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Флебодия600 или детралекс что лучше при геморрое

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17 августа 2019

Известно, что геморрой часто сопровождается таким неприятными симптомами как сильная боль, отечность в области заднепроходного канала, нарушение микроциркуляции и оттока лимфы и как следствие увеличение геморроидальных узлов.

Проктологи утверждают, что справиться с острыми признаками геморроидальной болезни можно с помощью лекарственных препаратов, относящихся к группе ангиопротекторов. Безусловными фаворитами здесь являются Детралекс и Флебодиа. Многих пациентов волнует вопрос: что лучше Флебодиа или Детралекс? Какое лекарственное средство помогает достичь более стойкого и продолжительного эффекта?

Сравнительная характеристика состава

В первую очередь следует отметить, что Флебодиа и Детралекс являются аналогами, оба препарата производятся во Франции. Их наиболее часто применяют в стандартных схемах лечения варикоза ног и геморроя в острой или хронической стадии.

Несмотря на схожее действие, лекарственные средства несколько отличаются друг от друга составом:

  • Основными компонентами в составе Детралекса являются диосмин в количестве 450 мг или 950 мг в зависимости от дозировки и гесперидин в количестве 50 мг. Эти вещества, являются флавоноидами и усиливают действие друг друга.
  • Главное действующее вещество таблеток Флебодиа – диосмин, содержащийся в количестве 600 мг.

Оба препарата предназначены для восстановления функций и нормальной работы сосудов, а также для их укрепления. Они устраняют ломкость, снижают проницаемость сосудистых стенок, повышают тонус сосудов, делая их более прочными и эластичными, способными выдерживать нормальное давление крови и при этом не оказывают негативного влияния на организм человека. Научно доказано, что диосмин равномерно распределяется по всем слоям сосудистых стенок, в большем количестве в полых венах ног и малого таза и в малом количестве в печени, почках и легких.

В отличие от таблеток Флебодиа диосмин в составе Детралекса подвергается особой обработке – микронизированию. Благодаря этому вещества в составе средства, в отличие от Флебодиа, быстрее абсорбируются из желудка, всасываясь в системный кровоток, и намного быстрее начинают действовать.

Максимальное содержание вещества в плазме крови наблюдается уже через 4 часа после приема Детралекса. Также он отличается более продолжительным периодом биотрансформации, при котором происходит выделение фенольных кислот, период полувыведения диосмина и гесперидина составляет около 11 часов.

Особенности применения

Оказываемое препаратами лечебное действие напрямую зависит от дозировки.

При остром геморрое согласно инструкции принимают:

  • таблетки Флебодиа 3 раза в день по 1 шт. в течение 7 дней, далее по одной таблетке в день, длительность приема зависит от клинической картины развития геморроидальной болезни. Таблетки можно принимать вне зависимости от приемов пищи, в любое время дня;
  • таблетки Детралекс от 4 до 6 шт. в день в течение 7 дней, далее по 2 шт. в день, длительность приема также зависит от степени развития геморроя. Таблетки следует принимать во время еды, запивая большим количеством воды. Дозировку в 1000 мг, принимают по 1 таблетке в день.

Оба лекарственных средства можно использовать для лечения и профилактики хронического геморроя. Минимальный курс терапии составляет 2 месяца, далее по показаниям.

Детралекс выпускается в упаковках по 30 и 60 таблеток, стоимость которых составляет 700-800 рублей (30 шт.) и 1400-1500 рублей (60 шт.). Детралекс также выпускают с дозировкой в 1000 мг, соответственно цена за 30 таблеток – 1250-1300, за 60 – 2250-2300 рубле.

Флебодиа 600 выпускается в упаковках по 15, 30 и 60 таблеток. Соответственно цена препарата: 500-600 рублей (15 шт.) и 800-900 рублей (30 шт.) и 1400-1450 (60 шт.).

Путем несложных подсчетов, учитывая приведенные в инструкции по применению дозировки, стоимость лечения острого или хронического геморроя таблетками Детралекс обойдется практически в 2 раза дороже.

Оба лекарственных средства не относятся к категории бюджетных средств, но пациенты, сомневающиеся, что лучше Флебодиа или Детралекс, должны знать, что оба препарата имеют высокое качество и длительную практику применения многими больными. Лекарства соответствуют всем современным европейским стандартам, имеют необходимые сертификаты и прошли все обязательные испытания, прежде чем поступить в продажу.

Если бюджет все-таки не позволяет воспользоваться столь дорогими препаратами, обратите внимания на более дешевые, но не менее эффективные отечественные аналоги, например, Венарус. Он имеет аналогичный состав и те же показания к применению.

Показания к применению и противопоказания

Детралекс или Флебодиа, что лучше при геморрое и варикозе? Согласно инструкции таблетки Флебодиа и Детралекс имеют идентичные показания к применению:

  • острый или хронический варикоз вен нижних конечностей;
  • острый или хронический геморрой, сопровождающийся тромбозом геморроидальных вен, выпадением узлов, кровоточивостью, отеками болями и воспалением;
  • комплексная терапия при нарушениях микроциркуляции и оттока лимфы.

Учитывая показания к применению, а также отзывы пациентов и врачей, при лечении геморроя и варикоза вен эффективны оба препарата.

Противопоказаниями к использованию таблеток Детралекс являются только сверхчувствительность к диосмину или гесперидину.

Список противопоказаний препарата Флебодиа 600 намного больше. Его запрещается применять:

  • во время кормления грудью;
  • в детском и подростковом возрасте (до 18 лет);
  • в первые 13 недель беременности;
  • при сверхчувствительности к диосмину.

Из побочных эффектов оба препарата могут стать причиной следующих нарушений:

  • изжога, тошнота, боли в животе;
  • аллергия на коже: мелкая сыпь, крапивница, покраснение;
  • головная боль, головокружение, нарушения сна.

Также следует учитывать, что 80% лекарства Флебодиа выводится почками, а 86% Детралекса печенью, это следует учитывать при выборе того или иного препарата и при имеющихся проблемах в работе данных органов.

Следует помнить, что при появлении побочных реакций при приеме таблеток лечение следует прекратить и обратиться за консультацией к врачу.

Флебодиа и Детралекс не оказывают никакого влияния на внимание и скорость реакции. Поэтому их можно применять представителям сильного пола, работающим на тяжелых и опасных производствах, где требуется полная сосредоточенность на процессе.

Мнения пациентов и врачей

В настоящее время есть много положительных отзывов пациентов и врачей о лечебном эффекте, который оказывают оба препарата. При сравнении данных лекарственных средств можно утверждать, что и Детралекс, и Флебодиа 600 при варикозном расширении вен нижних конечностей помогают быстро избавиться от боли в ногах и отеках, снять ощущение тяжести и усталости, избавиться от некрасивой сосудистой сеточки. При геморрое препараты помогают нормализовать кровоток в околопрямокишечных тканях, снять воспаление, боль, отеки, уменьшить геморроидальные узлы и укрепить сосудистые стенки, уменьшая вероятность возникновения рецидивов.

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По статистике побочные реакции даже при длительном использовании таблеток возникали в очень редких случаях.

Детралекс и Флебодиа – два лекарственных средства, которые являются приоритетным выбором для лечения геморроя и венозной недостаточности из-за их высокого качества и проверенного терапевтического и профилактического действия, поэтому их высокая цена вполне оправдана.

Заключение

Флебодиа 600 или Детралекс: что же все-таки лучше? Учитывая характеристики препаратов, отзывы пациентов и врачей можно сделать следующий вывод:

  • Детралекс лучше применять при остром геморрое и резко развивающейся венозной недостаточности, которые сопровождаются сильными отеками, ярко выраженной болью, сильным воспалением. Данный препарат быстрее всасывается в системный кровоток и оказывает более быстрое терапевтическое действие. Именно эти таблетки могут быть рекомендованы больным, имеющим проблемы с желудочно-кишечным трактом из-за их более щадящего воздействия.
  • Флебодиа 600, благодаря оптимальному количеству содержащегося в ней диосмина, заметно сокращает сроки лечения хронической геморроидальной болезни и венозной недостаточности. Но ее также можно применять и при острых признаках патологии.

Таким образом, учитывая быстроту действия и имеющиеся противопоказания, безусловным фаворитом из этих двух препаратов является Детралекс. Но, зато Флебодиа более проста в применении, наиболее эффективна и выгодна в лечение хронического геморроя и венозной недостаточности.

Однако не следует забывать, что оба лекарственных средства принимают перорально. Проктологи предупреждают, что ни Детралекс, ни Флебодиа не должны заменять терапию другими лекарственными препаратами: мазями, гелями, ректальными свечами при любой степени тяжести и форме геморроя или варикоза.

При венозной недостаточности у пациентов возникают жалобы на отеки, болевые ощущения в нижних конечностях, нарушена микроциркуляция и лимфотток. В ходе комплексной терапии возникающих нарушений в качестве препаратов базисной терапии флебологи используют ангиопротекторы и венотоники.

Наиболее часто назначают Детралекс или Флебодиа – лекарственные препараты-венотоники, которые являются аналогами и способствуют оказанию ангиопротекторных и венотонизирующих эффектов. Активные вещества устраняют венозный застой, уменьшают растяжимость вен, нормализуется проницаемость капилляров, происходит повышение их резистентности.

Фармакологическое действие

Фармакологическое действие обоих препаратов основано на их способности оказывать следующие терапевтические эффекты:

  • Флеботонизирующий – лекарства способствуют уменьшению растяжения венозных стенок, повышению тонуса вен, уменьшению венозного застоя.
  • Нормализовать лимфодренаж – при лимфостазе наблюдается повышение тонуса и частоты сокращения капилляров, устраняются отеки ног, увеличивается функциональная плотность капилляров.
  • Ангиостереометические исследования указывают, что оба препарата способствуют оказанию положительного терапевтического эффекта на кровоток. Активные вещества нормализуют микроциркуляцию, оказывают противовоспалительное действие.

Наблюдается усиление сосудосуживающего эффекта адреналина и норадреналина, блокировка выработки свободных радикалов, синтеза простагландинов и тромбоксанов.

Показания

Детралекс используют в соответствии со следующими показаниями к приему:

  • Комплексная терапия венозно-лимфатической недостаточности в виде болевых ощущений, чувства тяжести в ногах, утренней усталости ног.
  • Симптоматическое лечение обострений геморроя.

Флебодиа может быть использована при выявлении следующих патологических состояний:

  • Варикозного расширения вен нижних конечностей.
  • Хронической лимфовенозной недостаточности ног.
  • Геморроя.
  • Нарушений микроциркуляции.

Пациенты, которые задают вопросы о том, что лучше при варикозе или что лучше при геморрое должны учитывать, что все зависит от результатов комплексного обследования и степени развития болезни.

Например, при тромбофлебите препараты используют в качестве вспомогательного средства лечения и для профилактики прогрессирования заболевания. В тяжелых случаях использования лекарственных препаратов может оказаться недостаточно, и врачи задействуют малоинвазивных и хирургические методы лечения.

Сравнительная характеристика лекарств

Оба препарата производят крупные французские фармацевтические компании. Важно сравнить препараты, чтобы знать, чем отличаются лекарства и иметь представление о количественном содержании активных компонентов, стоимости и качестве таблеток.

Флебодиа Детралекс
Активный компонент Диосмин в пересчете на сухое вещество – 600 мг Очищенная микронизированная флавоноидная фракция, в состав которой входит диосмин (450 мг, 90%) и флавоноиды в виде геспередина (50 мг, 10%)
Описание Круглая таблетка, окрашенная в розовый цвет Овальная таблетка, окрашенная в оранжево-розовый цвет
Противопоказания Непереносимость действующих веществ лекарства, период лактации, терапия пациентов младше 18-летнего возраста. Непереносимость активных или вспомогательных веществ, терапия кормящих женщин. При необходимости использования лекарства в ходе лечения кормящих мам необходимо рассматривать вопрос о прекращении ГВ.
Особенности применения Начальная стадия варикозного расширения вен и хроническая лимфовенозная недостаточность, сопровождающая тяжестью в ногах: 1 таблетка в утреннее время, перед основным приемом пищи на протяжении 2 месяцев. При выраженных ухудшениях курс приема – до 4 месяцев. В том случае, если наблюдаются трофические нарушения, то продолжительность приема – до полугода и дольше. Курс терапии можно повторять после перерыва в 2-3 месяца.

Обострение геморроя: 2-3 таблетки в день во время основного приема пищи на протяжении 7 дней. Далее – по 1 таблетке в сутки на протяжении нескольких месяцев.
Хроническая лимфовенозная недостаточность на протяжении 2 и 3 триместра беременности: 1 таблетка в день. Прием лекарства необходимо прекратить за несколько недель до рождения ребенка.

В том случае, если пациент пропускает прием препарата один или несколько раз рекомендовано продолжать использовать лекарство по стандартной схеме, предложенной производителем или лечащим врачом.

Венозно-лимфатическая недостаточность: 1 таблетка днем и 1 таблетка вечером во время основного приема пищи.

Острый геморрой: 6 таблеток в течение дня. 3 таблетки в утреннее время суток и 3 в вечернее на протяжении 4 дней. После этого переход на прием 4 таблеток в сутки: 2 в утреннее и 2 в вечернее время на протяжении последующих 3 дней.

Побочные эффекты В редких случаях могут возникать побочные эффекты в виде диспепсических нарушений и головной боли, которые требуют временного прекращения использования таблеток. В том случае, если побочные реакции усугубляются рекомендовано проконсультироваться с врачом. В редких случаях сообщалось о развитии головокружения, головной боли, общего недомогания, диареи, диспепсии, тошноты, рвоты, колитов, сыпи, зуда, крапивницы. Производитель рекомендует информировать врача о развитии любых нежелательных побочных эффектов, в том числе, не указанных в инструкции. Возможность использования при беременности Не сообщалось о развитии нежелательных побочных реакций у беременных женщин. Экспериментальные исследования не выявили тератогенное воздействие на плод. Исследования на животных тератогенного действия не выявили, о побочных реакциях среди беременных женщин не сообщалось. Фармакокинетика Активное вещество проникает в кровоток спустя 120 минут после приема, достижение максимальной концентрации в плазме крови – спустя 5 часов после применения препарата. Равномерное распределение и накапливание в стенках полых и подкожных вен ног. Активный компонент избирательно накапливается в области венозных сосудов, достижение максимальной концентрации – спустя 9 часов после приема. Эффект сохраняется на протяжении 96 часов. Выведение активных компонентов осуществляется вместе с каловыми массами. Продолжительность периода полувыведения – 11 часов. Цена От 670 руб. От 760 руб.
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Решение о том, что выбрать в ходе комплексного лечения венозных патологий лучше доверять квалифицированному врачу-флебологу.

Отзыв врача о Детралексе (видео)

Возможные аналоги

У препаратов Детралекс и Флебодиа существуют структурные аналоги, которые содержат в своем составе диосмин, среди них:

  • Венарус (от 580 руб.)
  • Дафлон (французский препарат, стоимость 2000 руб.)
  • Детравен – белорусский аналог, который встречается в аптеках Белоруссии.
  • Венозол – комбинированный препарат, в состав которого, помимо диосмина, также входит геспередин, экстракт листьев орешника, дигидрокверцетин, конский каштан.
  • Венодиол – препарат на основе диосмина, геспередина, аскорбиновой кислоты.
  • Вазокет – используют в составе комплексной терапии совместно с другими группами лекарственных средств.

На фармацевтическом рынке также есть лекарственные средства, в состав которых входят другие действующие вещества, однако фармакологическая группа – общая с Детралексом и Флебодией:

  • Венорутон (от 890 руб.)
  • Троксевазин (от 400 руб.) – биофлаваноид, который способствует укреплению сосудистой стенки, уменьшению проницаемости и ломкости капилляров, нормализации микроциркуляции, оказанию противоотечного действия.
  • Троксерутин (от 280 руб.) – аналог Троксевазина, способствующий оказанию венотонизирующего и ангиопротекторного действия.
  • Гинкор Форт – препарат на основе экстракта гинкго билобы, который может быть использован на протяжении 2 и 3 триместра беременности по рекомендации и под наблюдением врача.
  • Эскузан (от 230 руб.) – фитопрепарат на основе экстракта семян конского каштана, способствующий оказанию антиэкссудативного и венотонизирующего действия.
  • Антистакс (от 1020 руб.) – препарат на основе сухого экстракта красных листьев винограда, который снижает проницаемость капилляров и способствует оказанию ангиопротекторного действия.

Часто пациенты интересуются о том, что эффективнее принимать, чтобы добиться быстрого терапевтического результата. Оба препарата имеют растительное происхождения, поэтому прием лекарств должен осуществляться на протяжении длительного времени. Для того, чтобы достичь более выраженного эффекта врач может посоветовать одновременный прием с другими группами лекарственных средств.

Отзывы

Отзывы врачей о препаратах преимущественно положительные. Препараты демонстрируют наибольшую эффективность, если использовать их в составе комплексной терапии совместно с другими группами лекарств, а также компрессионным трикотажем.

Дополнительные рекомендации

Сформированная стоимость данных лекарственных средств обусловлена высоким качеством лекарственного сырья: препараты соответствуют европейскому стандарту качества, проходят все необходимые исследования, прежде, чем поступают в продажу. Для того, чтобы улучшить терапевтические действие флеботоников и ангиопротекторов рекомендовано дополнительное использование лекарств для наружного нанесения в форме мазей, кремов и гелей, а также прием корректоров микроциркуляции.

О Флебодии (видео)

Флебодиа – лекарственный препарат, в состав которого входит диосмин (600 мг).

Детралекс – это комбинированное средство, которое состоит из диосмина (450 мг) и гесперидина (50 мг).

Гесперидин и диосмин относят к группе флавоноидов. В фармакологической классификации АТХ диосмин обозначается кодом C05CA03, а комбинация диосмина и гесперидина – C05CA53. Медикаментозный препарат «Флебодиа»

Внимание! Венотонизирующие флавоноиды используются в клинической практике для лечения венозных заболеваний различной этиологии.

Показания к назначению флавоноидов

Флавоноиды используются в качестве венотозирующих средств. Они снимают отеки оказывают положительный инотропный, антигипертензивный эффект. Имеют легкое гепатопротекторное, спазмолитическое и диуретическое действие, что в основном объясняется антиоксидантными свойствами и ингибированием ферментов. Флавоноиды

Эпидемиологические исследования и большинство исследований in vivo показывают, что флавоноиды оказывают положительное влияние при различных сосудистых заболеваниях. Традиционно эти эффекты приписывались только антиоксидантному действию флавоноидов.

Однако в дополнение к прямому связыванию активных форм кислорода (АФК) зафиксирован ряд других эффектов, которые в фармакологически достижимых концентрациях тоже ответственны за положительное влияние флавоноидов на сердце и сосуды. К ним относится ингибирование АФК-образующих ферментов, функции тромбоцитов, активации лейкоцитов и сосудорасширяющее действие.

Среди многочисленных эффектов флавоноидов, обнаруженных в экспериментах in vitro и in vivo, наиболее важны:

  • Противоаллергические и противовоспалительные,
  • Противомикробные,
  • Антиоксидантные,
  • Антипролиферативные и антиканцерогенные.

Флавоноиды обладают несколькими механизмами действия. На переднем плане – взаимодействие с ДНК и ферментами, активация клеток, влияние на различные пути передачи сигналов в клетках (NF-κB, MAPK). Флавоноиды ингибируют более тридцати ферментов в организме человека. Они активируют различные типы клеток иммунной системы. Последние два свойства отвечают за противовоспалительное действие флавоноидов.

Следующие флавоноиды используются в качестве венотоников:

  • Гесперидин,
  • Диосмин,
  • Рутин и гидроксиметилрутинозиды.

Среди препаратов преобладают те, которые содержат флавонольные гликозиды и гликозильные флавоны. Важные лекарственные средства, которые содержат большее количество флавоноидов:

  • Цветы арники,
  • Березовые листья,
  • Трава гречихи,
  • Листья гинкго,
  • Хмель,
  • Цветки ромашки,
  • Котовник обыкновенный,
  • Экстракт лиственницы,
  • Расторопша,
  • Трава пассифлоры,
  • Горькая апельсиновая корка,
  • Листья красного винограда,
  • Цветы сафлоры,
  • Анютины глазки,
  • Корень солодки,
  • Листья и цветы боярышника.

Сравнительный анализ двух препаратов

Многие спрашивают, Флебодиа или Детралекс – что лучше при геморрое? Детралекс от Флебодии отличается наличием геспередина в составе. Поэтому он считается более эффективным препаратом. В остальном действующие вещества двух препаратов не отличаются по фармакодинамике и фармакокинетике.

Дозировка

При остром геморрое рекомендуется пить 2-3 таблетки Флебодии или Детралекса ежедневно. Лекарственные средства рекомендуется принимать во время пищи в течение 1 недели. При неэффективности медикаментозной терапии требуется обратиться к врачу. Детралекс

Преимущества препаратов

Как и все полифенолы, флавоноиды обладают чрезвычайно сильными антиоксидантами свойствами, которые захватывают практически все свободные радикалы в организме. Свободные радикалы представляют собой чрезвычайно реакционноспособные соединения, которые инициируются, например, интенсивным солнечным светом. Прежде чем такие соединения повредят липиды, белки или ДНК, флавоноиды дезактивируют высокореактивные молекулы азота и кислорода, препятствуя окислению.

Антиоксидантными свойствами обладают продукты богатые витаминами С и Е. Флавоноиды обладают и определенным противомикробным действием. Например, зеленый чай содержит эпигаллокатехин, который нарушает клеточную мембрану бактерий. Некоторые заявляют, что данные вещества обладают специфическим противовирусным действием, однако это не было доказано ни в одном клиническом исследовании.

Другим важным эффектом флавоноидов считается иммуносупрессия (подавляет иммунологические процессы) и ингибирование воспаления. Эти вещества оказывают поддерживающее действие на сердце, поскольку компенсируют артериальное давление в определенном диапазоне и, таким образом, снижают риск тромбоза.

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Диосмин и геспередин относятся к флавоноидам, желтым пигментам с кольцевой структурой бензопирона, которые встречаются в разных растениях. В экспериментальных условиях они уменьшают капиллярную проницаемость и улучшают микрососудистую перфузию, возможно, путем ингибирования агрегации эритроцитов. Были доказаны антиоксидантные эффекты и сродство к стенке вен. Гидроксиэтилрутозиды, полусинтетические производные рутинов, чаще всего используются в медицинских целях.

Наиболее часто используемая смесь – оксерутин, одна фракция которого называется троксерутином. Поглощение оксерутина из желудочно-кишечного тракта относительно невелико и составляет 10%. Конечный период полураспада в плазме составляет 10-25 часов. Гидроксиэтилрутозиды, вероятно, метаболизируются в печени.

Оксерутин используется для наружной терапии геморроидальных заболеваний. Диосмин – один из эффективных флавоноидов, применяемых в медицине

Эффективность комбинации (гесперидин + диосмин) изучалась в нескольких исследованиях у лиц с хронической венозной недостаточностью (ХВН). В одном недавнем исследовании 133 пациента с ХВН II степени (отек, флебэктазия и незначительные поражения) использовали компрессионные чулки 2 класса. Вместе с этим они получали комбинированный препарат в течение 12 недель (3 таблетки два раза в день) или плацебо.

В группе, получившей лечение комбинированным препаратом, объемы ног уменьшились значительно больше, чем в группе плацебо (минус 64 мл против минус 33 мл). Симптомы (тяжелые, уставшие ноги, стеснение, покалывание) не показали никакой разницы. Несколько более старых исследований показали значительно большее снижение отеков, боли, судорог или синдрома тяжелых и беспокойных ног при использовании гидроксиэтилрутозидов по сравнению с плацебо.

При сравнении терапии различных галеновых препаратов (покрытых оболочкой таблеток, капсул, водных растворов) все препараты с диосмином были сопоставимы по эффективности и превосходили плацебо. Напротив, в мини-исследовании у 12 пациентов с 1 таблеткой препарата объем ног в значительной степени не уменьшился.

Малоубедительны результаты лечения венозных язв. Хотя отдельные исследования показали более высокую скорость лечения, чем плацебо, статистическая значимость не была выявлена. Отрицательный результат получен и в исследовании 120 человек, в котором флавоноиды использовались для предотвращения рецидива болезни. В течение 3 месяцев 32% рецидивировали с плацебо, 34% – с флавоноидами. Гесперидин

В 1970-х годах флавоноиды изучались у беременных женщин с варикозными расстройствами. В плацебо-контролируемом исследовании у 69 женщин отмечалось значительное влияние на симптомы (особенно уставшие ноги и судороги) и окружность голеностопного сустава.

Желудочно-кишечные жалобы, головная боль, головокружение и зуд были наиболее частыми побочными эффектами в исследованиях. Однако они встречались так же часто, как в группе плацебо. Сегодня использовать флавоноиды при беременности крайне не рекомендуется.

Известно, что одновременное введение с пероральным антикоагулянтом варфарином не приводит к существенному взаимодействию.

Контролируемые клинические исследования с применением внешних венозных препаратов проводятся редко. Было доказано, что поверхностный тромбофлебит реагирует на лечение гепарином или флавоноидами. Гель, содержащий 5% гесперидина, использовался в новом плацебо-контролируемом исследовании для предотвращения дискомфорта во время длительного полета. Были обследованы 57 человек, которые ранее страдали от венозных жалоб, но не имели более сильной ХВН. Гель втирали 2 раза в первый час, а затем каждые 3-4 часа. Исследования показали, что гель с флавоноидами уменьшал болезненные симптомы. ХВН – показание к назначению флавоноидов

При применении внешних препаратов часто возникает крапивница. Это относится и к лекарственным средствам, отпускаемым по рецепту, и к безрецептурным мазям и кремам. Поскольку риск сенсибилизации особенно высок, когда внешние факторы используются вблизи дефектов кожи, пациенты с язвами ног не должны применять данные медикаментозные средства.

В целом, преимущества флавоноидов скромны, и ни одно из веществ не влияет на течение болезни. Сегодня известно, что они не оказывают существенного лечебного эффекта. Для ряда пероральных венозных препаратов симптоматическая польза контексте ХВН может считаться достаточно документированной. Это относится, в частности, к экстрактам конского каштана, гесперидину, диосмину и кальциевому добесилату.

О серьезных побочных эффектах не сообщалось, за исключением кальция добесилата. Недостатком флавоноидов считаются в значительной степени неизученные метаболические пути в организме человека. Иногда могут возникать непредсказуемы реакции, которые приводят к летальному исходу. Временное введение пероральных венотоников оправдано, если другие виды лечения не дали необходимого эффекта. При язвах ног требуется принимать ацетилсалициловую кислоту, а не венотоники.

Эффективность флавоноидов при геморрое изучалась только в нескольких одноцентровых исследованиях. Было показано, что они ускоряют регенеративные и восстановительные процессы. Клинический эффект отмечен только при первой и второй стадии геморроя.

В клинических исследованиях были подтверждены противовоспалительные и антиаллергические свойства флавоноидов. Это связано с тем, что ряд этих веществ способен ингибировать ферменты, активировать клетки, которые регулируют иммунные реакции.

Исследование, проведенное Университетом Далхаузи в Канаде, показало, что флавоноиды из экстракта кожуры яблока обладают таким же эффектом снижения артериального давления, как и ингибиторы АПФ. Однако отмечено было, что препараты оказывают двойственный эффект. У некоторых пациентов прием флавоноидов повышает давление.

Неоспорим предотвращающий рак эффект флавоноидов. По данным Немецкого онкологического общества (НОО), в более чем 250 исследованиях было доказано, что обширное потребление фруктов и овощей снижает риск развития злокачественных новообразований.

Исследования показали, что у французских мужчин значительно меньше риск артериосклеротических изменений, чем у американцев, хотя они едят гораздо больше жира, чаще курят. Это явление называют «французским парадокс» и связано с антиоксидантным эффектом. Дальнейшие исследования показали, что флавоноиды оказывают антиоксидантное действие и на ЛПНП – липопротеины низкой плотности. В результате ЛПНП может быстро прилипать к стенкам сосуда и приводить к артериосклеротическим изменениям.

Побочные эффекты флавоноидов

О полезных свойствах флавоноидов стало известно только недавно. Как упоминалось выше, их положительный эффект не полностью доказан. Однако они не вредят людям в рамках исследований. Из-за этого данные вещества используются в медикаментах, особенно в качестве печеночной терапии и диуретиков (мочегонных средств.).

Побочные реакции, которые вызывают флавоноиды:

  • Головокружение,
  • Боли неясного генеза,
  • Тошнота (при пероральном введении),
  • Рвота.

Тошнота – частая побочная реакция

Противопоказания к использованию флавоноидов

Главные противопоказания к применению:

  • Гемофилия или другие нарушения свертываемости крови,
  • Гиперчувствительность,
  • Первый триместр беременности.

Препараты с флавоноидами обладают незначительным количеством побочных действий и противопоказаний. Однако использовать концентрированные средства допустимо только по назначению врача.

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