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Торговое название препарата: Бромгексин 8 Берлин-Хеми
Международное непатентованное название: Бромгексин
Лекарственная форма: драже
Состав на 1 драже:
Действующее вещество: бромгексина гидрохлорид – 8,000 мг.
Вспомогательные вещества: лактозы моногидрат – 34,400 мг, крахмал кукурузный – 14,600 мг, желатин – 1,800 мг, кремния диоксид коллоидный – 0,600 мг, магния стеарат – 0,600 мг;
Оболочка: сахароза – 27,704 мг, кальция карбонат – 4,326 мг, магния карбонат – 1,507 мг, тальк –1,507 мг, макрогол 6000 – 1,750 мг, глюкозный сироп – 1,639 мг, титана диоксид (Е 171) – 1,166 мг, повидон К 25 – 0,243 мг, воск карнаубский – 0,012 мг, хинолиновый желтый (Е 104) – 0,146 мг.
Описание: драже от желтого до зеленовато-желтого цвета двояковыпуклой формы с почти белым ядром.
Фармакотерапевтическая группа: Отхаркивающее муколитическое средство.
АТХ: R05СВ02.
Фармакологические свойства
Фармакодинамика
Бромгексин 8 Берлин-Хеми оказывает муколитическое (секретолитическое) и отхаркивающее (секретомоторное) действие, а также слабое противокашлевое действие. Снижает вязкость мокроты, активирует мерцательный эпителий, увеличивает объем мокроты и улучшает ее отхождение. Стимулирует выработку эндогенного сурфактанта, обеспечивающего стабильность альвеолярных клеток в процессе дыхания. Эффект проявляется через 2-5 дней от начала лечения.
Фармакокинетика
При приеме внутрь практически полностью (99%) всасывается в желудочно-кишечном тракте (ЖКТ) в течение 30 мин. Биодоступность составляет около 80%. Связывается с белками плазмы на 99%. Проникает через плацентарный и гематоэнцефалический барьеры. Проникает в грудное молоко. В печени подвергается деметилированию и окислению, метаболизируется до амброксола. Период полувыведения равен 15 ч (вследствие медленной обратной диффузии из тканей). Выводится почками в виде метаболитов. При хронической почечной недостаточности (ХПН) нарушается выделение метаболитов. При многократном применении может кумулировать.
Показания к применению
— острые и хронические бронхолегочные заболевания, сопровождающиеся образованием мокроты повышенной вязкости (бронхиальная астма, пневмония, трахеобронхит, обструктивный бронхит, бронхоэктазы, эмфизема легких, муковисцидоз, туберкулез, пневмокониоз).
— повышенная чувствительность к бромгексину и другим компонентам препарата;
— дефицит лактазы, непереносимость лактозы, глюкозо-галактозная мальабсорбция;
— язвенная болезнь желудка и двенадцатиперстной кишки (в стадии обострения);
— беременность (I триместр);
— детский возраст до 6 лет.
С осторожностью
— почечная и/или печеночная недостаточность;
— при нарушении моторики бронхов, сопровождающемся чрезмерным скоплением секрета;
— при склонности к желудочным кровотечениям в анамнезе.
Применение при беременности и в период лактации
Применение препарата во время беременности возможно только в том случае, если предполагаемая польза для матери превышает возможный риск для плода. Применение препарата в период лактации противопоказано.
Способ применения и дозы
Препарат назначают внутрь, после еды, не разжевывая, запивая достаточным количеством жидкости.
Для взрослых и подростков старше 14 лет: 3 раза в сутки по 1-2 драже (24-48 мг/сутки).
Дети от 6 до 14 лет, а также пациенты с массой тела менее 50 кг: принимают 3 раза в сутки по 1 драже (24 мг/сутки).
При нарушении функции почек и/или печени следует увеличить интервалы между приемами, либо уменьшить дозу. По данному вопросу необходимо проконсультироваться с лечащим врачом.
Длительность применения устанавливается в индивидуальном порядке и зависит от показаний и течения болезни. При необходимости приема более 4-5 дней требуется консультация врача.
Обычно Бромгексин 8 Берлин-Хеми переносится хорошо.
В редких случаях возможны тошнота, рвота, диспепсические явления, обострение язвенной болезни желудка и двенадцатиперстной кишки, аллергические реакции (кожная сыпь, ринит, отеки), одышка, повышение температуры тела и озноб.
Головная боль, головокружение.
Повышение активности «печеночных » трансаминаз (крайне редко).
При всех формах аллергических реакций необходимо прекратить прием данного лекарственного средства и проинформировать об этом врача.
Передозировка
Опасные для жизни последствия передозировки, при применении Бромгексин 8 Берлин-Хеми, неизвестны.
Возможны следующие симптомы: тошнота, рвота, диарея, диспепсические расстройства.
Лечение: искусственная рвота, промывание желудка в первые 1-2 часа после приема препарата.
По причине высокой степени связывания с белками и высокого объема распределения элиминация бромгексина при гемодиализе или форсированном диурезе не происходит.
Взаимодействие с другими лекарственными средствами
Бромгексин не назначают одновременно с лекарственными средствами, подавляющими кашлевой центр (в том числе содержащими кодеин), т.к. это затрудняет эвакуацию разжиженной мокроты.
Бромгексин способствует проникновению антибиотиков (эритромицин, цефалексин, окситетрациклин, ампициллин, амоксициллин) в бронхиальный секрет в первые 4-5 дней противомикробной терапии.
Не совместим со щелочными растворами.
Особые указания
В случаях нарушения моторики бронхов или при значительном объеме выделяемой мокроты, применение препарата Бромгексин 8 Берлин-Хеми требует осторожности, в связи с риском задержки отделяемого в дыхательных путях.
В процессе лечения рекомендуется употреблять достаточное количество жидкости, что повышает секретолитическое действие бромгексина.
При тяжелой почечной недостаточности необходимо учитывать возможность кумуляции образующихся в печени метаболитов.
У детей лечение следует сочетать с постуральным дренажем или вибрационным массажем грудной клетки, облегчающим выведение секрета из бронхов.
Влияние препарата на способность к вождению автотранспорта и управлению механизмами
В период лечения необходимо соблюдать осторожность при управлении транспортными средствами и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Форма выпуска
По 25 драже в контурную ячейковую упаковку (блистер ПВХ/фольга алюминиевая).
По 1 блистеру вместе с инструкцией по применению в картонную пачку.
Условия хранения
Лекарственное средство хранить при температуре не выше 25°С.
Лекарственное средство хранить в недоступном для детей месте!
Срок годности
Не использовать по истечении срока годности, указанного на упаковке!
Условия отпуска из аптек
Владелец регистрационного удостоверения
Берлин-Хеми/Менарини Фарма ГмбХ, Германия
Фирма-производитель:
Темпельхофер Вег 83
12347 Берлин, Германия
Адрес для предъявления претензий:
123317 Москва, Пресненская набережная, д. 10, БЦ "Башня на Набережной", Блок Б
Бромгексин 4мг/5мл 100мл сироп
Фармстандарт ОТС (Россия) Препарат: Бромгексин
Бромгексин 8мг 20 шт. таблетки
Оболенское ФПО (Россия) Препарат: Бромгексин
Бромгексин 8мг 28 шт. таблетки
Обновление (Россия) Препарат: Бромгексин
Бромгексин 4мг/5мл 60мл микстура
Берлин Хеми (Германия) Препарат: Бромгексин
Бромгексин 8мг 25 шт. драже
Берлин Хеми (Германия) Препарат: Бромгексин
Бромгексин 8мг 50 шт. таблетки
Бромгексин 8мг 20мл капли
Кревель Мойзельбах ГмбХ (Германия) Препарат: Бромгексин
Бромгексин 8мг 20 шт. таблетки
Фармстандарт ОТС (Россия) Препарат: Бромгексин
Бромгексин 8мг 20 шт. таблетки
Озон (Россия) Препарат: Бромгексин
Бромгексин 4мг/5мл 60мл раствор для приема внутрь
Атолл ООО (Россия) Препарат: Бромгексин
Бромгексин 8мг 50 шт. таблетки
Озон (Россия) Препарат: Бромгексин
Бромгексин 4мг/5мл 100мл сироп
РОЗЛЕКС ФАРМ ООО (Россия) Препарат: Бромгексин
Бромгексин 4мг 50 шт. таблетки [для детей]
Атолл ООО (Россия) Препарат: Бромгексин
Бромгексин 8мг/мл 20мл капли для приема внутрь
Тульская ФФ (Россия) Препарат: Бромгексин
Бромгексин-гриндекс 4мг/5мл 100мл сироп
Бромгексин- акрихин 4мг/5мл 100мл сироп
Бромгексин- акрихин 8мг 20 шт. таблетки
Бромгексин никомед 8мг 150мл микстура никомед австрия гмбх
Бромгексин-гриндекс 4мг 50 шт. таблетки для детей
Бромгексин мс 8мг 50 шт. таблетки
Медисорб (Россия) Препарат: Бромгексин мс
Бромгексин- акрихин 4мг 50 шт. таблетки
Аналоги по действующему веществу
Бромгексин-гриндекс 4мг/5мл 100мл сироп
Бромгексин- акрихин 8мг 20 шт. таблетки
Бромгексин никомед 8мг 150мл микстура никомед австрия гмбх
Бромгексин мс 8мг 50 шт. таблетки
Медисорб (Россия) Препарат: Бромгексин мс
Бромгексин- акрихин 4мг 50 шт. таблетки
Аналоги из категории Препараты для лечения кашля
Ацц лонг 600мг 10 шт. таблетки шипучие
Сандоз (Германия) Препарат: Ацц
Ацц лонг 600мг 20 шт. таблетки шипучие
Сандоз (Словения) Препарат: Ацц лонг
Бромгексин- акрихин 4мг/5мл 100мл сироп
Амбробене 30мг 20 шт. таблетки
Ратиофарм (Германия) Препарат: Амбробене
Амброгексал 30мг 20 шт. таблетки salutas pharma
Сандоз (Германия) Препарат: Амброгексал
Аналоги из категории Противовирусные препараты от гриппа и простуды
Бромгексин- акрихин 8мг 20 шт. таблетки
Амбробене 15мг/2мл 2мл 5 шт. раствор для внутривенного введения
Тева (Германия) Препарат: Амбробене
Амброгексал 7,5мг/мл 50мл раствор для приема внутрь и ингаляций
Иннбиотех (Германия) Препарат: Амброгексал
Амброксол 30мг 20 шт. таблетки
Озон (Россия) Препарат: Амброксол
Геделикс 50мл капли
Кревель Мойзельбах ГмбХ (Германия) Препарат: Геделикс
Инструкция по применению Бромгексин
Состав и форма выпуска
Раствор для приема внутрь — 5 мл / 100 мл:
- Активное вещество: бромгексина гидрохлорид — 4 мг / 80 мг;
- Вспомогательные вещества: пропиленгликоль — 25 г, сорбитол — 40 г, концентрат ароматического вещества с запахом абрикоса — 0.05 г, хлористоводородная кислота 0.1М (3.5% раствор) — 0.156 г, вода очищенная — 49.062 г.
60 / 100 мл — флаконы темного стекла в комплекте с мерной ложкой — пачки картонные.
- Активное вещество: бромгексина гидрохлорид — 8 мг;
- Вспомогательные вещества: лактозы моногидрат — 34.4 мг, крахмал кукурузный — 14.6 мг, желатин — 1.8 мг, кремния диоксид коллоидный — 0.6 мг, магния стеарат — 0.6 мг.
- Состав оболочки: сахароза — 27.704 мг, кальция карбонат — 4.326 мг, магния карбонат — 1.507 мг, тальк — 1.507 мг, макрогол 6000 — 1.75 мг, повидон К25 — 0.243 мг, глюкозный сироп — 1.639 мг, карнаубский воск — 0.012 мг, титана диоксид (Е171) — 1.166 мг, хинолиновый желтый (Е104) — 0.146 мг.
25 шт. — блистеры — пачки картонные.
Раствор для приема внутрь прозрачный, бесцветный, слегка вязкий, с характерным абрикосовым запахом. Драже от желтого до зеленовато-желтого цвета двояковыпуклой формы с почти белым ядром.
Муколитическое средство с отхаркивающим действием. Снижает вязкость бронхиального секрета за счет деполяризации содержащихся в нем кислых полисахаридов и стимуляции секреторных клеток слизистой оболочки бронхов, вырабатывающих секрет, содержащий нейтральные полисахариды. Полагают, что бромгексин способствует образованию сурфактанта.
Бромгексин быстро всасывается из ЖКТ и подвергается интенсивному метаболизму при "первом прохождении" через печень. Биодоступность составляет около 20%. У здоровых пациентов Cmax в плазме определяется через 1 ч.
Широко распределяется в тканях организма. Около 85-90% выводится с мочой главным образом в форме метаболитов. Метаболитом бромгексина является амброксол.
Связывание бромгексина с белками плазмы высокое. T1/2 в терминальной фазе составляет около 12 ч.
Бромгексин проникает через ГЭБ. В небольших количествах проникает через плацентарный барьер.
Только небольшие количества выводятся с мочой с T1/2 6.5 ч.
Клиренс бромгексина или его метаболитов может уменьшаться у пациентов с тяжелыми нарушениями функции печени и почек.
Муколитический и отхаркивающий препарат.
Показания к применению Бромгексин
Заболевания дыхательных путей, сопровождающиеся образованием трудноотделяемого вязкого секрета: трахеобронхит, хронический бронхит с бронхообструктивным компонентом, бронхиальная астма, муковисцидоз, хроническая пневмония.
Противопоказания к применению Бромгексин
Повышенная чувствительность к бромгексину.
Бромгексин Применение при беременности и детям
При беременности и лактации бромгексин применяют в случаях, когда предполагаемая польза для матери превышает потенциальный риск для плода или ребенка.
Бромгексин Побочные действия
Со стороны пищеварительной системы: диспептические явления, транзиторное повышение активности печеночных трансаминаз в сыворотке крови.
Со стороны ЦНС: головная боль, головокружение.
Дерматологические реакции: повышенное потоотделение, кожная сыпь.
Со стороны дыхательной системы: кашель, бронхоспазм.
Бромгексин несовместим со щелочными растворами.
Дозировка Бромгексин
Способ применения и режим дозирования конкретного препарата зависят от его формы выпуска и других факторов. Оптимальный режим дозирования определяет врач. Следует строго соблюдать соответствие используемой лекарственной формы конкретного препарата показаниям к применению и режиму дозирования.
Внутрь взрослым и детям старше 10 лет — по 8 мг 3-4 раза/сут. Детям в возрасте до 2 лет — по 2 мг 3 раза/сут; в возрасте от 2 до 6 лет — по 4 мг 3 раза/сут; в возрасте от 6 до 10 лет — по 6-8 мг 3 раза/сут. При необходимости доза может быть увеличена взрослым до 16 мг 4 раза/сут, детям — до 16 мг 2 раза/сут.
В виде ингаляций взрослым — по 8 мг, детям старше 10 лет — по 4 мг, в возрасте 6-10 лет — по 2 мг. В возрасте до 6 лет — применяют в дозах до 2 мг. Ингаляции проводят 2 раза/сут.
Терапевтическое действие может проявиться на 4-6 день лечения. Парентеральное введение рекомендуется для лечения в тяжелых случаях, а также в послеоперационном периоде для предупреждения скопления густой мокроты в бронхах. Вводят по 2 мг п/к, в/м или в/в 2-3 раза/сут медленно в течение 2-3 мин.
При язвенной болезни желудка, а также при указаниях на желудочное кровотечение в анамнезе бромгексин следует применять под контролем врача.
С осторожностью применять у пациентов, страдающих бронхиальной астмой.
Бромгексин не применяют одновременно с лекарственными средствами, содержащими кодеин, т.к. это затрудняет откашливание разжиженной мокроты.
Применяют в составе комбинированных препаратов растительного происхождения с эфирными маслами (в т.ч. с маслом эвкалипта, маслом аниса, маслом мяты перечной, ментолом).
Бромгексин 8 Берлин-Хеми — это отхаркивающий лекарственный препарат, обладающий выраженным муколитическим действием, применяемый для лечения заболеваний, сопровождаемых наличием трудноотделимой мокроты.
Бромгексин от кашля содержит активное вещество бромгексина гидрохлорид. Его принцип действия основан на способности снижать вязкость густой мокроты за счет деполяризации кислых сахаридов, содержащихся в ней.
В этой статье мы рассмотрим для чего врачи назначают Бромгексин 8 Берлин-Хеми, в том числе инструкцию по применению, аналоги и цены на это лекарственное средство в аптеках. Реальные ОТЗЫВЫ людей которые уже воспользовались Бромгексин 8 Берлин-Хеми можно прочитать в комментариях.
Состав и форма выпуска
Препарат Бромгексин 8 Берлин-Хеми производится в виде двояковыпуклых драже жёлтого или слегка зеленоватого оттенка. На разломе должна визуализироваться двухслойная структура лекарства. Поставляется в упаковках по 20 и 25 штук. Для приобретения препарата не требуется рецепт врача.
- Действующее вещество: бромгексина гидрохлорид – 8,000 мг.
- Вспомогательные вещества: лактозы моногидрат – 34,400 мг, крахмал кукурузный – 14,600 мг, желатин – 1,800 мг, кремния диоксид коллоидный – 0,600 мг, магния стеарат – 0,600 мг.
Фармакологическое действие: секретолитическое (муколитическое), секретомоторное (отхаркивающее).
Показания к применению
Лекарственный препарат должен назначаться при таких болезненных состояниях:
- заболевания бронхов, а также легких, которые протекают как в хронической, так и в острой форме;
- образование в бронхах мокроты, которая имеют трудноотделяемую консистенцию и плохо выводится из организма.
Фармакологическое действие
Муколитическое (секретолитическое) средство, оказывает отхаркивающее и слабое противокашлевое действие.
Снижает вязкость мокроты (деполимеризует мукопротеиновые и мукополисахаридные волокна, увеличивает серозный компонент бронхиального секрета), активирует мерцательный эпителий, увеличивает объем и улучшает отхождение мокроты.
Стимулирует выработку эндогенного сурфактанта, обеспечивающего стабильность альвеолярных клеток в процессе дыхания. Эффект проявляется через 2-5 дней от начала лечения.
Инструкция по применению
Согласно инструкции по применению Бромгексин 8 Берлин-Хеми в виде драже следует принимать только после пищи, при этом запивая их достаточным объемом жидкости.
- Внутрь взрослым и детям старше 10 лет – по 8 мг 3-4 раза/сут. Детям в возрасте до 2 лет – по 2 мг 3 раза/сут; в возрасте от 2 до 6 лет – по 4 мг 3 раза/сут; в возрасте от 6 до 10 лет – по 6-8 мг 3 раза/сут. При необходимости доза может быть увеличена взрослым до 16 мг 4 раза/сут, детям – до 16 мг 2 раза/сут.
- В виде ингаляций взрослым – по 8 мг, детям старше 10 лет – по 4 мг, в возрасте 6-10 лет – по 2 мг. В возрасте до 6 лет – применяют в дозах до 2 мг. Ингаляции проводят 2 раза/сут.
- Парентеральное введение рекомендуется для лечения в тяжелых случаях, а также в послеоперационном периоде для предупреждения скопления густой мокроты в бронхах. Вводят по 2 мг п/к, в/м или в/в 2-3 раза/сут медленно в течение 2-3 мин.
Без врачебной консультации не следует употреблять Бромгексин 8 Берлин-Хеми более 5 – дневного периода. Доза должна быть снижена, если в анамнезе пациента есть заболевания печени тяжелого характера или сбои в работе почек.
Противопоказания
Нельзя использовать препарат в таких случаях:
- Сильная чувствительность к веществам, которые в нем содержатся;
- Непереносимость лактозы или ее дефицит;
- Язвенное заболевание ЖКТ;
- Беременность на первом триместре;
- Дети в возрасте до 6 лет.
В период вынашивания ребенка Бромгексин могут назначать в том случае, если пациентка находится на втором или третьем триместре, и польза от препарата преобладает над возможными осложнениями по отношению к здоровью малыша. В период же кормления грудью такое лекарственное средство применять нельзя.
Побочные эффекты
В целом препарат неплохо переносится пациентами, но иногда на фоне приема лекарственного средства, развиваются следующие побочные эффекты:
- приступы тошноты, расстройство пищеварения, рвота;
- головные боли, головокружения;
- аллергические реакции.
Такие проявления обычно возникают при длительном приеме препарата и быстро проходят после его отмены. Иногда прием Бромгексина провоцирует обострение язвенных процессов в желудке и кишечнике, возникновение одышки, появление озноба,повышения температуры тела.
Аналоги Бромгексин 8 Берлин-Хеми
У препарата есть определенные аналог по механизму действия:
- Амбробене;
- АЦЦ;
- Ацестин;
- Либексин;
- Амброксол;
- Бронхоксол;
- Аскорил;
- Лазолван;
- Синупрет;
- Флюдитек;
- Флавамед;
- Флуимуцил;
- Халиксол и т.д.
Внимание: применение аналогов должно быть согласовано с лечащим врачом.
Средняя цена БРОМГЕКСИН 8 БЕРЛИН-ХЕМИ, драже в аптеках (Москва) 138 рублей.
Условия продажи
Препараты бромгексина разрешены к отпуску без предъявления рецепта.
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