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Аллопуринол мочегонное или нет

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17 августа 2019

На сегодняшний день препарат «Аллопуринол» является базисным (основным и патогенетически обоснованным) лекарственным средством, которое используется в комплексной терапии такого заболевания, как подагра. Каждый человек прежде чем попробовать что-то новое, пытается найти максимум полезной информации об этом. Поэтому предлагаем более подробно разобраться с тем, когда же стоит применять «Аллопуринол». Отзывы пациентов и врачей будут представлены в нашем материале, а также вы узнаете, чего стоит опасаться во время приема данного лекарственного средства.

Фармакологическая характеристика препарата

«Аллопуринол» относится к группе противоподагрических препаратов. Основные действующие вещества – аллопуринол и активный его метаболит оксипуринол. Их фармакодинамические эффекты обусловлены нарушением синтеза мочевой кислоты с развитием уростатического эффекта. В конечном итоге это приводит к понижению ее концентрации с последующим растворением уратов.

За счет хорошей растворимости «Аллопуринол» обладает высокой биодоступностью. Препарат хорошо всасывается в просвете тонкого кишечника. В желудке в системный кровоток не попадает. Присутствие в плазме крови наблюдается уже спустя полчаса после приема, а максимальная концентрация отмечается через 1,5 часа. Соответственно, максимальная концентрация метаболита аллопуринола – оксипуринола, наблюдается через три часа после перорального приема.

Препарат обладает длительным периодом полувыведения и ввиду этого способен к кумуляции. У пациентов в начале терапии наблюдается повышение концентрации лекарственного средства, которое стабилизируется через одну-две недели терапии. За счет длительного выведения «Аллопуринол» (отзывы врачей это подтверждают) не рекомендуется к применению лицам с почечной недостаточностью. У пациентов с сохраненной выделительной функцией почек кумуляции не наблюдается.

«Аллопуринол»: показания к применению

Отзывы врачей, назначающих данный препарат, утверждают, что его применение наиболее эффективно и оправдано в случаях гиперурикемии (повышенное содержание мочевой кислоты в единице объема крови) при:

  • подагрическом артрите (подагре);
  • уратных заболеваниях мочеполовой сферы (нефропатии, мочекаменной болезни);
  • онкологических заболеваниях крови;
  • врожденных аномалиях ферментативной системы.

В отдельных случаях возможно назначение препарата детям для лечения уратной нефропатии, которая возникла на фоне терапии лейкемии, при врожденных заболеваниях, связанных с нарушением метаболизма мочевой кислоты, вторичной гиперурикемии различного происхождения.

Особенности применения препарата

Таблетки «Аллопуринол» (отзывы предупреждают о строгом соблюдении рекомендаций при приеме лекарства) принимаются после еды, их ни в коем случае нельзя разжевывать, а наоборот, их выпивают целиком и запивают как минимум стаканом теплой воды.

Людям, принимающим данное лекарство, всегда необходимо следить за своим питанием, и в случаях погрешности в диете обязательно корректировать его дозировку, но только под контролем своего лечащего специалиста.

Необходимая для лечения доза препарата «Аллопуринол» определяется в зависимости от содержания мочевой кислоты в кровяном русле. Как правило, она составляет от 100 до 300 мг на один прием препарата «Аллопуринол». Отзывы пациентов и врачей относительно такого дозирования положительные, так как лекарство принимается всего один раз в сутки.

Терапию подагры начинают с назначения 100 мг препарата один раз в день. В случае недостаточной эффективности и слабого снижения уровня мочевой кислоты дозировку постепенно повышают (на 100 мг каждые две-три недели), доводя до эффективной терапевтической под лабораторным контролем уровня мочевой кислоты. В таких случаях средняя дозировка и дальнейшая поддерживающая доза составляют от 200 до 400 мг, однако в отдельных ситуациях доза препарата может составлять до 800 мг. В таком случае ее разбивают на несколько раз в сутки.

При назначении препарата пациентам с почечной недостаточностью необходимо ориентироваться на клиренс креатинина.

Противопоказания к назначению «Аллопуринола»

Препарат противопоказан к применению пациентам с тяжелой степенью недостаточности функции почек, а также беременным и кормящим грудью. Также не рекомендуется назначать данное лекарственное средство пациентам, имеющим аллергические реакции или повышенную чувствительность к одному или нескольким компонентам препарата. Запрещено применение лекарственного средства у лиц, имеющих пограничное содержание мочевой кислоты в плазме крови, так как ее снижения с успехом можно добиться путем корректирования диеты.

«Аллопуринол»: побочные действия

Отзывы пациентов, которые использовали этот препарат впервые, свидетельствуют о том, что достаточно часто возможно обострение заболевания и усиление симптомов подагры с возникновением так называемых приступов. Но это явление кратковременное, и не стоит его опасаться настолько, чтобы прекращать терапию. А вот в случаях возникновения каких-либо высыпаний, дискомфортных ощущений или раннее отсутствующих признаков необходимо немедленно сообщить об этом врачу. При этом прием «Аллопуринола» необходимо немедленно прекратить, а по мере исчезновения симптоматики специалист может вновь назначить препарат, но в меньшей дозировке (начиная от 50 мг). Прием должен вестись под тщательным контролем лечащего врача и в условиях отделения.

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Среди побочных реакций со стороны нервной системы и высших психических функций возможно возникновение депрессии. Со стороны системы кроветворения редко наблюдается развитие угнетения функции костного мозга с возникновением тромбоцитопении, апластической анемии.

При приеме препарата возможно развитие метаболических нарушений в виде сахарного диабета, повышения уровня жирных кислот в плазме крови.

Со стороны сердечно-сосудистой системы возможно развитие артериальной гипертензии, брадикардии.

Частота возникновения побочных реакций на данное лекарственное средство увеличивается при наличии у пациента почечной недостаточности.

Форма выпуска и дозировка

«Аллопуринол» выпускается в таблетированной форме (по 30 или 50 шт. в упаковке) в дозировке 100 и 300 мг действующего вещества в одной таблетке. На отечественном рынке присутствует «Аллопуринол Сандоз 300». Отзывы о нем положительные, так как препарат в данной дозировке назначается всего один раз в сутки, что практически сводит на нет возможность пропустить прием лекарственного средства.

Отравление и передозировка препаратом

Отравления отмечаются крайне редко, однако известны случаи однократного приема 20 граммов препарата. При этом наблюдалась следующая симптоматика: головокружение, рвота, тошнота, диарея. При почечной недостаточности и продолжительном назначении больших доз лекарственного средства отмечались тяжелые симптомы интоксикации в виде лихорадки, гепатита, обострения почечной недостаточности.

Терапия острых отравлений и передозировки симптоматическая, направленная на ускоренное выведение лекарственного препарата из организма. Специфического антидота нет. Для скорейшего выведения препарата из организма эффективны диализные методы детоксикации.

Отзывы

Учитывая тот факт, что период накопления данного лекарственного вещества в крови (в достаточной концентрации для оказания терапевтического действия) составляет в среднем одну неделю, пациенты, страдающие подагрой, должны практически пожизненно применять «Аллопуринол». Отзывы медиков однозначны: препарат зарекомендовал себя хорошо. Но это не «чудо-таблетка», которую можно выпить и забыть о недуге. Подагра – это, скорее, образ жизни, а не хроническое заболевание. А вот именно «Аллопуринол» помогает контролировать уровень молочной кислоты и предотвращать обострение заболевания и его дальнейшее прогрессирование.

С точки зрения удобства назначения препарата «Аллопуринол» отзывы врачей также положительные, ведь пациенту в большинстве случаев необходимо однократно в сутки принимать лекарство. Это максимально снижает вероятность пропуска приема медикамента и, следовательно, повышает эффективность проводимой терапии.

Заключение

Таким образом, основное лекарство от подагры – «Аллопуринол». Отзывы специалистов и пациентов, принимающих данное средство, положительные, и это еще раз подтверждает эффективность использования медикамента при лечении подагры и нарушений обмена мочевой кислоты. Благодаря применению данного лекарственного средства, огромное количество пациентов приобретают надежду на снижение осложнений сахарного диабета.

Источником нарушения функции суставов ног может быть подагра. Часто терапевт дает направление к ревматологу, в специализацию которого входит лечение ревматических болезней сердца, соединительной ткани и суставов.

Подагра и артериальная гипертензия

Эти заболевания тесно связаны и возникают вследствие большого количества уратов в организме. Приступы подагры приводят к повышению давления и затрудняют протекание гипертонии. Исключено принимать мочегонные средства при подагре в случае, если необходимо понизить АД, так как действие таких средств влечет за собой подагрическое обострение.

Подагра возникает у людей с высоким уровнем мочевой кислоты (МК) в крови.

Повышенное артериальное давление способствует:

  • патологии сердечно-сосудистой системы;
  • инфарктам;
  • инсультам.

Появлению гипертонии содействует множество факторов:

  • дисфункция почек;
  • избыток веса;
  • сидячая работа;
  • нарушение режима приема пищи и неудовлетворительное ее качество;
  • курение;
  • алкоголь;
  • нервные и психические расстройства.

Причиной подагры является задержка мочевой кислоты в организме из-за сбоя процессов обмена. МК синтезируется печенью и поступает в кровь, поэтому не следует путать ее с мочой. Вследствие заболевания происходит отложение солей в суставной и мягкой тканях во всем теле человека, преимущественно там, где нарушено кровообращение.

Болевые ощущения чаще всего усиливаются ночью, когда кристаллы уратов аккумулируются в суставах и воспаляется область вокруг них. Через 3 дня все симптомы проходят, но возвращаются спустя полгода или год. Если не проводить лечение, то повторное проявление болезни может произойти раньше.

Выбор препарата при артериальной гипертензии

При назначении лекарства от данного заболевания следует учитывать тот факт, что неконтролируемое повышение АД приводит к инфаркту миокарда. После приступа человек страдает резкими перепадами давления, из-за чего надо регулярно стабилизировать состояние медицинскими препаратами.

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При борьбе с подагрой лечащий врач назначает комплексное лечение, подбирая медикаментозные средства, которые не повышают давление. Назначаются метаболически пассивные лекарственные средства: они не воздействуют на метаболизм и направлены на снижение уровня МК.

Можно ли применять диуретики при подагре

Прием только диуретиков не является гарантированным средством при рассматриваемом заболевании. Такие действия приведут к печальным последствиям. Нейтрализовать МК, вывести соли и избавиться от симптомов помогут соответствующие препараты.

Влияние мочегонных средств при подагре

Диуретические лекарства берут на себя функцию мочевой кислоты, которая выделяется почками и выводит из организма продукты распада. В данном случае вымываются другие средства, а количество МК в крови растет, т.е. начинается гиперурикемия, приближающая обострение подагры. Можно сделать вывод, что при данном недуге прием диуретиков опасен для здоровья.

Мочегонные препараты провоцируют обострение подагры, поэтому назначаются пациентам с этим заболеванием крайне редко, под контролем врача, только в тех случаях, когда другими лекарствами не удается адекватно снизить давление. Параллельно обязательно назначают медикаменты, снижающие синтез мочевой кислоты в организме.

Следствием приема диуретиков при данном заболевании являются:

  • провокация приступов артритов;
  • уплотнения под кожей — тофусы;
  • кисты, отображающиеся на рентгене.

Общие рекомендации при подагре

Для устранения патологии необходим длительный курс терапии протяженностью в несколько месяцев.

Благотворное влияние оказывают зеленый чай с жасмином, травы, улучшающие метаболизм (настой цветков ромашки, кукурузные рыльца и т.д.). При обострении симптомов подагры врач назначает курс лечения. Выздоровлению способствует лечебный комплекс упражнений и правильное питание, так как нарушения связаны с обменными процессами.

Характеристика препарата Амлодипин

Распространенное по всему миру средство от гипертонии является антагонистом Ca 3-го поколения. Оно снижает АД, способствует длительному сохранению низкого уровня давления. Побочные эффекты проявляются в легкой форме, что дает возможность сохранения постоянного АД на протяжении 24 часов.

Такое лекарство, как Амлодипин, при подагре нежелательно принимать пациентам в возрасте до 18 лет.

  • понижает давление, расширяя сосуды, действует стабильно и предсказуемо;
  • достаточно 1 приема в сутки;
  • продолжительность действия – 24-36 часов;
  • при нарушении режима употребления препарата риск резкого перепада АД отсутствует;
  • нейтрален для холестерина и глюкозы;
  • сохраняет частоту сердцебиения;
  • уменьшает вероятность появления инфаркта и инсульта;
  • не конфликтует с другими средствами от давления.

Использование Амлодипина показано людям:

  • с нарушением процесса пищеварения;
  • с гипертонической болезнью;
  • с диабетом;
  • в период после менопаузы;
  • от 60 лет;
  • страдающим ИБС: стабильной и вазоспастической стенокардией.

Препарат противопоказан лицам:

  • до 18 лет;
  • с тяжелой артериальной гипертензией;
  • перенесшим коллапс, кардиогенный шок;
  • после инфаркта;
  • с повышенной чувствительностью к компонентам препарата;
  • страдающим нестабильной стенокардией (кроме стенокардии Принцметала).

Побочными действиями являются отек конечностей, сердцебиение, одышка, прилив крови к лицу, тошнота и т.п.

Аналоги и заменители Амлодипина

  1. Лозартан – медицинский препарат, полностью абсорбирующийся через час из ЖКТ. При приеме наблюдается снижение АД в течение 6 часов, после чего 24 ч происходит постепенное снижение действия лекарственного средства. Максимальный эффект достигается через 3-6 недель. Основная часть препарата выводится через кишечник. У женщин с высоким АД содержание лозартана при подагре в крови в два раза выше, чем у мужчин, но концентрация активного метаболита одинакова.
  2. Фуросемид – сильнодействующее мочегонное средство, которое направлено на резкое и кратковременное увеличение объема мочи. В результате приема происходит интенсивное удаление ионов калия, кальция с жидкостью из организма. Показан при отечности. Исключено одновременное применение препарата с сердечными гликозидами. Противопоказан на начальных стадиях беременности, при почечной недостаточности, при нарушении водно-солевого обмена.
  3. Верошпирон – калийсберегающий мочегонный препарат длительного действия. Способствует сохранению ионов калия и мочевины, уменьшает кислотность мочи. Снижение АД вызывается мочегонным действием, наступающим на 2-5 день лечения. Показанием к применению является эссенциальная гипертония (в составе комбинированной терапии), гипокалиемия/гипомагниемия и пр.
  4. Эналаприл – антигипертензивный препарат из группы ингибиторов АПФ. Раздвигает стенки артерий в большей степени, чем вен. Показанием являются гипертензия и хроническая сердечная недостаточность. Помимо выраженного гипотензивного эффекта данное средство способно улучшить кровоток и предотвратить такие болезни, как подагрический артрит. Эналаприл можно принимать на ранних стадиях заболевания под контролем терапевта и ревматолога.

Вышеперечисленные средства являются препаратами, воздействующими на АД.

Необходимо учитывать, что любой медикамент обладает рядом противопоказаний и побочных действий. Самостоятельное лечение недопустимо, т.к. любое лекарство оказывает влияние на системы функционирования организма (ЖКТ, ЦНС, органы кроветворения, аллергические реакции, эндокринную, костно-мышечную ткань). При первых признаках патологии необходимо обратиться к лечащему врачу.

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Мочегонные средства при подагре

Медикаменты для лечения подагры делятся на угнетающие образование мочевой кислоты (урикодепрессивные средства), увеличивающие выведение уратов с мочой (урикозурические), обеспечивающие химический распад уратов (уриколитичсские).

Из гипоурикемических препаратов, для лечение подагры медикаментозно, наибольшее распространение получил аллопуринол. Аллопуринол не оказывает обезболивающего действия.

Аллопуринол — препарат выводящий мочевую кислоту при подагре

Лечение подагры медикаментами — снижение концентрации мочевой кислоты в сыворотке крови. По возможности необходимо отменить медикаменты диуретики при лечении подагры в домашних условиях. При сохранении концентрации мочевой кислоты в сыворотке крови выше 420 мкмоль/л и согласии больного на проведение длительного лечения подагры после третьего приступа артрита назначают аллопуринол. При наличии камней в почках, повышенном содержании креатинина в сыворотке крови лечение медикаментом аллопуринолом следует начать немедленно. Лечение должно быть непрерывным и длительным под контролем уровня мочевой кислоты в крови — целевой уровень менее 0,36-0,42 ммоль/л. Контроль уровня мочевой кислоты осуществляют через 1-2 мес. после начала лечения.

Для предотвращения обострения лечение подагры препаратом выводящий мочевую кислоту аллопуринолом до купирования приступа подагры начинать не следует. Начальная доза препарата небольшая — 100-150 мг/сут — с постепенным, в течение 2 нед, увеличением её до терапевтической — 300 мг/сут. Далее, при сохранении эффекта, дозу можно снизить вдвое. Если в течение 2 нед концентрация мочевой кислоты в сыворотке крови не снижается, дозу следует увеличить до 600 мг/сут. При ХПН (концентрация креатинина 160-560 мкмоль/л) дозу препарата уменьшают в 2 раза. При тяжёлой ХПН при лечении подагры эта доза обычно составляет 50-100 мг/сут. При подборе дозы учитывается, что эффект препарата достигается через 7-14 дней.

Приступы подагры при лечении подагры в домашних условиях могут повторяться ещё в течение 2-3 мес после начала лечения медикаментом аллопуринолом, в связи с чем назначают НПВП.

Наиболее частые побочные эффекты при лечении подагры препаратом выводящий мочевую кислоту: сыпь, нарушение функций печени. Редко отмечают угнетение функций костного мозга. Не следует назначать аллопуринол вместе с другим медикаментом, азатиоприном.

При бессимптомной гиперурикемии применение аллопуринола для лечения подагры неэффективно. При этом основным методом лечения служит диетотерапия.

После лечения подагры в течение 10-12 мес. у больных подагрическим артритом исчезает ощущение скованности, прекращаются острые приступы подагры, рассасываются мелкие и уменьшаются в размерах крупные тофусы, улучшается функция почек, могут исчезнуть мелкие конкременты в почках. Если у больного в течение 1 года отсутствовали острые атаки, исчезли тофусы, можно сделать перерыв в приеме медикаменты аллопуринола на 2-3 мес с последующим определением уровня урикемии. При обнаружении повышенного содержания мочевой кислоты лечение аллопуринолом должно быть продолжено. При правильно подобранной дозе препарата выводящего мочевую кислоту и практически постоянном приеме небольших доз этого препарата можно достигнуть полного исчезновения тофусов и подагрических атак в течение многих лет.

Урикозурические медикаменты выводящие мочевую кислоту при подагре

Урикозурические медикаменты (бензбромарон, бензйодарон, пробенецид и др.) способствуют выведению мочевой кислоты с мочой с уменьшением урикемии. Если нет гиперурикозурии (традиционная граница — 700 мг/сут), аллопуринол и урикозурические медикаменты показаны в равной степени. Известно мнение о предпочтительности назначения урикозурических средств пациентам в возрасте до 60 лет для лечения подагры в домашних условиях, при удовлетворительной функции почек и при отсутствии мочекаменной болезни.

Показания к применению урикозурических медикаментов при лечении приступов подагры: гиперурикемия, развившаяся в результате снижения экскреции мочевой кислоты почками ( тиазидные и тиазидоподобные диуретики . Их действие направлено на быстрый вывод вместе с мочой лишнего натрия. При нарушении функции почек у диабетиков взамен тиазидных диуретиков назначается Фуросемид, который относится к группе петлевых. Использовать его можно для одноразовой помощи. Калийсберегающие диуретики при сахарном диабете считаются малоэффективными и в лечении практически не применяются. Использовать их можно только при постоянном контроле общего состояния и под наблюдения врача, так как некоторые препараты могут понизить чувствительность клеток к инсулину.

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