Название препарата | Страна производитель | Действующее вещество (МНН) |
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Аленталь | Россия | Ацеклофенак |
Название препарата | Страна производитель | Действующее вещество (МНН) |
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Асинак | Индия | Ацеклофенак |
Название препарата | Форма выпуска | Цена (со скидкой) |
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Название препарата | Форма выпуска | Цена (со скидкой) |
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- Препараты
- Аэртал
Инструкция
- Владелец регистрационного удостоверения: Almirall, S.a. (Испания) Gedeon Richter, Plc. (Венгрия)
- Производитель: Gedeon Richter, Plc. (Венгрия) Industrias Farmaceuticas Almirall, S.l. (Испания)
- Представительство: Гедеон Рихтер ОАО (Венгрия)
Форма выпуска |
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Порошок для приготовления суспензии для приема внутрь, 100 мг: пак. 3 г 20 шт. |
Крем для наружного применения 1.5%: туба 60 г |
Таблетки, покрытые пленочной оболочкой, 100 мг: 10, 20, 30, 40, 60 или 90 шт. |
НПВС. Оказывает противовоспалительное, анальгезирующее и жаропонижающее действие. Угнетает синтез простагландинов и, таким образом, влияет на патогенез воспаления, возникновения боли и лихорадки.
При ревматических заболеваниях противовоспалительное и анальгезирующее действие ацеклофенака способствует значительному уменьшению выраженности боли, утренней скованности, припухлости суставов, что улучшает функциональное состояние пациента.
Быстро и полностью всасывается после приема внутрь. C max в плазме после приема внутрь достигается через 1.25-3 ч.
Связывание с альбуминами плазмы на 99%.
Проникает в синовиальную жидкость, где его концентрация достигает 57% от уровня концентрации в плазме и C max достигается на 2-4 часа позже, чем в плазме крови. V d — 25 л.
Подвергается метаболизму в незначительной степени. Основным его метаболитом, обнаруживаемым в плазме, является 4′-гидроксиацеклофенак.
T 1/2 — 4 ч. Выводится почками преимущественно в виде гидроксипроизводных (около 2/3 введенной дозы).
Купирование воспаления и болевого синдрома при:
— ревматическом поражении мягких тканей.
Взрослым назначают внутрь по 100 мг (1 таб.) 2 раза/сут утром и вечером.
Таблетки следует проглатывать целиком, запивая достаточным количеством жидкости.
Со стороны пищеварительной системы: тошнота, рвота, диарея, боли в области эпигастрия, кишечная колика, диспепсия, метеоризм, анорексия, запор, транзиторное повышение активности печеночных трансаминаз; редко — эрозивно-язвенные поражения, кровотечения и перфорации ЖКТ (гематемезис, мелена), стоматит (в т.ч. афтозный), панкреатит, гепатит; в отдельных случаях — фульминантный гепатит.
Со стороны нервной системы: иногда — головная боль, головокружение, нарушения сна (бессонница или сонливость), возбуждение; в отдельных случаях — нарушения чувствительности, дезориентация, нарушение памяти, зрения, слуха, вкусовых ощущений, шум в ушах, судороги, раздражительность, тремор, депрессия, тревожность, вертиго, асептический менингит, парестезия.
Аллергические реакции: иногда — кожная сыпь; редко — крапивница, бронхоспазм, системные анафилактические реакции; в отдельных случаях — экзема, многоформная эритема, эритродермия, васкулит, пневмонит, синдром Стивенса-Джонсона, синдром Лайелла, анафилактический шок.
Со стороны мочевыделительной системы: редко — периферические отеки; в отдельных случаях — острая почечная недостаточность, интерстициальный нефрит, нефротический синдром, гематурия, протеинурия.
Со стороны системы кроветворения: лейкопения; в отдельных случаях — тромбоцитопения, агранулоцитоз, гемолитическая анемия, апластическая анемия.
Со стороны сердечно-сосудистой системы: в единичных случаях — тахикардия, артериальная гипертензия, застойная сердечная недостаточность, ИБС.
— эрозивно-язвенные поражения ЖКТ в фазе обострения;
— желудочно-кишечное кровотечение или подозрение на него;
— указания в анамнезе на бронхоспазм, крапивницу, ринит после приема ацетилсалициловой кислоты или других НПВС (полный или неполный синдром непереносимости ацетилсалициловой кислоты — риносинусит, крапивница, полипы слизистой оболочки носа, бронхиальная астма);
— период после проведения аортокоронарного шунтирования;
— выраженная печеночная недостаточность или активное заболевание печени;
— нарушения кроветворения и коагуляции;
— выраженная почечная недостаточность, прогрессирующие заболевания почек;
— период лактации (грудное вскармливание);
— детский и подростковый возраст до 18 лет;
— повышенная чувствительность к компонентам препарата.
С осторожностью следует применять препарат при заболеваниях печени, почек и ЖКТ в анамнезе, бронхиальной астме, артериальной гипертензии, снижении ОЦК (в т.ч. сразу после обширных оперативных вмешательств), ИБС, хронической почечной, печеночной и сердечной недостаточности, при КК ® при беременности отсутствуют. Регулярное применение НПВС в III триместре беременности может приводить к снижению тонуса и более слабым сокращениям матки. Применение НПВС может приводить к преждевременному закрытию боталлова протока у плода и, возможно, к длительной легочной гипертензии у новорожденного, задержке начала родовой деятельности и увеличению продолжительности родов.
В эпидемиологических исследованиях у человека не было получено данных, указывающих эмбриотоксичность НПВС. Однако в экспериментальных исследованиях на кроликах при введении ацеклофенака (10 мг/кг/сут) в некоторых случаях наблюдались морфологические изменения у плода. Данные о наличии тератогенного эффекта у крыс отсутствуют.
Данные о выделении ацеклофенака с грудным молоком у человека отсутствуют. В экспериментальных исследованиях при введении радиоактивного 14 С-ацеклофенака лактирующим крысам заметного переноса радиоактивности в молоко не наблюдалось.
Противопоказан в детском и подростковом возрасте до 18 лет.
Симптомы: клиническая картина определяется нарушениями со стороны ЦНС (в т.ч. головная боль, головокружение, явления гипервентиляции с повышенной судорожной готовностью) и пищеварительной системы (в т.ч. боли в животе, тошнота, рвота).
Лечение: промывание желудка, прием внутрь активированного угля, симптоматическая терапия. Специфического антидота не существует. Форсированный диурез, гемодиализ, переливание крови малоэффективны.
При одновременном применении с препаратом Аэртал ® возможно повышение концентраций в плазме крови дигоксина, фенитоина, лития.
При одновременном применении с препаратом Аэртал ® возможно уменьшение эффективности диуретиков и антигипертензивных средств.
Одновременное применение калийсберегающих диуретиков и препарата Аэртал ® может привести к развитию гипергликемии и гиперкалиемии.
При одновременном приеме препарата Аэртал ® и ГКС или других НПВС повышается риск развития побочных эффектов со стороны пищеварительной системы.
При одновременном приеме препарата Аэртал ® и селективных ингибиторов обратного захвата серотонина (в т.ч. циталопрам, флуоксетин, пароксетин, сертралин) повышает риск развития кровотечения из ЖКТ.
Одновременный прием препарата Аэртал ® может повысить нефротоксическое действие циклоспорина.
На фоне одновременного приема Аэртала и гипогликемических препаратов возможно развитие как гипо-, так и гипергликемии (необходим контроль уровня глюкозы в крови).
Прием препарата Аэртал ® в течение 24 ч до или после применения метотрексата может привести к повышению концентрации метотрексата в плазме и к усилению его токсического действия.
При одновременном применении с ацетилсалициловой кислотой возможно снижение концентрации ацеклофенака в плазме крови.
При одновременном применении антиагрегантов и антикоагулянтов повышается риск развития кровотечений (необходим регулярный контроль показателей свертывания крови).
Препарат следует хранить в недоступном для детей месте при температуре не выше 25°С. Срок годности — 3 года.
С особой осторожностью следует назначать препарат пациентам с заболеваниями печени. Следует учитывать, что у пациентов с печеночной недостаточностью возможны изменения кинетики и метаболизма препарата.
Препарат противопоказана при выраженной печеночной недостаточности или активном заболевании печени.
С особой осторожностью следует назначать препарат пациентам с заболеваниями почек с хронической почечной недостаточностью.
Препарат противопоказана при выраженной почечной недостаточности, прогрессирующем заболевании почек, подтвержденной гиперкалиемии.
С осторожностью следует назначать препарат пациентам пожилого возраста.
В период лечения препаратом следует проводить систематический контроль картины периферической крови, функции печени, почек, исследование кала на наличие крови.
Из-за важной роли простагландинов в поддержании почечного кровотока следует проявлять особую осторожность при назначении пациентам с сердечной или почечной недостаточностью, пожилого возраста, принимающих диуретики, и больных со сниженным ОЦК (например, после обширного хирургического вмешательства). Если в таких случаях назначают ацеклофенак, рекомендуется контролировать функцию почек.
У пациентов с печеночной недостаточностью кинетика и метаболизм отличаются от аналогичных процессов у пациентов с нормальной функцией печени.
Для снижения риска развития нежелательных явлений со стороны ЖКТ следует использовать минимальную эффективную дозу минимально возможным коротким курсом.
Пациентам, принимающим препарат, необходимо воздерживаться от употребления алкоголя.
Влияние на способность к вождению автотранспорта и управлению механизмами
Пациентам, страдающим головокружениями и другими нарушениями со стороны ЦНС, в период приема препарата Аэртал ® необходимо воздерживаться от деятельности, требующей повышенной концентрации внимания и быстроты психомоторных реакций (вождения автотранспорта и работы с опасными механизмами).
Лекарственное средство аэртал испанского производства относится к противовоспалительным нестероидным препаратам на основе ацеклофенака. Медикамент является эффективным анальгетиком, практикуется его применение в качестве жаропонижающего лекарства.
Средние цены в аптеках 325–850 рублей.
Аэртал нельзя использовать при беременности, лактации, детям до 18 лет. Имеются другие противопоказания.
Существует много обезболивающих лекарств, с идентичным механизмом действия, но действующее вещество может различаться. Близкие заменители и дешёвые аналоги препарата часто выручают пациентов при невозможности лечиться аэрталом.
Аналоги российского производства
Таблица включает синонимы аэртала из числа нестероидных противовоспалительных препаратов от отечественного производителя.
Наименование препарата | Средняя цена в рублях | Характеристика |
Ацеклофенак | 175–190 | Самый дешёвый точный аналог аэртала отечественного выпуска, который входит в его состав, как главный активный компонент. |
Имеет идентичные показания и противопоказания, выпускается в таблетках.
В продаже имеется гель, суппозитории ректальные, таблетки, раствор для инъекций.
Применяется средство при заболеваниях суставов и опорно-двигательного аппарата, сопровождающихся болевым синдромом и воспалением.
Область применения включает лечение ревматоидного артрита, артропатии, артроза, бурсита, спондилита, тендинита, радикулопатии.
Украинские заменители
Аналоги аэртала украинского производства имеют другой состав лекарства, но одинаковые показания к применению.
Список содержит медикаменты, которые подскажут чем заменить препарат:
- Ревмоксикам. Лучший и дешёвый препарат для лечения ревматологических патологий и заболеваний суставов. В основе лекарства – мелоксикам. Средняя цена 110–245 рублей.
- Форт Гель. Нестероидное противовоспалительное средство с кетопрофеном в основе лекарства. Используется местно для устранения боли при ушибах, травмах, при ревматических заболеваниях. Средняя цена 55–70 рублей.
- Диклофенак Натрий. Недорогой украинский близкий заменитель аэртала с действующим веществом диклофенаком. Выпускается в виде мази, геля, крема, порошка для разведения, свечей, таблеток, суспензии.
Обезболивающий и противовоспалительный медикамент с жаропонижающей функцией. Средняя цена 20–110 рублей.
Белорусские дженерики
Следует рассмотреть современные белорусские дженерики аэртала, которые могут выступать как эффективная замена на дешёвый обезболивающий и противовоспалительный медикамент при ревматических и других заболеваниях.
Наименование препарата | Средняя цена в рублях | Характеристика |
Ацеклофенак Мик | 210–620 | Лучший белорусский синоним аэртала с аналогичным действующим веществом. |
Применяется при остеоартрите, ревматоидном артрите, анкилозирующем спондилоартрите, плечелопаточном периартрите, для снятия болевого синдрома.
Продаётся в капсулах.
Показания к применению: болезни суставов, ревматоидный артрит, болезнь Бехтерева.
Линейка медикамента включает различные формы выпуска от таблеток до порошков и суппозиториев.
Таблетки, гель или суспензия используется при лечении ревматических и суставных заболеваний, а также для снятия острого болевого синдрома.
Самый дешёвый синоним аэртала с одноимённым активным веществом.
Выпускается в таблетках, также можно найти гель, мазь, крем, порошок для приготовления инъекций, суспензию.
Препарат применяется для обезболивания, снижения температуры, в качестве противовоспалительного средства.
Можно использовать во 2,3 триместрах беременности, детям с 3 месяцев, при грудном вскармливании.
Прочие иностранные аналоги
Ниже представлены лучшие импортные лекарства из группы нестероидных противовоспалительных препаратов.
- Асинак. Медикамент применяется для лечения воспалительных заболеваний опорно-двигательного аппарата. Состав лекарства включает ацеклофенак. Страна производитель – Индия. Средняя цена 315–380 рублей.
- Ацеклон. Популярный аналог аэртала из категории лекарств с ацеклофенаком подешевле. Показания следующие: различные виды артрита, анкилозирующий спондилоартрит, подагра, остеоартроз. Препарат производят в Индии. Средняя цена 185–450 рублей.
- Зеродол. Таблетки с ацеклофенаком. Противоревматическое нестероидное средство, с противовоспалительной и жаропонижающей функцией. Страна производитель – Индия. Средняя цена 90–150 рублей.
- Вольтарен. Эмульгель на основе калиевой соли диклофенака, которая оказывает выраженное обезболивающее и противовоспалительное действие. Швейцарское лекарство с различной формой выпуска: гель, пластырь, мазь, таблетки, уколы в ампулах, свечи, спрей. Средняя цена 210–650 рублей.
- Мовалис. Лекарственное средство лечит артрозы, артриты и другие ревматологические заболевания опорно-двигательной системы и сосудов. Таблетки, уколы и суспензия содержат мелоксикам в основе. Медикамент выпускается в Греции, Германии, Австрии. Средняя цена 205–920 рублей.
- Нимесил. Один из лучших недорогих импортных аналогов аэртала с нимесулидом в основе. Имеется множество форм выпуска: крем, гель, таблетки, мазь, порошок для приготовления напитка, раствор для инъекций, суспензия, спрей, капли, свечи вагинальные и ректальные.
Средство итальянского или немецкого производства. Средняя цена 25–690 рублей.
Несмотря на свободный отпуск в аптеке, самостоятельный выбор лекарства не рекомендуется. Для того чтобы навсегда избавиться от боли и устранить не симптом заболевания, а его причину, нужно обратиться к врачу.
Из этой медицинской статьи можно ознакомиться с лекарственным препаратом Аэртал. Инструкция по применению пояснит, в каких случаях можно принимать лекарство, от чего оно помогает, какие существуют показания к применению, противопоказания и побочные эффекты. В аннотации представлены формы выпуска препарата и его состав.
В статье врачи и потребители могут оставлять только реальные отзывы про Аэртал, из которых можно узнать помогло ли лекарство в терапии люмбаго, ревматоидного артрита и артроза у взрослых и детей. В инструкции перечислены аналоги Аэртала, цены препарата в аптеках, а также его использование при беременности.
Нестероидным противовоспалительным препаратом является Аэртал. Инструкция по применению рекомендует принимать таблетки 100 мг, порошок для приготовления суспензии, крем или мазь для снятия воспаления, жара, боли при ревматизме, уменьшения скованности суставов по утрам и их припухлости.
Форма выпуска и состав
Лекарственные формы Аэртала:
- таблетки, покрытые пленочной оболочкой;
- порошок для изготовления суспензии для перорального применения;
- крем (мазь) для наружного применения: однородная субстанция белого цвета, которая реализуется в алюминиевых тубах по 60 г.
Активное вещество всех форм выпуска – ацеклофенак. В таблетке и пакетике порошка его содержание достигает 100 мг. В 1 г крема содержание действующего вещества – 15 мг.
Фармакологические свойства
Препарат оказывает эффективное анальгезирующее, противовоспалительное и жаропонижающее действие, благодаря угнетению синтеза простагландинов, что в свою очередь приводит к уменьшению воспаления, лихорадки и болевого синдрома. Особенно активен ацеклофенак при различных ревматических заболеваниях, он способствует снижению отечности суставов, утренней скованности и уменьшению выраженности суставной боли.
Активное вещество быстро и полностью всасывается после приема внутрь препарата Аэртал. Инструкция по применению (цена, отзывы, аналоги будут рассмотрены ниже) указывает, что связывание с альбуминами плазмы происходит на 99%. Проникает в синовиальную жидкость, где его концентрация достигает 57% от уровня концентрации в плазме. Подвергается метаболизму в незначительной степени.
Основным его метаболитом, обнаруживаемым в плазме, является 4′-гидроксиацеклофенак. Выводится почками преимущественно в виде гидроксипроизводных (около 2/3 введенной дозы).
От чего помогает Аэртал?
Показания к применению лекарства включают:
- плечелопаточный периартрит;
- люмбаго;
- зубная боль;
- ревматоидный артрит;
- анкилозирующий спондилит;
- ревматизм мягких тканей;
- остеоартроз;
- другие заболевания опорно-двигательного аппарата.
Инструкция по применению
Таблетки Аэртал
Назначаются внутрь по 100 мг (1 таблетка) 2 раза в сутки, с достаточным количеством воды.
Порошок для суспензии
Содержимое растворяют в 40-60 мл воды, принимают немедленно.
Взрослым показан 1 пакетик 2 раза в сутки. Детям Аэртал не рекомендуется давать из-за отсутствия данных о безопасности и эффективности применения в этом возрасте. Пожилым пациентам коррекция дозы не требуется.
При печеночной недостаточности рекомендованная начальная доза составляет 100 мг в сутки. При почечной недостаточности следует соблюдать осторожность. При необходимости лечение сокращается до минимально необходимого курса.
Крем (мазь)
Крем Аэртал применяется только наружно, окклюзионные повязки не рекомендуется.
Средства наносят легкими массирующими движениями 3 раза в сутки по 1-2 г в зависимости от зоны поражения. Детям средство не рекомендуется. Пожилым не требуется коррекция дозы.
Противопоказания
- эрозивно-язвенные поражения ЖКТ в фазе обострения;
- повышенная чувствительность к ацеклофенаку или другим компонентам препарата Аэртал, от чего таблетки, мазь и другие лекарственные формы могут вызывать побочные явления;
- детский и подростковый возраст до 18 лет;
- беременность;
- период лактации (грудное вскармливание);
- подтвержденная гиперкалиемия;
- выраженная почечная недостаточность, прогрессирующие заболевания почек;
- нарушения кроветворения и коагуляции;
- желудочно-кишечное кровотечение или подозрение на него;
- выраженная печеночная недостаточность или активное заболевание печени;
- период после проведения аорто-коронарного шунтирования;
- указания в анамнезе на бронхоспазм, крапивницу, ринит после приема ацетилсалициловой кислоты или других НПВС (полный или неполный синдром непереносимости ацетилсалициловой кислоты — риносинусит, крапивница, полипы слизистой оболочки носа, бронхиальная астма).
Почитайте также эту статью: Уколы, мазь и таблетки Ортофен: инструкция, цены и отзывы
Побочные действия
По инструкции Аэртал может вызывать такие негативные реакции организма:
- сыпь на коже;
- крапивница;
- анафилактический шок;
- отеки;
- тошнота;
- повышенное АД;
- рвота;
- отек Квинке;
- аритмия;
- язвенные поражения желудка;
- нарушение нормально работы сердечной мышцы;
- проблемы с почками;
- головная боль;
- снижение аппетита;
- проблемы со слухом и зрением;
- нарушения в работе печени;
- жидкий или твердый стул;
- излишняя возбудимость;
- тремор;
- эмоциональная неустойчивость;
- синдром Стивенса-Джонсона;
- шум в ушах.
Детям, при беременности и кормлении грудью
Препарат Аэртал при беременности и в период грудного вскармливания противопоказан к применению.
Клинические данные об его применении при беременности отсутствуют. Регулярное назначение нестероидных противовоспалительных средств (НПВС) в 3 триместре беременности может приводить к снижению тонуса и более слабым сокращениям матки.
Применение НПВС может приводить к преждевременному закрытию боталлова протока у плода и, возможно, к длительной легочной гипертензии у новорожденного, задержке начала родовой деятельности и увеличению продолжительности родов.
Данные о выделении ацеклофенака с грудным молоком у человека отсутствуют. В экспериментальных исследованиях при введении радиоактивного 14С-ацеклофенака лактирующим крысам заметного переноса радиоактивности в молоко не наблюдалось.
Запрещено давать Аэртал детям до 18-ти лет.
Особые указания
Больным с непереносимостью фруктозы нельзя назначать ацеклофенак в порошке, поскольку он содержит 2640 мг сорбитола, что может спровоцировать расстройство желудка или диарею.
Пациентам с фенилкетонурией важно учитывать, что в каждом пакетике порошка – 5,61 мг фенилаланина.
Необходимо проявлять осторожность пациентам с почечной, печеночной, сердечной недостаточностью, а также с другими заболеваниями, предполагающими развитие отеков. Прием НПВС у этой категории больных может привести к ухудшению почечной экскреции и возникновению отеков.
Лекарственное взаимодействие
Препарат может ингибировать изофермент CYP2С9 и по этой причине вступать во взаимодействие с фенитоином, циметидином, толбутамидом, фенилбутазоном, амиодароном, миконазолом и сульфафеназолом.
При сочетании с метотрексатом, циклоспорином, такролимусом и другими НПВП, а также ГКС, диуретиками, гипотензивными, гипогликемическими препаратами, зидовудином требуется коррекция дозы.
Аналоги лекарства Аэртал
К аналогам по структуре относят:
Для лечения ревматоидного артрита определяют аналоги по действию:
- Эндоксан.
- Клинорил.
- Верал.
- Наклофен.
- Иммард.
- Долгит.
- Преднизолон.
- Методжект.
- Дипроспан.
- Аулин.
- Мелоксам.
- Мирлокс.
- Доналгин.
- Диклоран.
- Ревмадор.
- Хайрумат.
- Диклоран плюс.
- Флолид.
- Мелоксикам.
- Мабтера.
- Тилкотил.
- Кетонал.
- Артротек.
- Аркоксиа.
- Дексалгин.
- Брустан.
- Лемод.
- Оргаспорин.
- Плаквенил.
- Нимулид.
- Ксефокам.
- Индометацин.
- Раптен Дуо.
- Напроксен.
- Эветрекс.
- Новолид.
- Немулекс.
- Дикловит.
- Мовикс.
- Актемра.
- Арава.
- Экорал.
- Вольтарен.
- Найз.
- Ибуклин.
- Диклофенак.
- Целебрекс.
- Вобэнзим.
- Тауредон.
- Нейродикловит.
- Артрофоон.
- Дексаметазон Никомед.
- Фламакс.
- Флексен.
- Азатиоприн.
- Мовасин.
- Дексазон.
- Полиоксидоний.
- Фастум гель.
- Актасулид.
- Имунофан.
- Мовалис.
- Налгезин.
- Коксиб.
- Кетопрофен.
- Мидокалм.
- Консупрен.
- Декортин.
- Циклоспорин.
- Месулид.
- Деринат.
- Полькортолон.
- Хумира.
- Би-ксикам.
- Амелотекс.
- Финалгель.
- Артрозилен.
- Ибупрофен.
Условия отпуска и цена
Средняя цена АЭРТАЛ (таблетки № 20) в Москве составляет 270 рублей. В Киеве купить лекарство можно за 108 гривен, в Казахстане — за 2210 тенге. В Минске аптеки предлагают таблетки за 10-12 бел. рублей. Отпускается из аптек по рецепту.
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