Вещество способствует снижению растяжимости и повышению тонуса вен, уменьшению венозного застоя в нижних конечностях. Венотонизирующее действие средства является дозозависимым, его механизм полностью не выяснен. Допускается, что активное вещество Флебофы блокирует активность катехол-О-метилтрансферазы, приводящей к распаду норадреналина, повышающего тонус вен. Подтверждение этой гипотезы получено при проведении экспериментальных исследований в условиях ex vivo, в ходе которых диосмин обеспечивал усиление вазоконстрикторного эффекта серотонина, адреналина и норадреналина на отделенные фрагменты большой подкожной вены и поверхностных вен предплечья. Также вследствие влияния вещества было отмечено снижение сывороточной концентрации ферментов, регулирующих метаболизм мукополисахаридов в венозной стенке.
Согласно данным клинических исследований диосмин содействует снижению емкости венозного русла и объема венозного застоя (по результатам окклюзионной плетизмографии), уменьшению среднего давления в поверхностных и глубоких венах ног (по результатам ультразвуковой допплерографии) и повышению систолического и диастолического артериального давления (АД) на фоне послеоперационной ортостатической гипотензии. Повышая частоту сокращения и тонус лимфатических капилляров, увеличивая их функциональную плотность и снижая лимфатическое давление, препарат усиливает лимфатический дренаж.
Благодаря эффекту диосмина улучшаются процессы микроциркуляции крови – повышается резистентность капилляров (имеет дозозависимый характер) и снижается их проницаемость. Вещество способствует уменьшению адгезии лейкоцитов к венозной стенке и их перемещению в паравенозные ткани, улучшению диффузии кислорода и перфузии в кожной ткани. Обладая противовоспалительным действием, Флебофа угнетает продукцию простагландинов и тромбоксана и выработку свободных радикалов.
Фармакокинетика
После приема таблеток Флебофа диосмин быстро абсорбируется из желудочно-кишечного тракта (ЖКТ) и выявляется в плазме крови спустя 2 часа после приема. Биодоступность вещества при пероральном приеме – около 40–57,9%. В процессе метаболической трансформации части препарата с участием бактерий слепой кишки образуются гиппуровая и бензойная кислоты. Максимальная концентрация вещества в плазме отмечается спустя 5 часов после приема. Накопление диосмина протекает во всех оболочках стенок подкожных вен нижних конечностей и полых вен, в меньшей степени – в легких, печени, почках и других тканях.
Объем распределения – 62,1 л, максимальное значение избирательного накопления диосмина и/или его метаболитов отмечается в стенке вен через 9 часов после приема и сохраняется на продолжении 96 часов. Средство быстро биотрансформируется в печени с образованием основного метаболита – гидроксифенилпропионовой кислоты. Экскретируются метаболиты диосмина главным образом почками в виде конъюгатов с глюкуроновой кислотой. Почками выводится 79% принятого вещества, кишечником – 11%, с желчью – 2,4%.
Для Флебофы характерна энтерогепатическая циркуляция. После приема меченного радиоактивным изотопом диосмина около 86% выводится кишечником и почками в течение 48 часов.
Показания к применению
- варикозное расширение вен нижних конечностей (для устранения симптомов);
- хроническая форма лимфовенозной недостаточности нижних конечностей (для устранения симптомов);
- острая форма геморроя (в комбинированной терапии в целях облегчения симптомов);
- нарушения процессов микроциркуляции (например, в случае идиопатических отеков).
Противопоказания
- возраст до 18 лет;
- I триместр беременности;
- период лактации;
- гиперчувствительность к составляющим средства.
Инструкция по применению Флебофы: способ и дозировка
Таблетки Флебофа принимают перорально.
Рекомендованный режим дозирования с учетом показаний:
- варикозное расширение вен нижних конечностей: принимают натощак утром по 0,6 г (1 таблетка), курс в среднем составляет 2 месяца;
- хроническая лимфовенозная недостаточность: принимают натощак утром по 0,6 г, средний курс – 2 месяца; при тяжелых формах заболевания (судороги, боли, отеки и т. д.) возможно назначение более длительно курса, но общая продолжительность непрерывной терапии не должна быть более 4-х месяцев, проведение повторных курсов допускается с перерывами в 2–3 месяца; при лечении заболевания во II и III триместрах беременности препарат принимают 1 раз в сутки в дозе 0,6 г, длительность приема – не более 1 месяца, терапию необходимо завершить за 2–3 недели до родов;
- обострение геморроя: принимают во время еды, суточная доза – 1,2–1,8 г (2–3 таблетки), курс – 7 дней, в дальнейшем при необходимости возможен прием 1 раз в сутки по 0,6 г (1 таблетке) на протяжении 1–2 месяцев;
- нарушения микроциркуляции: принимают натощак утром по 0,6 г, курс – 1–2 месяца.
В случае пропуска одного или нескольких приемов Флебофы лечение следует продолжать в обычном режиме в рекомендованных дозировках.
Побочные действия
- центральная нервная система: редко – головокружение, недомогание, головная боль;
- ЖКТ: часто – рвота, изжога, тошнота, запор, диарея, диспептические расстройства; нечасто – колит;
- аллергические реакции: редко – крапивница; с неизвестной частотой – изолированный отек губ, век, лица; крайне редкие случаи – ангионевротический отек;
- кожа и подкожная жировая клетчатка: редко – кожный зуд, кожные высыпания.
Передозировка
Случаи передозировки не установлены. В связи с широким терапевтическим диапазоном диосмина вероятность интоксикации при его передозировке незначительна. Специфического антидота нет.
Особые указания
Если при комбинированной терапии острого геморроя не удается достичь быстрого клинического эффекта, требуется получить консультацию проктолога и при необходимости после дополнительного обследования осуществить корректировку проводимого лечения.
При нарушениях венозного кровообращения в целях достижения максимального эффекта от приема Флебофы желательно в период терапии по возможности снизить избыточный вес тела и избегать продолжительного пребывания в положении стоя. В некоторых случаях может быть рекомендовано ношение компрессионного трикотажа для улучшения циркуляции крови.
Если на фоне приема Флебофы не наблюдается снижение выраженности симптомов заболевания или отмечается усугубление их проявлений, следует обратиться к врачу.
Влияние на способность к управлению автотранспортом и сложными механизмами
Согласно инструкции, Флебофа не оказывает негативного действия на способность пациента к управлению транспортными средствами и различными механизмами.
Применение при беременности и лактации
Опыт использования Флебофы в период беременности ограничен. О каких-либо вредных последствиях применения диосмина у беременных женщин в клинической практике сообщений не имеется. При проведении экспериментальных исследований тератогенного воздействия препарата на развитие плода выявлено не было. Однако из соображений безопасности принимать средство в I триместре беременности противопоказано.
В случае необходимости использования препарата во II и III триместрах беременности требуется получить предварительную консультацию у специалиста.
Кормящим грудью женщинам прием Флебофы противопоказан, поскольку нет сведений о его проникновении в материнское молоко.
Применение в детском возрасте
Пациентам младше 18 лет принимать препарат противопоказано т. к. исследования по его применению у детей и подростков не проводились.
Лекарственное взаимодействие
Сведения о клинически значимых взаимодействиях диосмина с другими лекарственными веществами/препаратами отсутствуют.
Аналоги
Сроки и условия хранения
Хранить в месте, защищенном от проникновения света и недоступном для детей, при температуре, не превышающей 25 °С.
Срок годности – 3 года.
Условия отпуска из аптек
Отпускается без рецепта.
Отзывы о Флебофе
Отзывы о Флебофе в большинстве своем положительные. Пациенты, получавшие препарат, отмечают его эффективность при лечении варикозного расширения вен и обострения геморроя. Согласно отзывам, средство способствует снижению венозного застоя, повышению тонуса вен и капилляров, снимает отечность, боли и тяжесть в ногах. Пациенты отмечают удобную схему приема средства, и то, что его стоимость ниже аналогичных по действию импортных средств. Это имеет большое значение при прохождении планового курса терапии.
К недостаткам препарата относят развитие таких нежелательных реакций, как слабость, тошнота, изжога, боли в эпигастральной области, диарея.
Цена на Флебофу в аптеках
Цена на Флебофу может примерно составлять: таблетки 600 мг (30 шт. в упаковке) – от 880 до 930 рублей.
Инструкция по применению
Немного фактов
Флебофа – быстродействующее лекарство, которое положительно влияет на сосуды и вены. Это средство поможет избавиться от застоя крови в венах, от болезненных отеков и от синих и красных прожилок на нижних конечностях. Стенки сосудов станут эластичными и упругими, что позволит навсегда забыть о варикозе.
Флебофа: фармакология
Лекарство является ничем иным, как биофлавоноидом и ангиопротекторным средством, оказывающим венотонизирующее действие. Главное действующее вещество это Диосмин, его относят к группе биофлавоноидов. Благодаря этому веществу можно значительно снизить проницаемость стенок сосудов, уменьшить растяжимость, а также значительно повысить тонус вен.
Действующее вещество препарата благоприятно влияет на лимфатическую систему: повышает тонус, эластичность и частоту сокращения лимфатических капилляров, помогает им функционировать и снижает давление в лимфах.
Флебофа очень быстро всасывается из ЖКТ и попадает в кровоток, этот процесс занимает около 2 часов. Максимальная концентрация активного вещества наблюдается в плазме крови уже спустя 5 часов после момента самого приема медикаментозного средства. Диосмин максимально накапливается и начинает активно работать в стенках венозных сосудов через 9 часов после употребления 1 таблетки и не меняет свое местоположение на протяжении 96 часов. Активное вещество выводят не только почки, но и кишечник на протяжении 2 суток.
Составляющие компоненты и форма выпуска
Форма выпуска Флефобы – таблетки, которые на вид имеют коричнево-серый цвет. Внешний вид капсул. Состав одной таблетки: 600 мг Диосмина, 50 мг Желатина, 40 мг Карбоксиметилкрахмал, 10 мл Магния Стеарата, 950 мл Микрокристаллической целлюлозы.
При каких заболеваниях применяется препарат
Применение Флебофы рекомендуется в случаях:
- Хронических заболевания вен (венозная недостаточность).
- Варикоза.
- Слабости и ломкости сосудов.
- Лимфовенозной недостаточности.
- Геморрое.
- Нарушении циркуляции крови.
Медикаментозное средство эффективно борется с рядом заболеваний и показывает положительный результат: улучшает циркуляцию крови, уменьшает проницаемость сосудов, питает органы кислородом, снимает воспаление и отеки, препятствует застаиванию крови в венах на ногах.
Противопоказания и возможные побочные эффекты
Применение лекарства не рекомендуется:
- детям до 18 лет;
- аллергикам или при появлении аллергической реакции на компоненты Флебофы;
- при болезнях печени;
- при индивидуальной непереносимости компонентов лекарства;
- беременным и кормящим мамам.
Если противопоказания не пугают, можно спокойно приступать к лечению болезни и ничего не бояться. В каждом лекарстве могут быть побочные эффекты, к которым необходимо быть готовыми.
Побочное действие таблеток
Кожные высыпания, мигрени, расстройства или запоры. Если не изучить инструкцию по применению лекарства перед его приемом и рассчитать неверно дозировку, может возникнуть незначительная передозировка. Активное вещество не наносит фатального вреда здоровью при превышении количества капсул, но лучше не шутить с этим. Антидот к медикаменту не найден.
При неправильном лечении и появлении побочных действий стоит прекратить употребление таблеток и проконсультироваться с опытным врачом.
Способ и особенности применения Флебофы
Препарат применяется в разных дозах во время заболеваний:
- Варикоз. 1 таблетка с утра на пустой желудок, пить на протяжении 2 месяцев. Повторять курс рекомендуется через 1-2 месяца в случае, если самочувствие пациента остается нормальным. Во время беременности суточная доза составляет 1 таблетку в день. За месяц до даты родов прием медикаментов стоит прекратить.
- Лимфовенозная недостаточность. Употреблять таблетки (по 1 в день) можно на протяжении четырех месяцев, не более.
- Хронический или острый геморрой. Первую неделю Флебофу необходимо принимать при следующей дозировке: 2-3 капсулы в день во время приема пищи. Затем необходимо пройти терапию, как при варикозе, на протяжении одного-двух месяцев.
- Замедленная циркуляция крови. Капсулы пьют 1 раз в день утром и натощак на протяжении одного-двух месяцев.
Перед употреблением медикаментов нужно прочесть информационный вкладыш внутри Инструкция препарата позволит безошибочно назначить курс терапии даже без врача, но лучше и безопасней перед употреблением капсул проконсультироваться с лечащим доктором. Особенно это касается беременных и кормящих женщин.
Взаимодействие с другими лекарствами и алкоголем
При употреблении Флебофы и других медикаментов, не обнаружено негативных влияний и показаний, чтобы заблаговременно прекратить пить капсулы. Медикаментозное средство не влияет на способность управлять средствами передвижения и прочими механизмами.
Как таблетки влияют на организм человека, если взаимодействуют с алкоголем, не изучено. Для лучшего эффекта от препарата лучше не смешивать алкогольные напитки во время приема таблеток. Эту информацию необходимо уточнить у доктора, чтобы не навредить своему здоровью.
Условия продажи и хранения
Отпускают медикамент по именному рецепту, который выписывает лечащий врач, при наличии показаний варикоза, геморроя и других болезней.
Оригинальная упаковка лекарства с активным веществом Диосмином.
Условия хранения препарата: в недоступном для малышей месте, при температуре не более 25 градусов за Цельсием и чтобы не попадали солнечные лучи на таблетки, иначе их состав может испортиться и не принести никакого положительного результата.
Аналоги таблеток
Иногда в аптеке нельзя найти нужные медикаменты, тогда дружелюбные фармацевты предлагают аналоги с тем же активным веществом. Аналоги Флебофы:
- Флебодиа. Медикаментозное средство, которое предотвращает венозные застои, увеличивает функциональную плотность капилляров и сосудов, снимает воспалительные процессы, болезненные отеки на ногах возле вен, уменьшает боли в ногах, устраняет красные и синие кровеносные сетки и выступающие вены. Флебодиа – достойный аналог. Медикамент способен усилить воздействие адреналина, таким образом, будет спровоцировано сужение сосуд.
- Вазокет – средство, которое повышает тонус вен и сосудов, улучшает лимфодренаж, уменьшает в несколько раз застой крови в венах. Эффективный результат его прием даст только при правильном курсе терапии и употреблении капсул. Правильно рассчитанные дозы – залог быстрого и безболезненного выздоровления пациента.
- Диосмин поможет раз и навсегда избавиться от растяжимости вен, уменьшает в несколько раз проницаемость капилляров и сосудов. При приеме таблеток улучшается кровообращение в ногах, поэтому можно не беспокоиться о деформации вен, боли в нижних конечностях, опухании и воспалении вен.
- Венолек. Компоненты Венолека оказывают венотонизирующий и противовоспалительные эффекты, повышают тонус и эластичность сосудов, уменьшают растяжимость вен на нижних конечностях, значительно улучшают циркуляцию крови и лимфоотток.
Эти четыре препарата по отзывам реальных людей, которые боролись с варикозами, болезнями лимфатической системы, наиболее подходящие и приносят лучший эффект. Все они выписываются исключительно доктором и стоимость их разная.
Считается одним из наиболее результативных медикаментов, эффект которого, не нужно ждать долго. Высококачественные таблетки, сделаны добросовестной фирмой-производителем, прошли все проверки и отвечают международным фармакологическим требованиям.
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